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CSPG4 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BSCFV-H325 Recombinant Human Anti-FAS x Human Anti-CSPG4 Bispecific Antibody (scFv-Fc) Human scFv-Fc FAS Mouse CSPG4 Mouse Inquiry
BSCFV-H270 Recombinant Human Anti-CD3 x Human Anti-CSPG4 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse CSPG4 Mouse Inquiry
BSCFV-H239 Recombinant Human Anti-CD28 x Human Anti-CSPG4 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD28 Mouse CSPG4 Mouse Inquiry
BSCFV-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (scFv-Fc) Human scFv-Fc FAS Mouse CSPG4 Mouse Inquiry
BSCFV-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse CSPG4 Mouse Inquiry
BSCFV-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD28 Mouse CSPG4 Mouse Inquiry
MNAB-H325 Recombinant Human Anti-FAS x Human Anti-CSPG4 Bispecific Antibody (Miniantibody) Human Miniantibody FAS Mouse CSPG4 Mouse Inquiry
MNAB-H270 Recombinant Human Anti-CD3 x Human Anti-CSPG4 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse CSPG4 Mouse Inquiry
MNAB-H239 Recombinant Human Anti-CD28 x Human Anti-CSPG4 Bispecific Antibody (Miniantibody) Human Miniantibody CD28 Mouse CSPG4 Mouse Inquiry
MNAB-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Miniantibody) Human Miniantibody FAS Mouse CSPG4 Mouse Inquiry
MNAB-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse CSPG4 Mouse Inquiry
MNAB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Miniantibody) Human Miniantibody CD28 Mouse CSPG4 Mouse Inquiry
BSFC-H325 Recombinant Human Anti-FAS x Human Anti-CSPG4 Bispecific Antibody (scFv-CH3) Human scFv-CH3 FAS Mouse CSPG4 Mouse Inquiry
BSFC-H270 Recombinant Human Anti-CD3 x Human Anti-CSPG4 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse CSPG4 Mouse Inquiry
BSFC-H239 Recombinant Human Anti-CD28 x Human Anti-CSPG4 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD28 Mouse CSPG4 Mouse Inquiry
BSFC-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (scFv-CH3) Human scFv-CH3 FAS Mouse CSPG4 Mouse Inquiry
BSFC-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse CSPG4 Mouse Inquiry
BSFC-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD28 Mouse CSPG4 Mouse Inquiry
BSCC-H325 Recombinant Human Anti-FAS x Human Anti-CSPG4 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL FAS Mouse CSPG4 Mouse Inquiry
BSCC-H270 Recombinant Human Anti-CD3 x Human Anti-CSPG4 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse CSPG4 Mouse Inquiry
BSCC-H239 Recombinant Human Anti-CD28 x Human Anti-CSPG4 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD28 Mouse CSPG4 Mouse Inquiry
BSCC-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL FAS Mouse CSPG4 Mouse Inquiry
BSCC-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse CSPG4 Mouse Inquiry
BSCC-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD28 Mouse CSPG4 Mouse Inquiry
BIBD-H325 Recombinant Human Anti-FAS x Human Anti-CSPG4 Bispecific Antibody (Bibody) Human Bibody FAS Mouse CSPG4 Mouse Inquiry
BIBD-H270 Recombinant Human Anti-CD3 x Human Anti-CSPG4 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse CSPG4 Mouse Inquiry
BIBD-H239 Recombinant Human Anti-CD28 x Human Anti-CSPG4 Bispecific Antibody (Bibody) Human Bibody CD28 Mouse CSPG4 Mouse Inquiry
BIBD-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Bibody) Human Bibody FAS Mouse CSPG4 Mouse Inquiry
BIBD-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse CSPG4 Mouse Inquiry
BIBD-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Bibody) Human Bibody CD28 Mouse CSPG4 Mouse Inquiry
FABFV-H325 Recombinant Human Anti-FAS x Human Anti-CSPG4 Bispecific Antibody (Fab-Fv) Human Fab-Fv FAS Human CSPG4 Human Inquiry
FABFV-H270 Recombinant Human Anti-CD3 x Human Anti-CSPG4 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human CSPG4 Human Inquiry
FABFV-H239 Recombinant Human Anti-CD28 x Human Anti-CSPG4 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 Human CSPG4 Human Inquiry
FABFV-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Fab-Fv) Human Fab-Fv FAS Mouse CSPG4 Mouse Inquiry
FABFV-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse CSPG4 Mouse Inquiry
FABFV-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 Mouse CSPG4 Mouse Inquiry
MiniB-H325 Recombinant Human Anti-FAS x Human Anti-CSPG4 Bispecific Antibody (Minibody) Human Minibody FAS Human CSPG4 Human Inquiry
MiniB-H270 Recombinant Human Anti-CD3 x Human Anti-CSPG4 Bispecific Antibody (Minibody) Human Minibody CD3 Human CSPG4 Human Inquiry
MiniB-H239 Recombinant Human Anti-CD28 x Human Anti-CSPG4 Bispecific Antibody (Minibody) Human Minibody CD28 Human CSPG4 Human Inquiry
MiniB-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Minibody) Human Minibody FAS Mouse CSPG4 Mouse Inquiry
MiniB-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse CSPG4 Mouse Inquiry
MiniB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Minibody) Human Minibody CD28 Mouse CSPG4 Mouse Inquiry
