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CD22 & Saporin Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD22 Mouse saporin Mouse Inquiry
SCIGG-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (scIgG) Human Single chain IgGs CD22 Mouse Saporin Mouse Inquiry
FVTIG-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD22 Mouse saporin Mouse Inquiry
BSSG-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (scFv-IgG) Human scFv-IgG CD22 Mouse saporin Mouse Inquiry
IGLFV-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD22 Mouse saporin Mouse Inquiry
BSGV-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (IgG-Fv) Human IgG-Fv CD22 Mouse saporin Mouse Inquiry
BSDG-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (Fv-IgG) Human Fv-IgG CD22 Mouse saporin Mouse Inquiry
BABFV-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD22 Mouse saporin Mouse Inquiry
FABVC-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD22 Mouse saporin Mouse Inquiry
SCDBC-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD22 Mouse saporin Mouse Inquiry
BSDBC-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD22 Mouse saporin Mouse Inquiry
SCDBF-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD22 Mouse saporin Mouse Inquiry
BSFVF-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD22 Mouse saporin Mouse Inquiry
BSDBF-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD22 Mouse saporin Mouse Inquiry
BSTF-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD22 Mouse saporin Mouse Inquiry
BSCFV-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (scFv-Fc) Human scFv-Fc CD22 Mouse saporin Mouse Inquiry
MNAB-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (Miniantibody) Human Miniantibody CD22 Mouse saporin Mouse Inquiry
BSFC-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD22 Mouse saporin Mouse Inquiry
BSCC-053 Recombinant Anti-CD22 x Anti-saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD22 Mouse saporin Mouse Inquiry
BIBD-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD22 Mouse Saporin Mouse Inquiry
FABFV-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD22 Mouse Saporin Mouse Inquiry
MiniB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD22 Mouse Saporin Mouse Inquiry
SCDB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD22 Mouse Saporin Mouse Inquiry
FABIG-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD22 Mouse Saporin Mouse Inquiry
TRIB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD22 Mouse Saporin Mouse Inquiry
BSIG-053 Anti-CD22 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD22 Mouse Saporin Mouse Inquiry
CROSSAB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD22 Mouse Saporin Mouse Inquiry
IGFV-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD22 Mouse Saporin Mouse Inquiry
BSDB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD22 Mouse Saporin Mouse Inquiry
BSFAB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD22 Mouse Saporin Mouse Inquiry
BSFV-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD22 Mouse Saporin Mouse Inquiry
BSFAB-PE004 Recombinant Anti-CD20 x Anti-CD22 Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Mouse CD22 Mouse Inquiry
BSFAB-PE003 Recombinant Anti-CD19 x Anti-CD22 Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Mouse CD22 Mouse Inquiry
BSFAB-DT022 Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Human CD22 Human Inquiry
BSFAB-DT021 Recombinant Human Anti-CD19 x Human Anti-CD22 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Human CD22 Human Inquiry
BSFAB-DT004 Recombinant Anti-CD20 x Anti-CD22 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Mouse CD22 Mouse Inquiry
BSFAB-DT003 Recombinant Anti-CD19 x Anti-CD22 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Mouse CD22 Mouse Inquiry
BSFV-SAR022 Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Human CD22 Human Inquiry
BSFV-SAR021 Recombinant Human Anti-CD19 x Human Anti-CD22 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Human CD22 Human Inquiry
BSFV-SAR004 Recombinant Anti-CD20 x Anti-CD22 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Mouse CD22 Mouse Inquiry
BSFV-SAR003 Recombinant Anti-CD19 x Anti-CD22 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Mouse CD22 Mouse Inquiry
BSFV-NGB022 Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Human CD22 Human Inquiry
BSFV-NGB021 Recombinant Human Anti-CD19 x Human Anti-CD22 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Human CD22 Human Inquiry
BSFV-NGB004 Recombinant Anti-CD20 x Anti-CD22 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Mouse CD22 Mouse Inquiry
BSFV-NGB003 Recombinant Anti-CD19 x Anti-CD22 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Mouse CD22 Mouse Inquiry
BSFV-MEL022 Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Human CD22 Human Inquiry
