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4-1BB Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KLN-1125-LN26 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CD38 Trispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN25 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CD38 Trispecific Antibody (IgG-scFv) Human IgG-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN24 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CD38 Trispecific Antibody (Single-chain triplebody) Human Single-chain triplebody; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN23 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-MUC17 Trispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN22 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-MUC17 Trispecific Antibody (IgG-scFv) Human IgG-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN21 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-MUC17 Trispecific Antibody (Single-chain triplebody) Human Single-chain triplebody; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN20 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-DLL3 Trispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN19 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-DLL3 Trispecific Antibody (IgG-scFv) Human IgG-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN18 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-DLL3 Trispecific Antibody (Single-chain triplebody) Human Single-chain triplebody; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN17 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CD19 Trispecific Antibody (IgG-scFv) Human IgG-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN16 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CD19 Trispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN15 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CD19 Trispecific Antibody (Single-chain triplebody) Human Single-chain triplebody; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN14 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CEA Trispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN12 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-CEA Trispecific Antibody (Single-chain triplebody) Human Single-chain triplebody; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN11 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-HER2 Trispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN10 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-HER2 Trispecific Antibody (IgG-scFv) Human IgG-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN9 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-HER2 Trispecific Antibody (Single-chain triplebody) Human Single-chain triplebody; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN8 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-PSMA Trispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KLN-1125-LN7 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-EPCAM Trispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KN-1025-N11 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-PSMA Trispecific Antibody (IgG-scFv) Human IgG-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KN-1025-N10 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-EPCAM Trispecific Antibody (IgG-scFv) Human IgG-scFv; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KN-1025-N9 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-PSMA Trispecific Antibody (Single-chain triplebody) Human Single-chain triplebody; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KN-1025-N8 Recombinant Human Anti-CD3 x Anti-4-1BB x Anti-EPCAM Trispecific Antibody (Single-chain triplebody) Human Single-chain triplebody; Trispecific antibody CD3 Human 4-1BB Human Inquiry
KN-0825-N45 Recombinant Human Anti-GPC3 x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc GPC3 Human 4-1BB Human Inquiry
KN-0825-N44 Recombinant Human Anti-HER2 x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc HER2 Human 4-1BB Human Inquiry
KN-0825-N43 Recombinant Human Anti-CEA x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CEA Human 4-1BB Human Inquiry
KN-0825-N42 Recombinant Human Anti-EPCAM x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc EPCAM Human 4-1BB Human Inquiry
KN-0825-N41 Recombinant Human Anti-MSLN x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc MSLN Human 4-1BB Human Inquiry
KN-0825-N40 Recombinant Human Anti-CLDN18.2 x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CLDN18.2 Human 4-1BB Human Inquiry
KN-0825-N39 Recombinant Human Anti-B7H3 x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc B7H3 Human 4-1BB Human Inquiry
KN-0825-N38 Recombinant Human Anti-PD-L1 x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc PD-L1 Human 4-1BB Human Inquiry
KN-0825-N16 Recombinant Human Anti-GPC3 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv GPC3 Human 4-1BB Human Inquiry
KN-0825-N15 Recombinant Human Anti-HER2 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv HER2 Human 4-1BB Human Inquiry
KN-0825-N14 Recombinant Human Anti-CEA x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv CEA Human 4-1BB Human Inquiry
KN-0825-N13 Recombinant Human Anti-EPCAM x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv EPCAM Human 4-1BB Human Inquiry
KN-0825-N12 Recombinant Human Anti-MSLN x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv MSLN Human 4-1BB Human Inquiry
KN-0825-N11 Recombinant Human Anti-CLDN18.2 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv CLDN18.2 Human 4-1BB Human Inquiry
KN-0825-N10 Recombinant Human Anti-B7H3 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv B7H3 Human 4-1BB Human Inquiry
KN-0825-N9 Recombinant Human Anti-PD-L1 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv PD-L1 Human 4-1BB Human Inquiry
KN-0825-JL8 Anti-PSMA x Anti-4-1BB Bispecific aptamer (RNA/RNA) Human Bispecific Aptamer PSMA 4-1BB Inquiry
KN-0825-JL6 Anti-OPN x Anti-4-1BB Bispecific aptamer (RNA/RNA) Human Bispecific Aptamer OPN 4-1BB Inquiry
KN-0825-JL5 Anti-VEGF x Anti-4-1BB Bispecific aptamer (RNA/RNA) Human Bispecific Aptamer VEGF 4-1BB Inquiry

Background

4-1BB (also known as CD137 or TNFRSF9) is a type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily (TNFRSF). It consists of 255 amino acids with a molecular weight of ~28 kDa, featuring an extracellular domain containing four cysteine-rich motifs, a transmembrane helix, and an intracellular domain critical for downstream signaling. Primarily expressed on activated T cells and natural killer (NK) cells, 4-1BB is upregulated upon T-cell receptor engagement and interacts with its ligand 4-1BBL, which is predominantly displayed on antigen-presenting cells (APCs) like dendritic cells and macrophages. This receptor-ligand interaction recruits TRAF adaptor proteins (TRAF1, TRAF2, TRAF3) to form signalosomes, activating NF-κB and MAPK pathways that enhance T-cell proliferation, cytotoxic activity, and pro-inflammatory cytokine production, while suppressing apoptosis through upregulated anti-apoptotic proteins like Bcl-2. As a pivotal co-stimulatory molecule in adaptive immunity, 4-1BB has emerged as a promising target for cancer immunotherapy.
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