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CD44 & EPCAM Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0825-JL73 Anti-CD44 x Anti-EPCAM Bispecific aptamer (RNA/RNA) Human Bispecific Aptamer CD44 EPCAM Inquiry
TRIB-H235 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Human EPCAM Human Inquiry
TRIB-H233 Recombinant Human Anti-CD28 x Anti-CD44 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Human CD44 Human Inquiry
BSIG-H293 Human Anti-CD44 x Anti-CR3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD44 Human CR3 Human Inquiry
BSIG-H253 Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human EPCAM Human Inquiry
BSIG-H242 Human Anti-CD3 x Anti-CD44 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human CD44 Human Inquiry
BSIG-H233 Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Human EPCAM Human Inquiry
BSIG-H231 Human Anti-CD28 x Anti-CD44 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Human CD44 Human Inquiry
CROSSAB-H293 Recombinant Human Anti-CD44 x Anti-CR3 Bispecific Antibody (CrossMab) Human CrossMab CD44 Human CR3 Human Inquiry
CROSSAB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD3 Human EPCAM Human Inquiry
CROSSAB-H242 Recombinant Human Anti-CD3 x Anti-CD44 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human CD44 Human Inquiry
CROSSAB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD28 Human EPCAM Human Inquiry
CROSSAB-H231 Recombinant Human Anti-CD28 x Anti-CD44 Bispecific Antibody (CrossMab) Human CrossMab CD28 Human CD44 Human Inquiry
IGFV-H293 Recombinant Human Anti-CD44 x Anti-CR3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD44 Human CR3 Human Inquiry
IGFV-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human EPCAM Human Inquiry
IGFV-H242 Recombinant Human Anti-CD3 x Anti-CD44 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human CD44 Human Inquiry
IGFV-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Human EPCAM Human Inquiry
IGFV-H231 Recombinant Human Anti-CD28 x Anti-CD44 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Human CD44 Human Inquiry
BSDB-H293 Recombinant Human Anti-CD44 x Anti-CR3 Bispecific Antibody (Diabody) Human Diabody CD44 Human CR3 Human Inquiry
BSDB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD3 Human EPCAM Human Inquiry
BSDB-H242 Recombinant Human Anti-CD3 x Anti-CD44 Bispecific Antibody (Diabody) Human Diabody CD3 Human CD44 Human Inquiry
BSDB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD28 Human EPCAM Human Inquiry
BSDB-H231 Recombinant Human Anti-CD28 x Anti-CD44 Bispecific Antibody (Diabody) Human Diabody CD28 Human CD44 Human Inquiry
BSFAB-H293 Recombinant Human Anti-CD44 x Anti-CR3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD44 Human CR3 Human Inquiry
BSFAB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human EPCAM Human Inquiry
BSFAB-H242 Recombinant Human Anti-CD3 x Anti-CD44 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human CD44 Human Inquiry
BSFAB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Human EPCAM Human Inquiry
BSFAB-H231 Recombinant Human Anti-CD28 x Anti-CD44 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Human CD44 Human Inquiry
BSFV-H293 Recombinant Human Anti-CD44 x Anti-CR3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD44 Human CR3 Human Inquiry
BSFV-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human EPCAM Human Inquiry
BSFV-H242 Recombinant Human Anti-CD3 x Anti-CD44 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human CD44 Human Inquiry
BSFV-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Human EPCAM Human Inquiry
BSFV-H231 Recombinant Human Anti-CD28 x Anti-CD44 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Human CD44 Human Inquiry
SCTB-090 Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD44 Mouse CR3 Mouse Inquiry
SCTB-052 Recombinant Anti-EPCAM x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse EPCAM Mouse Inquiry
SCTB-040 Recombinant Anti-CD44 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse CD44 Mouse Inquiry
SCTB-031 Recombinant Anti-EPCAM x Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Mouse EPCAM Mouse Inquiry
SCTB-029 Recombinant Anti-CD44 x Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Mouse CD44 Mouse Inquiry
SCDB-121 Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD44 Mouse CR3 Mouse Inquiry
SCDB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse EPCAM Mouse Inquiry
SCDB-068 Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse CD44 Mouse Inquiry
SCDB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Mouse EPCAM Mouse Inquiry
SCDB-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Mouse CD44 Mouse Inquiry
SCDB-013 Recombinant Anti-B Cell Lymphoma 38C13 Idiotype x Anti-CD44 Bispecific Antibody (Single-chain Diabody) Mouse Single-chain Diabody B Cell Lymphoma 38C13 Idiotype Rat CD44 Rat Inquiry
SCDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob Mouse EPCAM Mouse Inquiry
FABIG-121 Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD44 Mouse CR3 Mouse Inquiry
FABIG-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse EPCAM Mouse Inquiry
FABIG-068 Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse CD44 Mouse Inquiry