BSFV-MEL021 Recombinant Human Anti-CD19 x Human Anti-CD22 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Human CD22 Human Inquiry
BSFV-MEL004 Recombinant Anti-CD20 x Anti-CD22 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Mouse CD22 Mouse Inquiry
BSFV-MEL003 Recombinant Anti-CD19 x Anti-CD22 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Mouse CD22 Mouse Inquiry
BSFV-BGN022 Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Human CD22 Human Inquiry
BSFV-BGN021 Recombinant Human Anti-CD19 x Human Anti-CD22 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Human CD22 Human Inquiry
BSFV-BGN004 Recombinant Anti-CD20 x Anti-CD22 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Mouse CD22 Mouse Inquiry
BSFV-BGN003 Recombinant Anti-CD19 x Anti-CD22 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Mouse CD22 Mouse Inquiry
BSFV-ABR022 Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Human CD22 Human Inquiry
BSFV-ABR021 Recombinant Human Anti-CD19 x Human Anti-CD22 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Human CD22 Human Inquiry
BSFV-ABR004 Recombinant Anti-CD20 x Anti-CD22 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Mouse CD22 Mouse Inquiry
BSFV-ABR003 Recombinant Anti-CD19 x Anti-CD22 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Mouse CD22 Mouse Inquiry
BSFV-PAP022 Recombinant Human Anti-CD20 x Human Anti-CD22 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD20 Human CD22 Human Inquiry
BSFV-PAP021 Recombinant Human Anti-CD19 x Human Anti-CD22 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CD19 Human CD22 Human Inquiry
SCDB-H224 Recombinant Human Anti-CD20 x Anti-CD22 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD20 Human CD22 Human Inquiry
SCDB-H214 Recombinant Human Anti-CD19 x Anti-CD22 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Human CD22 Human Inquiry
FABIG-H224 Recombinant Human Anti-CD20 x Anti-CD22 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD20 Human CD22 Human Inquiry
FABIG-H214 Recombinant Human Anti-CD19 x Anti-CD22 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Human CD22 Human Inquiry
TRIB-H226 Recombinant Human Anti-CD20 x Anti-CD22 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD20 Human CD22 Human Inquiry
TRIB-H216 Recombinant Human Anti-CD19 x Anti-CD22 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Human CD22 Human Inquiry
BSIG-H224 Human Anti-CD20 x Anti-CD22 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD20 Human CD22 Human Inquiry
BSIG-H214 Human Anti-CD19 x Anti-CD22 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Human CD22 Human Inquiry
CROSSAB-H224 Recombinant Human Anti-CD20 x Anti-CD22 Bispecific Antibody (CrossMab) Human CrossMab CD20 Human CD22 Human Inquiry
CROSSAB-H214 Recombinant Human Anti-CD19 x Anti-CD22 Bispecific Antibody (CrossMab) Human CrossMab CD19 Human CD22 Human Inquiry
IGFV-H224 Recombinant Human Anti-CD20 x Anti-CD22 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD20 Human CD22 Human Inquiry
IGFV-H214 Recombinant Human Anti-CD19 x Anti-CD22 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Human CD22 Human Inquiry
BSDB-H224 Recombinant Human Anti-CD20 x Anti-CD22 Bispecific Antibody (Diabody) Human Diabody CD20 Human CD22 Human Inquiry
BSDB-H214 Recombinant Human Anti-CD19 x Anti-CD22 Bispecific Antibody (Diabody) Human Diabody CD19 Human CD22 Human Inquiry
BSFAB-H224 Recombinant Human Anti-CD20 x Anti-CD22 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD20 Human CD22 Human Inquiry
BSFAB-H214 Recombinant Human Anti-CD19 x Anti-CD22 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Human CD22 Human Inquiry
BSFV-H224 Recombinant Human Anti-CD20 x Anti-CD22 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD20 Human CD22 Human Inquiry
BSFV-H214 Recombinant Human Anti-CD19 x Anti-CD22 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Human CD22 Human Inquiry
SCDB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD7 Mouse Saporin Mouse Inquiry
SCDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 Mouse Saporin Mouse Inquiry
SCDB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD37 Mouse Saporin Mouse Inquiry
SCDB-049 Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD20 Mouse CD22 Mouse Inquiry
SCDB-039 Recombinant Anti-CD19 x Anti-CD22 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Mouse CD22 Mouse Inquiry
FABIG-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD7 Mouse Saporin Mouse Inquiry
FABIG-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 Mouse Saporin Mouse Inquiry
FABIG-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD37 Mouse Saporin Mouse Inquiry
FABIG-049 Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD20 Mouse CD22 Mouse Inquiry
