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B Cell Lymphoma BCL1 Idiotype & CD64 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Tandem Diabody) Mouse B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
SCIGG-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (scIgG) Mouse Single chain IgGs B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
FVTIG-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (scFv4-Ig) Mouse Appended IgGs B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSSG-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (scFv-IgG) Mouse Appended IgGs B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
IGLFV-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (IgG(L)-scFv) Mouse Appended IgGs B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSGV-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (IgG-Fv) Mouse IgG-Fv B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSDG-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Fv-IgG) Mouse Appended IgGs B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BABFV-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (F(ab')2-scFv2) Mouse Fab-Fc Fusion Proteins B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
FABVC-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Fab-scFv-Fc) Mouse Fab-Fc Fusion Proteins B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
SCDBC-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (scDiabody-CH3) Mouse Constant Domain-extended Bispecific Fragments B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSDBC-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Diabody-CH3) Mouse Constant Domain-extended Bispecific Fragments B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
SCDBF-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (scDiabody-Fc) Mouse Constant Domain-extended Bispecific Fragments B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSFVF-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Tandem scFv-Fc) Mouse Constant Domain-extended Bispecific Fragments B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSDBF-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Diabody-Fc) Mouse Constant Domain-extended Bispecific Fragments B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSTF-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (scFv-Fc-scFv) Mouse scFv-Fc-scFv B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSCFV-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (scFv-Fc) Mouse scFv-Fc B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
MNAB-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Miniantibody) Mouse Miniantibody B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSFC-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (scFv-CH3) Mouse scFv-based Bispecific Fragments B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSCC-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (scFv-CH1/CL) Mouse scFv-CH1/CL B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BIBD-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Bibody) Mouse Bibody B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
FABFV-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Fab-Fv) Mouse Fab-Fv B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
MiniB-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Minibody) Mouse Minibody B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
SCTB-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Single-chain Triplebody) Mouse Single-chain Triplebody B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
SCDB-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Single-chain Diabody) Mouse Single-chain Diabody B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
FABIG-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Fab-IgG) Mouse Fab-IgG B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
TRIB-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Triple Body) Mouse Triple Body B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSIG-001 Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (IgG-IgG) Mouse IgG-IgG B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
CROSSAB-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (CrossMab) Mouse CrossMab B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
IGFV-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (IgG-scFv) Mouse IgG-scFv B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSDB-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Diabody) Mouse Diabody B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSFAB-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Tandem Fab) Mouse Tandem Fab B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
BSFV-001 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD64 Bispecific Antibody (Tandem scFv) Mouse Tandem scFv B Cell Lymphoma BCL1 Idiotype CD64 Inquiry
FABIG-016 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD3 Bispecific Antibody (Fab-IgG) Mouse Fab-IgG B Cell Lymphoma BCL1 Idiotype CD3 Inquiry
TRIB-147 Recombinant Anti-DENV x Anti-CD64 Bispecific Antibody (Triple Body) Human Triple Body DENV CD64 Inquiry
TRIB-129 Recombinant Anti-CD64 x Anti-Malaria Antigen Bispecific Antibody (Triple Body) Human Triple Body CD64 Malaria Antigen Inquiry
TRIB-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (Triple Body) Human Triple Body CD64 HER2 Inquiry
TRIB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Triple Body) Human Triple Body CD64 HIV-1 gp41 Inquiry
TRIB-126 Recombinant Anti-CD64 x Anti-GD2 Bispecific Antibody (Triple Body) Human Triple Body CD64 GD2 Inquiry
TRIB-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (Triple Body) Human Triple Body CD64 EGFR Inquiry
TRIB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Triple Body) Human Triple Body CD37 CD64 Inquiry
TRIB-115 Recombinant Anti-CD33 x Anti-CD64 Bispecific Antibody (Triple Body) Human Triple Body CD33 CD64 Inquiry
TRIB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Triple Body) Human Triple Body CD30 CD64 Inquiry
TRIB-044 Recombinant Anti-CD19 x Anti-CD64 Bispecific Antibody (Triple Body) Human Triple Body CD19 CD64 Inquiry
TRIB-032 Recombinant Anti-CD15 x Anti-CD64 Bispecific Antibody (Triple Body) Human Triple Body CD15 CD64 Inquiry
TRIB-023 Recombinant Anti-C. albicans x Anti-CD64 Bispecific Antibody (Triple Body) Human Triple Body C. albicans CD64 Inquiry
TRIB-016 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD3 Bispecific Antibody (Triple Body) Mouse Triple Body B Cell Lymphoma BCL1 Idiotype CD3 Inquiry
BSIG-147 Anti-DENV x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG DENV CD64 Inquiry
BSIG-129 Anti-CD64 x Anti-Malaria Antigen Bispecific Antibody (IgG-IgG) Human IgG-IgG CD64 Malaria Antigen Inquiry
BSIG-128 Anti-CD64 x Anti-HER2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD64 HER2 Inquiry
BSIG-127 Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD64 HIV-1 gp41 Inquiry
BSIG-126 Anti-CD64 x Anti-GD2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD64 GD2 Inquiry
BSIG-125 Anti-CD64 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD64 EGFR Inquiry
BSIG-117 Anti-CD37 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD37 CD64 Inquiry
