B7H6 (B7-H6, B7 homolog 6 or DKFZp686O24166) is also named for the gene in humans, natural killer cell cytotoxicity receptor 3 ligand 1 (NCR3LG1). This is a type I transmembrane protein with a mass of 50.8 kDa. B7H6 is a member of the B7 family and encodes the protein of 454 amino acids length. The gene of B7H6 shares homology with other species, such as rat, with considerable analogy with B7H1 and B7H3 protein. It has been identified as a specific ligand for the NKp30, the natural killer cell-activating receptor. That Interaction between B7H6 and NKp30 will result in the activation and cytotoxicity of natural killer cell and trigger innate immunity for cellular transformation. B7H6 expression is not detected in normal tissues of humans, but is found to be selectively expressed on tumor cells (e.g. leukemia, lymphoma, and gastrointestinal stromal tumors). CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes.