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CCR5 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H204 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CCR5 Human CD3 Human Inquiry
T-BSDB-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CCR5 Mouse CD3 Mouse Inquiry
SCIGG-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (scIgG) Human Single chain IgGs CCR5 Human CD3 Human Inquiry
FABVC-359 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc CCR5 Mouse CD3 llama Inquiry
BSSG-359 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (sdAb-IgG) Human sdAb-IgG CCR5 Mouse CD3 llama Inquiry
HCAB-004 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb CCR5 llama CD3 llama Inquiry
BIBD-359 Recombinant Anti-CCR5 x Anti-CD3 VHH BispecificAntibody (Bibody) Human Bibody CCR5 Mouse CD3 llama Inquiry
IGVHH-004 Recombinant Anti-CCR5 x Anti-CD3 sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb CCR5 Mouse CD3 llama Inquiry
BIVHH-003 Recombinant Anti-CCR5 sdAb x Anti-CD3 sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb CCR5 llama CD3 llama Inquiry
SCIGG-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scIgG) Human Single chain IgGs CCR5 Mouse CD3 Mouse Inquiry
FVTIG-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CCR5 Human CD3 Human Inquiry
FVTIG-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CCR5 Mouse CD3 Mouse Inquiry
BSSG-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CCR5 Human CD3 Human Inquiry
BSSG-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CCR5 Mouse CD3 Mouse Inquiry
IGLFV-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CCR5 Human CD3 Human Inquiry
IGLFV-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CCR5 Mouse CD3 Mouse Inquiry
BSGV-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CCR5 Mouse CD3 Mouse Inquiry
BSGV-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CCR5 Mouse CD3 Mouse Inquiry
BSDG-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CCR5 Human CD3 Human Inquiry
BSDG-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CCR5 Mouse CD3 Mouse Inquiry
BABFV-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CCR5 Human CD3 Human Inquiry
BABFV-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CCR5 Mouse CD3 Mouse Inquiry
FABVC-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CCR5 Human CD3 Human Inquiry
FABVC-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CCR5 Mouse CD3 Mouse Inquiry
SCDBC-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CCR5 Human CD3 Human Inquiry
SCDBC-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CCR5 Mouse CD3 Mouse Inquiry
BSDBC-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CCR5 Human CD3 Human Inquiry
BSDBC-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CCR5 Mouse CD3 Mouse Inquiry
SCDBF-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CCR5 Human CD3 Human Inquiry
SCDBF-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CCR5 Mouse CD3 Mouse Inquiry
BSFVF-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CCR5 Human CD3 Human Inquiry
BSFVF-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CCR5 Mouse CD3 Mouse Inquiry
BSDBF-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CCR5 Human CD3 Human Inquiry
BSDBF-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CCR5 Mouse CD3 Mouse Inquiry
BSTF-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CCR5 Mouse CD3 Mouse Inquiry
BSTF-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CCR5 Mouse CD3 Mouse Inquiry
BSCFV-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CCR5 Mouse CD3 Mouse Inquiry
BSCFV-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CCR5 Mouse CD3 Mouse Inquiry
MNAB-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (Miniantibody) Human Miniantibody CCR5 Mouse CD3 Mouse Inquiry
MNAB-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Miniantibody) Human Miniantibody CCR5 Mouse CD3 Mouse Inquiry
BSFC-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CCR5 Mouse CD3 Mouse Inquiry
BSFC-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CCR5 Mouse CD3 Mouse Inquiry
BSCC-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CCR5 Mouse CD3 Mouse Inquiry
BSCC-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CCR5 Mouse CD3 Mouse Inquiry
BIBD-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (Bibody) Human Bibody CCR5 Mouse CD3 Mouse Inquiry
BIBD-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Bibody) Human Bibody CCR5 Mouse CD3 Mouse Inquiry
FABFV-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CCR5 Human CD3 Human Inquiry
FABFV-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CCR5 Mouse CD3 Mouse Inquiry
MiniB-H206 Recombinant Human Anti-CCR5 x Human Anti-CD3 Bispecific Antibody (Minibody) Human Minibody CCR5 Human CD3 Human Inquiry
MiniB-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Minibody) Human Minibody CCR5 Mouse CD3 Mouse Inquiry
SCTB-H108 Recombinant Human Anti-CCR5 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CCR5 Human CD3 Human Inquiry
SCDB-H204 Recombinant Human Anti-CCR5 x Anti-CD3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CCR5 Human CD3 Human Inquiry
FABIG-H204 Recombinant Human Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CCR5 Human CD3 Human Inquiry
TRIB-H206 Recombinant Human Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CCR5 Human CD3 Human Inquiry
BSIG-H204 Human Anti-CCR5 x Anti-CD3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CCR5 Human CD3 Human Inquiry
CROSSAB-H204 Recombinant Human Anti-CCR5 x Anti-CD3 Bispecific Antibody (CrossMab) Human CrossMab CCR5 Human CD3 Human Inquiry
IGFV-H204 Recombinant Human Anti-CCR5 x Anti-CD3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CCR5 Human CD3 Human Inquiry
BSDB-H204 Recombinant Human Anti-CCR5 x Anti-CD3 Bispecific Antibody (Diabody) Human Diabody CCR5 Human CD3 Human Inquiry
BSFAB-H204 Recombinant Human Anti-CCR5 x Anti-CD3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CCR5 Human CD3 Human Inquiry
BSFV-H204 Recombinant Human Anti-CCR5 x Anti-CD3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CCR5 Human CD3 Human Inquiry
SCTB-008 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CCR5 Mouse CD3 Mouse Inquiry
SCDB-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CCR5 Mouse CD3 Mouse Inquiry
FABIG-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CCR5 Mouse CD3 Mouse Inquiry
TRIB-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CCR5 Mouse CD3 Mouse Inquiry
BSIG-029 Anti-CCR5 x Anti-CD3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CCR5 Mouse CD3 Mouse Inquiry
CROSSAB-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (CrossMab) Human CrossMab CCR5 Mouse CD3 Mouse Inquiry
IGFV-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CCR5 Mouse CD3 Mouse Inquiry
BSDB-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Diabody) Human Diabody CCR5 Mouse CD3 Mouse Inquiry
BSFAB-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CCR5 Mouse CD3 Mouse Inquiry
BSFV-029 Recombinant Anti-CCR5 x Anti-CD3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CCR5 Mouse CD3 Mouse Inquiry