FABIG-039 Recombinant Anti-CD19 x Anti-CD22 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Mouse CD22 Mouse Inquiry
TRIB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD7 Mouse Saporin Mouse Inquiry
TRIB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD38 Mouse Saporin Mouse Inquiry
TRIB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD37 Mouse Saporin Mouse Inquiry
TRIB-049 Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD20 Mouse CD22 Mouse Inquiry
TRIB-039 Recombinant Anti-CD19 x Anti-CD22 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Mouse CD22 Mouse Inquiry
BSIG-130 Anti-CD7 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD7 Mouse Saporin Mouse Inquiry
BSIG-120 Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 Mouse Saporin Mouse Inquiry
BSIG-118 Anti-CD37 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD37 Mouse Saporin Mouse Inquiry
BSIG-049 Anti-CD20 x Anti-CD22 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD20 Mouse CD22 Mouse Inquiry
BSIG-039 Anti-CD19 x Anti-CD22 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Mouse CD22 Mouse Inquiry
CROSSAB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD7 Mouse Saporin Mouse Inquiry
CROSSAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD38 Mouse Saporin Mouse Inquiry
CROSSAB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD37 Mouse Saporin Mouse Inquiry
CROSSAB-049 Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (CrossMab) Human CrossMab CD20 Mouse CD22 Mouse Inquiry
CROSSAB-039 Recombinant Anti-CD19 x Anti-CD22 Bispecific Antibody (CrossMab) Human CrossMab CD19 Mouse CD22 Mouse Inquiry
IGFV-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD7 Mouse Saporin Mouse Inquiry
IGFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 Mouse Saporin Mouse Inquiry
IGFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD37 Mouse Saporin Mouse Inquiry
IGFV-049 Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD20 Mouse CD22 Mouse Inquiry
IGFV-039 Recombinant Anti-CD19 x Anti-CD22 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Mouse CD22 Mouse Inquiry
BSDB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD7 Mouse Saporin Mouse Inquiry
BSDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD38 Mouse Saporin Mouse Inquiry
BSDB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD37 Mouse Saporin Mouse Inquiry
BSDB-049 Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Diabody) Human Diabody CD20 Mouse CD22 Mouse Inquiry
BSDB-039 Recombinant Anti-CD19 x Anti-CD22 Bispecific Antibody (Diabody) Human Diabody CD19 Mouse CD22 Mouse Inquiry
BSFAB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD7 Mouse Saporin Mouse Inquiry
BSFAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 Mouse Saporin Mouse Inquiry
BSFAB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD37 Mouse Saporin Mouse Inquiry
BSFAB-049 Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD20 Mouse CD22 Mouse Inquiry
BSFAB-039 Recombinant Anti-CD19 x Anti-CD22 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Mouse CD22 Mouse Inquiry
BSFV-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD7 Mouse Saporin Mouse Inquiry
BSFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 Mouse Saporin Mouse Inquiry
BSFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD37 Mouse Saporin Mouse Inquiry
BSFV-049 Recombinant Anti-CD20 x Anti-CD22 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD20 Mouse CD22 Mouse Inquiry
BSFV-039 Recombinant Anti-CD19 x Anti-CD22 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Mouse CD22 Mouse Inquiry

Background

CD22 is a cell surface protein predominantly expressed on B cells and plays a role in regulating B cell activation and survival. Saporin is a plant-derived toxin with potent ribosome-inactivating properties. The anti-CD22×anti-saporin bispecific antibody (BsAb) is a potential therapeutic agent designed to target CD22-expressing B cells using the cytotoxic properties of saporin. Upon binding to CD22, this BsAb facilitates the internalization of saporin into the B cells, where saporin exerts its cytotoxic effects by inhibiting protein synthesis, leading to cell death. This targeted approach enables the selective elimination of CD22-positive B cells while sparing non-target cells. This BsAb shows potential in the treatment of B cell malignancies, for instance, B cell lymphomas and leukemias.

Fig.1 Functions of chemical conjugates of saporin-S6 and anti-CD22 antibodies. (Polito, et al., 2017) Fig.1 The cytotoxicity of immunotoxins generated by chemical conjugation of saporin-S6 with anti-CD22 antibody.1

Reference

  1. Polito, Letizia, et al. "Two saporin-containing immunotoxins specific for CD20 and CD22 show different behavior in killing lymphoma cells." Toxins 9.6 (2017): 182.
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