CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes. IGFR (Insulin-like growth factor receptor) is a protein discovered on the surface of several types of cells binding to IGF (Insulin-like growth factor). IGFR is observed at high levels on the surface of certain cancer cells, which leads these cells to growing rapidly in the presence of IGF. IGFR comprises two receptors that are IGF-1R (Insulin-like growth factor 1 receptor) and IGF-2R (Insulin-like growth factor 2 receptor). The gene of IGF-1R is located on chromosome 15q26.3 and encodes a tyrosine kinase receptor with a high-affinity for IGF. This receptor plays an essential part in transformation events of cell growth and survival. IGF-1R is over-expressed in cancer where it has anti-apoptotic activity and can enhance the malignant cell survival. IGF-2R consists of a single binding unit and its phosphorylation in whole cells is less IGF-dependent.