Immunology

Introduction of Immunology

Immunology, a field of biology and medicine, explores the intricate workings of immune systems across different organisms. Its relevance spans various medical disciplines, including organ transplantation, oncology, and rheumatology. The immune system safeguards the body against foreign invaders and aberrant self-cells, playing a vital role in maintaining human health. However, dysregulated immune responses can lead to tissue damage, altered organ growth, and functional impairments. Immunological disorders encompass chronic inflammation, autoimmune diseases, hypersensitivity reactions, immune deficiencies, and transplant rejection. Bispecific antibodies (BsAbs) offer potential in immunology by modulating receptor signaling pathways.

BsAbs in Immunology

Signaling networks orchestrate diverse biological functions, impacting cellular metabolism, proliferation, and overall health. BsAbs offer advantages over monospecific drugs by simultaneously targeting two receptors or ligands, reducing escape mechanisms and enhancing efficacy. Inflammatory and autoimmune diseases stem from dysregulated signaling. BsAbs designed to block pro-inflammatory pathways show promise in clinical trials. In addition, in cancer immunotherapy, BsAbs targeting CD19 and CD47 are advancing in research. The approval of BsAbs for acute lymphoblastic leukemia heralds progress in targeting novel cancer immunotherapy pathways. This underscores the potential of BsAbs in modulating intricate signaling networks for therapeutic benefit.

Creative Biolabs provides a wide range of more than 100 BsAb options to support research in immunology therapy. Customization services are available to meet specific research needs for immunology conditions. We are prepared to aid your scientific and medical research endeavors.

Fig. 1 Mechanisms and potential targets of BsAb in cancer.¹

Reference

1. Yang, Yan, Zheng Yang, and Yun Yang. "Potential role of CD47-directed bispecific antibodies in cancer immunotherapy." Frontiers in Immunology 12 (2021): 686031.