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Albumin & TNF Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem Diabody) Human Albumin TNF Inquiry
T-BSDB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem Diabody) Human Albumin TNF Inquiry
SCIGG-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scIgG) Human Single chain IgGs Albumin TNF Inquiry
FABVC-357 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-VHH-Fc) Human Fab-Fc Fusion Proteins Albumin TNF Inquiry
BSSG-357 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (VHH-IgG) Human Appended IgGs Albumin TNF Inquiry
HCAB-002 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (VHH-Fc-VHH) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
BIBD-357 Recombinant Anti-Albumin x Anti-TNF VHH BispecificAntibody (Bibody) Human Bibody Albumin TNF Inquiry
IGVHH-002 Recombinant Anti-Albumin x Anti-TNF VHH BispecificAntibody (IgG-VHH) Human Appended IgGs Albumin TNF Inquiry
BIVHH-002 Recombinant Anti-Albumin VHH x Anti-TNF VHH BispecificAntibody (Bi-sdAb) Human Bi-sdAb Albumin TNF Inquiry
SCIGG-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scIgG) Human Single chain IgGs Albumin TNF Inquiry
FVTIG-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scFv4-Ig) Human Appended IgGs Albumin TNF Inquiry
FVTIG-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scFv4-Ig) Human Appended IgGs Albumin TNF Inquiry
BSSG-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scFv-IgG) Human Appended IgGs Albumin TNF Inquiry
BSSG-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scFv-IgG) Human Appended IgGs Albumin TNF Inquiry
IGLFV-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs Albumin TNF Inquiry
IGLFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs Albumin TNF Inquiry
BSGV-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (IgG-Fv) Human IgG-Fv Albumin TNF Inquiry
BSGV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-Fv) Human IgG-Fv Albumin TNF Inquiry
BSDG-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Fv-IgG) Human Appended IgGs Albumin TNF Inquiry
BSDG-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fv-IgG) Human Appended IgGs Albumin TNF Inquiry
BABFV-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Albumin TNF Inquiry
BABFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Albumin TNF Inquiry
FABVC-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Albumin TNF Inquiry
FABVC-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Albumin TNF Inquiry
SCDBC-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
SCDBC-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
BSDBC-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
BSDBC-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
SCDBF-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
SCDBF-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
BSFVF-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
BSFVF-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
BSDBF-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
BSDBF-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Albumin TNF Inquiry
BSTF-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSTF-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSCFV-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSCFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
MNAB-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
MNAB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSFC-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSFC-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSCC-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BSCC-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments Albumin TNF Inquiry
BIBD-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody Albumin TNF Inquiry
BIBD-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Bibody) Human Bibody Albumin TNF Inquiry
FABFV-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv Albumin TNF Inquiry
FABFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv Albumin TNF Inquiry
MiniB-H195 Recombinant Human Anti-Albumin x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody Albumin TNF Inquiry
MiniB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Minibody) Human Minibody Albumin TNF Inquiry
SCDB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Albumin TNF Inquiry
FABIG-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG Albumin TNF Inquiry
TRIB-H195 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body Albumin TNF Inquiry
BSIG-H193 Human Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG Albumin TNF Inquiry
CROSSAB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab Albumin TNF Inquiry
IGFV-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv Albumin TNF Inquiry
BSDB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Diabody) Human Diabody Albumin TNF Inquiry
BSFAB-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab Albumin TNF Inquiry
BSFV-H193 Recombinant Human Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv Albumin TNF Inquiry
SCDB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Albumin TNF Inquiry
FABIG-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG Albumin TNF Inquiry
TRIB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body Albumin TNF Inquiry
BSIG-007 Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG Albumin TNF Inquiry
CROSSAB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab Albumin TNF Inquiry
IGFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv Albumin TNF Inquiry
BSDB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Diabody) Human Diabody Albumin TNF Inquiry
BSFAB-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab Albumin TNF Inquiry
BSFV-007 Recombinant Anti-Albumin x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv Albumin TNF Inquiry
BSCC-H194 Recombinant Human Anti-Albumin x Human Anti-IL-6R Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments Albumin IL-6R Inquiry
BSCC-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments NGF TNF Inquiry
BSCC-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments IL17 TNF Inquiry
BSCC-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments Albumin IL-6R Inquiry
BIBD-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody NGF TNF Inquiry
BIBD-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody IL17 TNF Inquiry
BIBD-H194 Recombinant Human Anti-Albumin x Human Anti-IL-6R Bispecific Antibody (Bibody) Human Bibody Albumin IL-6R Inquiry
BIBD-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Bibody) Human Bibody NGF TNF Inquiry
BIBD-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Bibody) Human Bibody IL17 TNF Inquiry
BIBD-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (Bibody) Human Bibody Albumin IL-6R Inquiry
FABFV-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv NGF TNF Inquiry
FABFV-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 TNF Inquiry
FABFV-H194 Recombinant Human Anti-Albumin x Human Anti-IL-6R Bispecific Antibody (Fab-Fv) Human Fab-Fv Albumin IL-6R Inquiry
FABFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv NGF TNF Inquiry
FABFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 TNF Inquiry
FABFV-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (Fab-Fv) Human Fab-Fv Albumin IL-6R Inquiry
MiniB-H346 Recombinant Human Anti-NGF x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody NGF TNF Inquiry
MiniB-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 TNF Inquiry
MiniB-H194 Recombinant Human Anti-Albumin x Human Anti-IL-6R Bispecific Antibody (Minibody) Human Minibody Albumin IL-6R Inquiry
MiniB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Minibody) Human Minibody NGF TNF Inquiry
MiniB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 TNF Inquiry
MiniB-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (Minibody) Human Minibody Albumin IL-6R Inquiry
SCDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody NGF TNF Inquiry
SCDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 TNF Inquiry
SCDB-H192 Recombinant Human Anti-Albumin x Anti-IL-6R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Albumin IL-6R Inquiry
FABIG-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG NGF TNF Inquiry
FABIG-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 TNF Inquiry
FABIG-H192 Recombinant Human Anti-Albumin x Anti-IL-6R Bispecific Antibody (Fab-IgG) Human Fab-IgG Albumin IL-6R Inquiry
TRIB-H346 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body NGF TNF Inquiry
TRIB-H341 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body IL17 TNF Inquiry
TRIB-H194 Recombinant Human Anti-Albumin x Anti-IL-6R Bispecific Antibody (Triple Body) Human Triple Body Albumin IL-6R Inquiry
BSIG-H344 Human Anti-NGF x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG NGF TNF Inquiry
BSIG-H339 Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 TNF Inquiry
BSIG-H192 Human Anti-Albumin x Anti-IL-6R Bispecific Antibody (IgG-IgG) Human IgG-IgG Albumin IL-6R Inquiry
CROSSAB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab NGF TNF Inquiry
CROSSAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 TNF Inquiry
CROSSAB-H192 Recombinant Human Anti-Albumin x Anti-IL-6R Bispecific Antibody (CrossMab) Human CrossMab Albumin IL-6R Inquiry
IGFV-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv NGF TNF Inquiry
IGFV-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 TNF Inquiry
IGFV-H192 Recombinant Human Anti-Albumin x Anti-IL-6R Bispecific Antibody (IgG-scFv) Human IgG-scFv Albumin IL-6R Inquiry
BSDB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Diabody) Human Diabody NGF TNF Inquiry
BSDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 TNF Inquiry
BSDB-H192 Recombinant Human Anti-Albumin x Anti-IL-6R Bispecific Antibody (Diabody) Human Diabody Albumin IL-6R Inquiry
BSFAB-H344 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab NGF TNF Inquiry
BSFAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 TNF Inquiry
BSFAB-H192 Recombinant Human Anti-Albumin x Anti-IL-6R Bispecific Antibody (Tandem Fab) Human Tandem Fab Albumin IL-6R Inquiry
BSFV-H343 Recombinant Human Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv NGF TNF Inquiry
BSFV-H337 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 TNF Inquiry
BSFV-H192 Recombinant Human Anti-Albumin x Anti-IL-6R Bispecific Antibody (Tandem scFv) Human Tandem scFv Albumin IL-6R Inquiry
SCDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody NGF TNF Inquiry
SCDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 TNF Inquiry
SCDB-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Albumin IL-6R Inquiry
FABIG-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG NGF TNF Inquiry
FABIG-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 TNF Inquiry
FABIG-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (Fab-IgG) Human Fab-IgG Albumin IL-6R Inquiry
TRIB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body NGF TNF Inquiry
TRIB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body IL17 TNF Inquiry
TRIB-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (Triple Body) Human Triple Body Albumin IL-6R Inquiry
BSIG-182 Anti-NGF x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG NGF TNF Inquiry
BSIG-175 Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 TNF Inquiry
BSIG-006 Anti-Albumin x Anti-IL-6R Bispecific Antibody (IgG-IgG) Human IgG-IgG Albumin IL-6R Inquiry
CROSSAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 TNF Inquiry
CROSSAB-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (CrossMab) Human CrossMab Albumin IL-6R Inquiry
IGFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv NGF TNF Inquiry
IGFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 TNF Inquiry
IGFV-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (IgG-scFv) Human IgG-scFv Albumin IL-6R Inquiry
BSDB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Diabody) Human Diabody NGF TNF Inquiry
BSDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 TNF Inquiry
BSDB-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (Diabody) Human Diabody Albumin IL-6R Inquiry
BSFAB-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab NGF TNF Inquiry
BSFAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 TNF Inquiry
BSFAB-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (Tandem Fab) Human Tandem Fab Albumin IL-6R Inquiry
BSFV-182 Recombinant Anti-NGF x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv NGF TNF Inquiry
BSFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 TNF Inquiry
BSFV-006 Recombinant Anti-Albumin x Anti-IL-6R Bispecific Antibody (Tandem scFv) Human Tandem scFv Albumin IL-6R Inquiry