BSIG-115 Anti-CD33 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD33 CD64 Inquiry
BSIG-110 Anti-CD30 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD30 CD64 Inquiry
BSIG-044 Anti-CD19 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 CD64 Inquiry
BSIG-032 Anti-CD15 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD15 CD64 Inquiry
BSIG-023 Anti-C. albicans x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG C. albicans CD64 Inquiry
BSIG-016 Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD3 Bispecific Antibody (IgG-IgG) Mouse IgG-IgG B Cell Lymphoma BCL1 Idiotype CD3 Inquiry
CROSSAB-147 Recombinant Anti-DENV x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab DENV CD64 Inquiry
CROSSAB-129 Recombinant Anti-CD64 x Anti-Malaria Antigen Bispecific Antibody (CrossMab) Human CrossMab CD64 Malaria Antigen Inquiry
CROSSAB-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (CrossMab) Human CrossMab CD64 HER2 Inquiry
CROSSAB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (CrossMab) Human CrossMab CD64 HIV-1 gp41 Inquiry
CROSSAB-126 Recombinant Anti-CD64 x Anti-GD2 Bispecific Antibody (CrossMab) Human CrossMab CD64 GD2 Inquiry
CROSSAB-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD64 EGFR Inquiry
CROSSAB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD37 CD64 Inquiry
CROSSAB-115 Recombinant Anti-CD33 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD33 CD64 Inquiry
CROSSAB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD30 CD64 Inquiry
CROSSAB-044 Recombinant Anti-CD19 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD19 CD64 Inquiry
CROSSAB-032 Recombinant Anti-CD15 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD15 CD64 Inquiry
CROSSAB-023 Recombinant Anti-C. albicans x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab C. albicans CD64 Inquiry
CROSSAB-016 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD3 Bispecific Antibody (CrossMab) Mouse CrossMab B Cell Lymphoma BCL1 Idiotype CD3 Inquiry
IGFV-147 Recombinant Anti-DENV x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv DENV CD64 Inquiry
IGFV-129 Recombinant Anti-CD64 x Anti-Malaria Antigen Bispecific Antibody (IgG-scFv) Human IgG-scFv CD64 Malaria Antigen Inquiry
IGFV-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD64 HER2 Inquiry
IGFV-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD64 HIV-1 gp41 Inquiry
IGFV-126 Recombinant Anti-CD64 x Anti-GD2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD64 GD2 Inquiry
IGFV-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD64 EGFR Inquiry
IGFV-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD37 CD64 Inquiry
IGFV-115 Recombinant Anti-CD33 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD33 CD64 Inquiry
IGFV-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD30 CD64 Inquiry
IGFV-044 Recombinant Anti-CD19 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 CD64 Inquiry
IGFV-032 Recombinant Anti-CD15 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD15 CD64 Inquiry
IGFV-023 Recombinant Anti-C. albicans x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv C. albicans CD64 Inquiry
IGFV-016 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD3 Bispecific Antibody (IgG-scFv) Mouse IgG-scFv B Cell Lymphoma BCL1 Idiotype CD3 Inquiry
BSDB-147 Recombinant Anti-DENV x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody DENV CD64 Inquiry
BSDB-129 Recombinant Anti-CD64 x Anti-Malaria Antigen Bispecific Antibody (Diabody) Human Diabody CD64 Malaria Antigen Inquiry
BSDB-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CD64 HER2 Inquiry
BSDB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody) Human Diabody CD64 HIV-1 gp41 Inquiry
BSDB-126 Recombinant Anti-CD64 x Anti-GD2 Bispecific Antibody (Diabody) Human Diabody CD64 GD2 Inquiry
BSDB-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD64 EGFR Inquiry
BSDB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD37 CD64 Inquiry
BSDB-115 Recombinant Anti-CD33 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD33 CD64 Inquiry
BSDB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD30 CD64 Inquiry
BSDB-044 Recombinant Anti-CD19 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD19 CD64 Inquiry
BSDB-032 Recombinant Anti-CD15 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD15 CD64 Inquiry
BSDB-023 Recombinant Anti-C. albicans x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody C. albicans CD64 Inquiry
BSDB-016 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD3 Bispecific Antibody (Diabody) Mouse Diabody B Cell Lymphoma BCL1 Idiotype CD3 Inquiry
BSFAB-147 Recombinant Anti-DENV x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab DENV CD64 Inquiry
BSFAB-129 Recombinant Anti-CD64 x Anti-Malaria Antigen Bispecific Antibody (Tandem Fab) Human Tandem Fab CD64 Malaria Antigen Inquiry
BSFAB-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD64 HER2 Inquiry
BSFAB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD64 HIV-1 gp41 Inquiry
BSFAB-126 Recombinant Anti-CD64 x Anti-GD2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD64 GD2 Inquiry
BSFAB-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD64 EGFR Inquiry
BSFAB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD37 CD64 Inquiry
BSFAB-115 Recombinant Anti-CD33 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD33 CD64 Inquiry
BSFAB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD30 CD64 Inquiry
BSFAB-044 Recombinant Anti-CD19 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 CD64 Inquiry
BSFAB-032 Recombinant Anti-CD15 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD15 CD64 Inquiry
BSFAB-023 Recombinant Anti-C. albicans x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab C. albicans CD64 Inquiry
BSFAB-016 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD3 Bispecific Antibody (Tandem Fab) Mouse Tandem Fab B Cell Lymphoma BCL1 Idiotype CD3 Inquiry
BSFV-147 Recombinant Anti-DENV x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv DENV CD64 Inquiry
BSFV-129 Recombinant Anti-CD64 x Anti-Malaria Antigen Bispecific Antibody (Tandem scFv) Human Tandem scFv CD64 Malaria Antigen Inquiry
BSFV-128 Recombinant Anti-CD64 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD64 HER2 Inquiry
BSFV-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD64 HIV-1 gp41 Inquiry
BSFV-126 Recombinant Anti-CD64 x Anti-GD2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD64 GD2 Inquiry
BSFV-125 Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD64 EGFR Inquiry
BSFV-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD37 CD64 Inquiry
BSFV-115 Recombinant Anti-CD33 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD33 CD64 Inquiry
BSFV-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD30 CD64 Inquiry
BSFV-044 Recombinant Anti-CD19 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 CD64 Inquiry
BSFV-032 Recombinant Anti-CD15 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD15 CD64 Inquiry
BSFV-023 Recombinant Anti-C. albicans x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv C. albicans CD64 Inquiry
BSFV-016 Recombinant Anti-B Cell Lymphoma BCL1 Idiotype x Anti-CD3 Bispecific Antibody (Tandem scFv) Mouse Tandem scFv B Cell Lymphoma BCL1 Idiotype CD3 Inquiry

