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CD55 & HLA-A Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H296 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD55 Human HLA-A Human Inquiry
T-BSDB-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD55 Mouse HLA-A Mouse Inquiry
SCIGG-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (scIgG) Human Single chain IgGs CD55 Human HLA-A Human Inquiry
SCIGG-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (scIgG) Human Single chain IgGs CD55 Mouse HLA-A Mouse Inquiry
FVTIG-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD55 Human HLA-A Human Inquiry
FVTIG-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD55 Mouse HLA-A Mouse Inquiry
BSSG-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (scFv-IgG) Human scFv-IgG CD55 Human HLA-A Human Inquiry
BSSG-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (scFv-IgG) Human scFv-IgG CD55 Mouse HLA-A Mouse Inquiry
IGLFV-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD55 Human HLA-A Human Inquiry
IGLFV-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD55 Mouse HLA-A Mouse Inquiry
BSGV-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (IgG-Fv) Human IgG-Fv CD55 Mouse HLA-A Mouse Inquiry
BSGV-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (IgG-Fv) Human IgG-Fv CD55 Mouse HLA-A Mouse Inquiry
BSDG-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (Fv-IgG) Human Fv-IgG CD55 Human HLA-A Human Inquiry
BSDG-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Fv-IgG) Human Fv-IgG CD55 Mouse HLA-A Mouse Inquiry
BABFV-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD55 Human HLA-A Human Inquiry
BABFV-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD55 Mouse HLA-A Mouse Inquiry
FABVC-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD55 Human HLA-A Human Inquiry
FABVC-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD55 Mouse HLA-A Mouse Inquiry
SCDBC-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD55 Human HLA-A Human Inquiry
SCDBC-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD55 Mouse HLA-A Mouse Inquiry
BSDBC-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD55 Human HLA-A Human Inquiry
BSDBC-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD55 Mouse HLA-A Mouse Inquiry
SCDBF-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD55 Human HLA-A Human Inquiry
SCDBF-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD55 Mouse HLA-A Mouse Inquiry
BSFVF-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD55 Human HLA-A Human Inquiry
BSFVF-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD55 Mouse HLA-A Mouse Inquiry
BSDBF-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD55 Human HLA-A Human Inquiry
BSDBF-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD55 Mouse HLA-A Mouse Inquiry
BSTF-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD55 Mouse HLA-A Mouse Inquiry
BSTF-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD55 Mouse HLA-A Mouse Inquiry
BSCFV-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (scFv-Fc) Human scFv-Fc CD55 Mouse HLA-A Mouse Inquiry
BSCFV-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (scFv-Fc) Human scFv-Fc CD55 Mouse HLA-A Mouse Inquiry
MNAB-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (Miniantibody) Human Miniantibody CD55 Mouse HLA-A Mouse Inquiry
MNAB-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Miniantibody) Human Miniantibody CD55 Mouse HLA-A Mouse Inquiry
BSFC-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD55 Mouse HLA-A Mouse Inquiry
BSFC-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD55 Mouse HLA-A Mouse Inquiry
BSCC-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD55 Mouse HLA-A Mouse Inquiry
BSCC-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD55 Mouse HLA-A Mouse Inquiry
BIBD-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (Bibody) Human Bibody CD55 Mouse HLA-A Mouse Inquiry
BIBD-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Bibody) Human Bibody CD55 Mouse HLA-A Mouse Inquiry
FABFV-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (Fab-Fv) Human Fab-Fv CD55 Human HLA-A Human Inquiry
FABFV-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Fab-Fv) Human Fab-Fv CD55 Mouse HLA-A Mouse Inquiry
MiniB-H298 Recombinant Human Anti-CD55 x Human Anti-HLA-A Bispecific Antibody (Minibody) Human Minibody CD55 Human HLA-A Human Inquiry
