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CD38 & Saporin Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem Diabody) Human CD38 Saporin Inquiry
SCIGG-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scIgG) Human Single chain IgGs CD38 Saporin Inquiry
FVTIG-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv4-Ig) Human Appended IgGs CD38 Saporin Inquiry
BSSG-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-IgG) Human Appended IgGs CD38 Saporin Inquiry
IGLFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs CD38 Saporin Inquiry
BSGV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-Fv) Human IgG-Fv CD38 Saporin Inquiry
BSDG-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fv-IgG) Human Appended IgGs CD38 Saporin Inquiry
BABFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins CD38 Saporin Inquiry
FABVC-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins CD38 Saporin Inquiry
SCDBC-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments CD38 Saporin Inquiry
BSDBC-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments CD38 Saporin Inquiry
SCDBF-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments CD38 Saporin Inquiry
BSFVF-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments CD38 Saporin Inquiry
BSDBF-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments CD38 Saporin Inquiry
BSTF-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD38 Saporin Inquiry
BSCFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-Fc) Human scFv-Fc CD38 Saporin Inquiry
MNAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Miniantibody) Human Miniantibody CD38 Saporin Inquiry
BSFC-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD38 Saporin Inquiry
BSCC-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD38 Saporin Inquiry
BIBD-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD38 Saporin Inquiry
FABFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 Saporin Inquiry
MiniB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD38 Saporin Inquiry
SCDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 Saporin Inquiry
FABIG-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 Saporin Inquiry
TRIB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Triple Body) Human Triple Body CD38 Saporin Inquiry
BSIG-120 Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 Saporin Inquiry
CROSSAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD38 Saporin Inquiry
IGFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 Saporin Inquiry
BSDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD38 Saporin Inquiry
BSFAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 Saporin Inquiry
BSFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 Saporin Inquiry
MNAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
MNAB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Miniantibody) Human Miniantibody CD37 Saporin Inquiry
MNAB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Miniantibody) Human Miniantibody CD22 Saporin Inquiry
BSFC-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
BSFC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSFC-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
BSFC-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD7 Saporin Inquiry
BSFC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSFC-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD37 Saporin Inquiry
BSFC-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD22 Saporin Inquiry
BSCC-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
BSCC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSCC-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
BSCC-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD7 Saporin Inquiry
BSCC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSCC-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD37 Saporin Inquiry
BSCC-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD22 Saporin Inquiry
BIBD-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Bibody) Human Bibody CD3 CD38 Inquiry
BIBD-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD38 CD59 Inquiry
BIBD-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Bibody) Human Bibody CD3 CD38 Inquiry
BIBD-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD7 Saporin Inquiry
BIBD-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD38 CD59 Inquiry
BIBD-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD37 Saporin Inquiry
BIBD-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD22 Saporin Inquiry
FABFV-H353 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 CD38 Inquiry
FABFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 CD59 Inquiry
FABFV-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 CD38 Inquiry
FABFV-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD7 Saporin Inquiry
FABFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 CD59 Inquiry
FABFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD37 Saporin Inquiry
FABFV-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD22 Saporin Inquiry
MiniB-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Minibody) Human Minibody CD3 CD38 Inquiry
MiniB-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD38 CD59 Inquiry
MiniB-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Minibody) Human Minibody CD3 CD38 Inquiry
MiniB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD7 Saporin Inquiry
MiniB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD38 CD59 Inquiry
MiniB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD37 Saporin Inquiry
MiniB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD22 Saporin Inquiry
SCTB-H184 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD38 CD59 Inquiry
SCDB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 CD59 Inquiry
FABIG-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 CD59 Inquiry
TRIB-H294 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Triple Body) Human Triple Body CD38 CD59 Inquiry
BSIG-H292 Human Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 CD59 Inquiry
CROSSAB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD38 CD59 Inquiry
IGFV-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 CD59 Inquiry
BSDB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD38 CD59 Inquiry
BSFAB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 CD59 Inquiry
BSFV-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 CD59 Inquiry
SCTB-089 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD38 CD59 Inquiry
SCDB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD7 Saporin Inquiry
SCDB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 CD59 Inquiry
SCDB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD37 Saporin Inquiry
SCDB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD22 Saporin Inquiry
FABIG-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD7 Saporin Inquiry
FABIG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 CD59 Inquiry
FABIG-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD37 Saporin Inquiry
FABIG-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD22 Saporin Inquiry
TRIB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Triple Body) Human Triple Body CD7 Saporin Inquiry
TRIB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Triple Body) Human Triple Body CD38 CD59 Inquiry
TRIB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Triple Body) Human Triple Body CD37 Saporin Inquiry
TRIB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Triple Body) Human Triple Body CD22 Saporin Inquiry
BSIG-130 Anti-CD7 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD7 Saporin Inquiry
BSIG-119 Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 CD59 Inquiry
BSIG-118 Anti-CD37 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD37 Saporin Inquiry
BSIG-053 Anti-CD22 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD22 Saporin Inquiry
CROSSAB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD7 Saporin Inquiry
CROSSAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD38 CD59 Inquiry
CROSSAB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD37 Saporin Inquiry
CROSSAB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD22 Saporin Inquiry
IGFV-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD7 Saporin Inquiry
IGFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 CD59 Inquiry
IGFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD37 Saporin Inquiry
IGFV-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD22 Saporin Inquiry
BSDB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD7 Saporin Inquiry
BSDB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD38 CD59 Inquiry
BSDB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD37 Saporin Inquiry
BSDB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD22 Saporin Inquiry
BSFAB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD7 Saporin Inquiry
BSFAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 CD59 Inquiry
BSFAB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD37 Saporin Inquiry
BSFAB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD22 Saporin Inquiry
BSFV-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD7 Saporin Inquiry
BSFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 CD59 Inquiry
BSFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD37 Saporin Inquiry
BSFV-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD22 Saporin Inquiry

Background

CD38, a glycoprotein expressed on the surface of various immune cells, including B cells, T cells, and plasma cells, plays a crucial role in immune regulation, cell signaling, and antibody production. Saporin, a ribosome-inactivating protein derived from the seeds of Saponaria officinalis, possesses strong cytotoxic properties. When conjugated with targeting molecules, such as antibodies or ligands, saporin can selectively bind to specific cells expressing the corresponding receptors. Once internalized, saporin inhibits protein synthesis, leading to cell death. The anti-CD38×anti-saporin bispecific antibody (BsAb) can selectively bind to CD38-expressing cells, such as cancer cells or immune cells, and deliver saporin specifically to these cells, resulting in their elimination. This BsAb holds potential for optimizing the treatment of CD38-positive malignancies, including multiple myeloma and certain types of leukemia.

Fig.1 CD38 and saporin structures. (Egea, et al., 2012; Giansanti, et al., 2018) Fig.1 Structures of CD38 and saporin.1,2

References

  1. Egea, Pascal F., et al. "Insights into the mechanism of bovine CD38/NAD+ glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates." PLoS One 7.4 (2012): e34918.
  2. Giansanti, Francesco, et al. "Strategies to improve the clinical utility of saporin-based targeted toxins." Toxins 10.2 (2018): 82.
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