Background

B cell lymphoma BCL1 Idiotype refers to a specific marker found on the surface of cancerous B cells in B cell lymphoma. It is an antigenic protein that is specific to cancer cells and can be exploited as a therapeutic target. CD64, also known as FcγRI, is a receptor located on the surface of immune cells like monocytes and macrophages. The anti-B cell lymphoma BCL1 Idiotype×anti-CD64 bispecific antibody (BsAb) can be constructed to facilitate the engagement of immune cells to the cancer cells, leading to enhanced immune responses against the tumor and triggering antibody-dependent cellular cytotoxicity and phagocytosis, ultimately destroying cancer cells. The application fields of this BsAb include the treatment of B cell lymphomas expressing the BCL1 Idiotype. By harnessing the immune system's power, this therapy aims to specifically target and eliminate cancer cells, potentially improving patient outcomes.

Fig.1 Mechanisms of action of BCL1 and CD64. (Martelli, et al., 2005; Chenoweth, et al., 2015) Fig.1 Functions of BCL1 and CD64.1,2

References

  1. Martelli, Maurizio, et al. "Nodal aggressive non-Hodgkin’s lymphoma in the adult: a review article." Hematology Meeting Reports (formerly Haematologica Reports). Vol. 1. No. 12. 2005.
  2. Chenoweth, Alicia M., et al. "The high‐affinity receptor for IgG, FcγRI, of humans and non‐human primates." Immunological Reviews 268.1 (2015): 175-191.
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