MiniB-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Minibody) Human Minibody CD55 Mouse HLA-A Mouse Inquiry
SCTB-H187 Recombinant Human Anti-HLA-A x Human Anti-CD55 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD55 Human HLA-A Human Inquiry
SCDB-H296 Recombinant Human Anti-CD55 x Anti-HLA-A Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD55 Human HLA-A Human Inquiry
FABIG-H296 Recombinant Human Anti-CD55 x Anti-HLA-A Bispecific Antibody (Fab-IgG) Human Fab-IgG CD55 Human HLA-A Human Inquiry
TRIB-H298 Recombinant Human Anti-CD55 x Anti-HLA-A Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD55 Human HLA-A Human Inquiry
BSIG-H296 Human Anti-CD55 x Anti-HLA-A Bispecific Antibody (IgG-IgG) Human IgG-IgG CD55 Human HLA-A Human Inquiry
CROSSAB-H296 Recombinant Human Anti-CD55 x Anti-HLA-A Bispecific Antibody (CrossMab) Human CrossMab CD55 Human HLA-A Human Inquiry
IGFV-H296 Recombinant Human Anti-CD55 x Anti-HLA-A Bispecific Antibody (IgG-scFv) Human IgG-scFv CD55 Human HLA-A Human Inquiry
BSDB-H296 Recombinant Human Anti-CD55 x Anti-HLA-A Bispecific Antibody (Diabody) Human Diabody CD55 Human HLA-A Human Inquiry
BSFAB-H296 Recombinant Human Anti-CD55 x Anti-HLA-A Bispecific Antibody (Tandem Fab) Human Tandem Fab CD55 Human HLA-A Human Inquiry
BSFV-H296 Recombinant Human Anti-CD55 x Anti-HLA-A Bispecific Antibody (Tandem scFv) Human Tandem scFv CD55 Human HLA-A Human Inquiry
SCTB-092 Recombinant Anti-HLA-A x Anti-CD55 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD55 Mouse HLA-A Mouse Inquiry
SCDB-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD55 Mouse HLA-A Mouse Inquiry
FABIG-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Fab-IgG) Human Fab-IgG CD55 Mouse HLA-A Mouse Inquiry
TRIB-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD55 Mouse HLA-A Mouse Inquiry
BSIG-124 Anti-CD55 x Anti-HLA-A Bispecific Antibody (IgG-IgG) Human IgG-IgG CD55 Mouse HLA-A Mouse Inquiry
CROSSAB-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (CrossMab) Human CrossMab CD55 Mouse HLA-A Mouse Inquiry
IGFV-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (IgG-scFv) Human IgG-scFv CD55 Mouse HLA-A Mouse Inquiry
BSDB-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Diabody) Human Diabody CD55 Mouse HLA-A Mouse Inquiry
BSFAB-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Tandem Fab) Human Tandem Fab CD55 Mouse HLA-A Mouse Inquiry
BSFV-124 Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Tandem scFv) Human Tandem scFv CD55 Mouse HLA-A Mouse Inquiry
BABFV-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD55 Human CA9 Human Inquiry
BABFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD55 Mouse CA9 Mouse Inquiry
FABVC-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD55 Human CA9 Human Inquiry
FABVC-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD55 Mouse CA9 Mouse Inquiry
SCDBC-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD55 Human CA9 Human Inquiry
SCDBC-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD55 Mouse CA9 Mouse Inquiry
BSDBC-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD55 Human CA9 Human Inquiry
BSDBC-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD55 Mouse CA9 Mouse Inquiry
SCDBF-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD55 Human CA9 Human Inquiry
SCDBF-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD55 Mouse CA9 Mouse Inquiry
BSFVF-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD55 Human CA9 Human Inquiry
BSFVF-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD55 Mouse CA9 Mouse Inquiry
BSDBF-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD55 Human CA9 Human Inquiry
BSDBF-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD55 Mouse CA9 Mouse Inquiry
BSTF-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD55 Mouse CA9 Mouse Inquiry
BSTF-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD55 Mouse CA9 Mouse Inquiry
BSCFV-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD55 Mouse CA9 Mouse Inquiry
BSCFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD55 Mouse CA9 Mouse Inquiry
MNAB-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Miniantibody) Human Miniantibody CD55 Mouse CA9 Mouse Inquiry
MNAB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Miniantibody) Human Miniantibody CD55 Mouse CA9 Mouse Inquiry
