CLDN18.2 Bispecific Antibodies

Product List Background

Product List

CAT#	Product Name	Species Reactivity	BsAb Type	Target 1	Host Animal 1	Target 2	Host Animal 2	INQUIRY
KN-0825-N40	Recombinant Human Anti-CLDN18.2 x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc)	Human	Fab-scFv/sdAb-Fc	CLDN18.2	Human	4-1BB	Human	Inquiry
KN-0825-N11	Recombinant Human Anti-CLDN18.2 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv)	Human	IgG-scFv	CLDN18.2	Human	4-1BB	Human	Inquiry

Background

CLDN18.2, a member of the Claudin family of tight junction proteins, is a transmembrane structural protein critical for maintaining epithelial barrier integrity. Under normal physiological conditions, CLDN18.2 exhibits highly restricted expression in the differentiated epithelial cells of gastric mucosa, where its epitopes remain largely inaccessible due to intercellular tight junctions. However, malignant transformation disrupts cellular polarity and tight junction architecture, leading to CLDN18.2 overexpression and surface exposure in 16-86% of gastric adenocarcinomas, 60% of pancreatic tumors, and subsets of esophageal, ovarian, and lung cancers. This tumor-selective expression pattern, combined with preserved membrane localization in neoplastic cells, makes CLDN18.2 a compelling therapeutic target.

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