FABIG-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse EPCAM Mouse Inquiry
FABIG-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse CD44 Mouse Inquiry
FABIG-013 Recombinant Anti-B Cell Lymphoma 38C13 Idiotype x Anti-CD44 Bispecific Antibody (Fab-IgG) Mouse Fab-IgG B Cell Lymphoma 38C13 Idiotype Rat CD44 Rat Inquiry
FABIG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob Mouse EPCAM Mouse Inquiry
TRIB-121 Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD44 Mouse CR3 Mouse Inquiry
TRIB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse EPCAM Mouse Inquiry
TRIB-068 Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse CD44 Mouse Inquiry
TRIB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse EPCAM Mouse Inquiry
TRIB-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse CD44 Mouse Inquiry
TRIB-013 Recombinant Anti-B Cell Lymphoma 38C13 Idiotype x Anti-CD44 Bispecific Antibody (Fab-scFv-scFv) Mouse Fab-scFv-scFv B Cell Lymphoma 38C13 Idiotype Rat CD44 Rat Inquiry
TRIB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Ad Fiber Knob Mouse EPCAM Mouse Inquiry
BSIG-121 Anti-CD44 x Anti-CR3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD44 Mouse CR3 Mouse Inquiry
BSIG-079 Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse EPCAM Mouse Inquiry
BSIG-068 Anti-CD3 x Anti-CD44 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse CD44 Mouse Inquiry
BSIG-059 Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse EPCAM Mouse Inquiry
BSIG-057 Anti-CD28 x Anti-CD44 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse CD44 Mouse Inquiry
BSIG-013 Anti-B Cell Lymphoma 38C13 Idiotype x Anti-CD44 Bispecific Antibody (IgG-IgG) Mouse IgG-IgG B Cell Lymphoma 38C13 Idiotype Rat CD44 Rat Inquiry
BSIG-004 Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob Mouse EPCAM Mouse Inquiry
CROSSAB-121 Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (CrossMab) Human CrossMab CD44 Mouse CR3 Mouse Inquiry
CROSSAB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse EPCAM Mouse Inquiry
CROSSAB-068 Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse CD44 Mouse Inquiry
CROSSAB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse EPCAM Mouse Inquiry
CROSSAB-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse CD44 Mouse Inquiry
CROSSAB-013 Recombinant Anti-B Cell Lymphoma 38C13 Idiotype x Anti-CD44 Bispecific Antibody (CrossMab) Mouse CrossMab B Cell Lymphoma 38C13 Idiotype Rat CD44 Rat Inquiry
CROSSAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob Mouse EPCAM Mouse Inquiry
IGFV-121 Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD44 Mouse CR3 Mouse Inquiry
IGFV-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse EPCAM Mouse Inquiry
IGFV-068 Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse CD44 Mouse Inquiry
IGFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse EPCAM Mouse Inquiry
IGFV-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse CD44 Mouse Inquiry
IGFV-013 Recombinant Anti-B Cell Lymphoma 38C13 Idiotype x Anti-CD44 Bispecific Antibody (IgG-scFv) Mouse IgG-scFv B Cell Lymphoma 38C13 Idiotype Rat CD44 Rat Inquiry
IGFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob Mouse EPCAM Mouse Inquiry
BSDB-121 Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Diabody) Human Diabody CD44 Mouse CR3 Mouse Inquiry
BSDB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD3 Mouse EPCAM Mouse Inquiry
BSDB-068 Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse CD44 Mouse Inquiry
BSDB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD28 Mouse EPCAM Mouse Inquiry
BSDB-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse CD44 Mouse Inquiry
BSDB-013 Recombinant Anti-B Cell Lymphoma 38C13 Idiotype x Anti-CD44 Bispecific Antibody (Diabody) Mouse Diabody B Cell Lymphoma 38C13 Idiotype Rat CD44 Rat Inquiry
BSDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob Mouse EPCAM Mouse Inquiry
BSFAB-121 Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD44 Mouse CR3 Mouse Inquiry
BSFAB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse EPCAM Mouse Inquiry
BSFAB-068 Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse CD44 Mouse Inquiry
BSFAB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse EPCAM Mouse Inquiry
BSFAB-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse CD44 Mouse Inquiry
BSFAB-013 Recombinant Anti-B Cell Lymphoma 38C13 Idiotype x Anti-CD44 Bispecific Antibody (Tandem Fab) Mouse Tandem Fab B Cell Lymphoma 38C13 Idiotype Rat CD44 Rat Inquiry
BSFAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob Mouse EPCAM Mouse Inquiry
BSFV-121 Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD44 Mouse CR3 Mouse Inquiry
BSFV-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse EPCAM Mouse Inquiry
BSFV-068 Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse CD44 Mouse Inquiry
BSFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse EPCAM Mouse Inquiry
BSFV-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse CD44 Mouse Inquiry
BSFV-013 Recombinant Anti-B Cell Lymphoma 38C13 Idiotype x Anti-CD44 Bispecific Antibody (Tandem scFv) Mouse Tandem scFv B Cell Lymphoma 38C13 Idiotype Rat CD44 Rat Inquiry
BSFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob Mouse EPCAM Mouse Inquiry