BSFC-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD55 Mouse CA9 Mouse Inquiry
BSFC-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD55 Mouse CA9 Mouse Inquiry
BSCC-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD55 Mouse CA9 Mouse Inquiry
BSCC-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD55 Mouse CA9 Mouse Inquiry
BIBD-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Bibody) Human Bibody CD55 Mouse CA9 Mouse Inquiry
BIBD-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Bibody) Human Bibody CD55 Mouse CA9 Mouse Inquiry
FABFV-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD55 Human CA9 Human Inquiry
FABFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD55 Mouse CA9 Mouse Inquiry
MiniB-H297 Recombinant Human Anti-CD55 x Human Anti-CA9 Bispecific Antibody (Minibody) Human Minibody CD55 Human CA9 Human Inquiry
MiniB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Minibody) Human Minibody CD55 Mouse CA9 Mouse Inquiry
SCTB-H186 Recombinant Human Anti-CA9 x Human Anti-CD55 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD55 Human CA9 Human Inquiry
SCDB-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD55 Human CA9 Human Inquiry
FABIG-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD55 Human CA9 Human Inquiry
TRIB-H297 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD55 Human CA9 Human Inquiry
BSIG-H295 Human Anti-CD55 x Anti-CA9 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD55 Human CA9 Human Inquiry
CROSSAB-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (CrossMab) Human CrossMab CD55 Human CA9 Human Inquiry
IGFV-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD55 Human CA9 Human Inquiry
BSDB-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Diabody) Human Diabody CD55 Human CA9 Human Inquiry
BSFAB-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD55 Human CA9 Human Inquiry
BSFV-H295 Recombinant Human Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD55 Human CA9 Human Inquiry
SCTB-091 Recombinant Anti-CA9 x Anti-CD55 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD55 Mouse CA9 Mouse Inquiry
SCDB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD55 Mouse CA9 Mouse Inquiry
FABIG-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD55 Mouse CA9 Mouse Inquiry
TRIB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD55 Mouse CA9 Mouse Inquiry
BSIG-123 Anti-CD55 x Anti-CA9 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD55 Mouse CA9 Mouse Inquiry
CROSSAB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (CrossMab) Human CrossMab CD55 Mouse CA9 Mouse Inquiry
IGFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD55 Mouse CA9 Mouse Inquiry
BSDB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Diabody) Human Diabody CD55 Mouse CA9 Mouse Inquiry
BSFAB-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD55 Mouse CA9 Mouse Inquiry
BSFV-123 Recombinant Anti-CD55 x Anti-CA9 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD55 Mouse CA9 Mouse Inquiry

Background

CD55, also known as decay-accelerating factor (DAF), is a cell surface glycoprotein that can regulate the complement system by accelerating the decay of C3/C5 convertases and preventing the formation of membrane attack complexes. HLA-A (human leukocyte antigen-A) is a major histocompatibility complex (MHC) class I molecule that participates in antigen presentation to T cells. HLA-A is important in the adaptive immune response because it presents intracellular antigens to cytotoxic T cells, prompting an immunological response against infected or aberrant cells. The anti-CD55×anti-HLA-A bispecific antibody can be constructed to bind to both CD55 and HLA-A on the surface of cancer cells at the same time. By doing so, they can activate T cells and natural killer cells, causing cancer cells apoptosis. This approach can be applied in research of various solid tumor therapies.

Fig.1 Functions of CD55 and HLA-A. (Geller and Jun, 2019; Vijayan, et al., 2019) Fig.1 Molecular mechanisms of CD55 and HLA-A.1,2

References

  1. Geller, Anne, and Jun Yan. "The role of membrane bound complement regulatory proteins in tumor development and cancer immunotherapy." Frontiers in Immunology 10 (2019): 1074.
  2. Vijayan, Saptha, et al. "Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance." Immunogenetics 71.3 (2019): 273-282.
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