Background

Albumin is a protein produced by the liver that serves as a carrier molecule for various substances in the blood. TNF (tumor necrosis factor) is a cytokine produced by immune cells that is involved in inflammation and immune response regulation. The anti-albumin×anti-TNF bispecific antibody (BsAb) binding to both albumin and TNF simultaneously facilitates the specific delivery of TNF inhibitors to sites of inflammation, where they can block the actions of TNF. By neutralizing TNF, which can contribute to chronic inflammation in conditions such as rheumatoid arthritis and inflammatory bowel disease, this BsAb helps reduce inflammation and alleviate symptoms associated with these diseases. This BsAb could potentially be utilized to treat inflammatory and autoimmune diseases. In addition, this BsAb may have potential applications in cancer immunotherapy, as TNF can enhance immune responses against tumors.

Fig.1 Human serum albumin and TNF with its inhibitor. (Larsen, et al., 2016; Guven-Maiorov, et al., 2014) Fig.1 Structures of human serum albumin and TNF with its inhibitor.1,2

References

  1. Larsen, Maja Thim, et al. "Albumin-based drug delivery: harnessing nature to cure disease." Molecular and cellular therapies 4.1 (2016): 1-12.
  2. Guven-Maiorov, Emine, et al. "Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy." Cancers 6.2 (2014): 663-683.
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