CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes. CD79b/CD79B (Cluster of differentiation 79B), also referred to CD79b antigen (Immunoglobulin-associated beta), B29, IGB or AGM6, is a B lymphocyte antigen receptor complex-associated protein beta chain with 229 amino acids. It has a molecular weight of 26 kDa and is encoded by human B29 gene mapping at the chromosome 17q23.3. The protein CD79b and CD79a collectively constitute CD79. Among them, CD79b is responsible for the Ig-beta protein recognition of the B-lymphocyte antigen receptor while CD79a recognizes the Ig-alpha. Ig-alpha and Ig-beta protein, non-covalentl associated with B-cell surface Ig, are necessary for the expression and biological function of the B-lymphocyte antigen receptor. CD79 is a potent marker for B-cell lineage and is found in most types of B-cell and in some myelomas.