Background

CCR5 is a versatile receptor of a molecular weight of 40.6 kDa, incorporating a total of 352 amino acid residues. It majorly finds its expression on the cellular membranes of monocytes, immature dendritic cells, and resting T-lymphocytes.

Functioning as a receptor for intracellular β-chemokines, CCR5 modulates the migration, proliferation, and immunological processes of T cells, monocytes, and the macrophage lineage. Its primary downstream pathways encompass:

  • The CCL5/CCR5 mediated phosphorylation of Thr1462 on TSC-2 by PI3K/AKT, thus obstructing the formation of the TSC-1/TSC-2 complex.
  • The activation of AKT and GSK-3b in the PI3K/AKT pathway by the CCL5/CCR5 axis, subsequently modulating its downstream derivatives.
  • The activation of Hypoxia-Inducible Factor α (HIF-α) pathway via CCL5/CCR5 by amplifying the stability and accumulation of HIF1a.

In addition, CCR5 is also reputed as a primary co-receptor for HIV. It promotes involvement in the proliferation and development of hematological malignancies and several solid tumors through its interaction with the hematopoietic stem cell marker CD34.

CCL5 and CCR5 pathway. (Zeng, et al., 2022) Fig.1 CCL5 and CCR5 pathway.1

Reference

  1. Zeng, Lan, et al. "CCL5/CCR5 axis in human diseases and related treatments." Genes and Diseases. 9 (2022): 12-27.
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