Background

CD44 and EPCAM (epithelial cell adhesion molecule) are pivotal targets in oncology research. CD44, a transmembrane glycoprotein, exists as standard (CD44s) or variant isoforms (CD44v). It regulates cell adhesion, metastasis, and epithelial-mesenchymal transition (EMT), serving as a cancer stem cell marker linked to tumor aggressiveness. EPCAM, another cell-surface protein, drives epithelial tumor proliferation and metastasis by modulating intracellular signaling pathways. Dual-targeting bispecific antibodies (BsAbs) against CD44&EPCAM disrupt tumorigenic cross-talk between these markers, simultaneously blocking metastasis-initiating niches and EMT-driven plasticity. These BsAbs enhance tumor-specific cytotoxicity and immune recruitment, showing therapeutic potential in gastric, colorectal, and breast cancers with high CD44/EPCAM co-expression profiles. Their mechanism includes dual receptor internalization and stromal matrix disassembly, offering precision in targeting heterogeneous tumor populations.

Signaling pathways engaging the CD44 and EpCAM in cancer cells (OA Literature)Fig.1 Signaling pathways of the CD44 and EpCAM.1,2,3

References

  1. Szatanek, Rafał, and Monika Baj-Krzyworzeka. "CD44 and Tumor-Derived Extracellular Vesicles (TEVs). Possible Gateway to Cancer Metastasis." International Journal of Molecular Sciences vol. 22,3 1463. 2 Feb. 2021, doi:10.3390/ijms22031463.
  2. Mohtar, M Aiman et al. "Revisiting the Roles of Pro-Metastatic EpCAM in Cancer." Biomolecules vol. 10,2 255. 7 Feb. 2020, doi:10.3390/biom10020255.
  3. Distributed under Open Access license CC BY 4.0, without modification.
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