SCTB-H164 Recombinant Human Anti-CSPG4 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human CSPG4 Human Inquiry
SCTB-H133 Recombinant Human Anti-CSPG4 x Human Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Human CSPG4 Human Inquiry
SCDB-H324 Recombinant Human Anti-FAS x Anti-CSPG4 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody FAS Human CSPG4 Human Inquiry
SCDB-H268 Recombinant Human Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human CSPG4 Human Inquiry
SCDB-H237 Recombinant Human Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Human CSPG4 Human Inquiry
FABIG-H324 Recombinant Human Anti-FAS x Anti-CSPG4 Bispecific Antibody (Fab-IgG) Human Fab-IgG FAS Human CSPG4 Human Inquiry
FABIG-H268 Recombinant Human Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human CSPG4 Human Inquiry
FABIG-H237 Recombinant Human Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Human CSPG4 Human Inquiry
TRIB-H326 Recombinant Human Anti-FAS x Anti-CSPG4 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv FAS Human CSPG4 Human Inquiry
TRIB-H270 Recombinant Human Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human CSPG4 Human Inquiry
TRIB-H239 Recombinant Human Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Human CSPG4 Human Inquiry
BSIG-H324 Human Anti-FAS x Anti-CSPG4 Bispecific Antibody (IgG-IgG) Human IgG-IgG FAS Human CSPG4 Human Inquiry
BSIG-H268 Human Anti-CD3 x Anti-CSPG4 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human CSPG4 Human Inquiry
BSIG-H237 Human Anti-CD28 x Anti-CSPG4 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Human CSPG4 Human Inquiry
CROSSAB-H324 Recombinant Human Anti-FAS x Anti-CSPG4 Bispecific Antibody (CrossMab) Human CrossMab FAS Human CSPG4 Human Inquiry
CROSSAB-H268 Recombinant Human Anti-CD3 x Anti-CSPG4 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human CSPG4 Human Inquiry
CROSSAB-H237 Recombinant Human Anti-CD28 x Anti-CSPG4 Bispecific Antibody (CrossMab) Human CrossMab CD28 Human CSPG4 Human Inquiry
IGFV-H324 Recombinant Human Anti-FAS x Anti-CSPG4 Bispecific Antibody (IgG-scFv) Human IgG-scFv FAS Human CSPG4 Human Inquiry
IGFV-H268 Recombinant Human Anti-CD3 x Anti-CSPG4 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human CSPG4 Human Inquiry
IGFV-H237 Recombinant Human Anti-CD28 x Anti-CSPG4 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Human CSPG4 Human Inquiry
BSDB-H324 Recombinant Human Anti-FAS x Anti-CSPG4 Bispecific Antibody (Diabody) Human Diabody FAS Human CSPG4 Human Inquiry
BSDB-H268 Recombinant Human Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Diabody) Human Diabody CD3 Human CSPG4 Human Inquiry
BSDB-H237 Recombinant Human Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Diabody) Human Diabody CD28 Human CSPG4 Human Inquiry
BSFAB-H324 Recombinant Human Anti-FAS x Anti-CSPG4 Bispecific Antibody (Tandem Fab) Human Tandem Fab FAS Human CSPG4 Human Inquiry
BSFAB-H268 Recombinant Human Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human CSPG4 Human Inquiry
BSFAB-H237 Recombinant Human Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Human CSPG4 Human Inquiry
BSFV-H322 Recombinant Human Anti-FAS x Anti-CSPG4 Bispecific Antibody (Tandem scFv) Human Tandem scFv FAS Human CSPG4 Human Inquiry
BSFV-H268 Recombinant Human Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human CSPG4 Human Inquiry
BSFV-H237 Recombinant Human Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Human CSPG4 Human Inquiry
SCTB-067 Recombinant Anti-CSPG4 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse CSPG4 Mouse Inquiry
SCTB-035 Recombinant Anti-CSPG4 x Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Mouse CSPG4 Mouse Inquiry
SCDB-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody FAS Mouse CSPG4 Mouse Inquiry
SCDB-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse CSPG4 Mouse Inquiry
SCDB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Mouse CSPG4 Mouse Inquiry
FABIG-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Fab-IgG) Human Fab-IgG FAS Mouse CSPG4 Mouse Inquiry
FABIG-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse CSPG4 Mouse Inquiry
FABIG-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse CSPG4 Mouse Inquiry
TRIB-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv FAS Mouse CSPG4 Mouse Inquiry
TRIB-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse CSPG4 Mouse Inquiry
TRIB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse CSPG4 Mouse Inquiry
BSIG-159 Anti-FAS x Anti-CSPG4 Bispecific Antibody (IgG-IgG) Human IgG-IgG FAS Mouse CSPG4 Mouse Inquiry
BSIG-094 Anti-CD3 x Anti-CSPG4 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse CSPG4 Mouse Inquiry
BSIG-063 Anti-CD28 x Anti-CSPG4 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse CSPG4 Mouse Inquiry
CROSSAB-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (CrossMab) Human CrossMab FAS Mouse CSPG4 Mouse Inquiry
CROSSAB-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse CSPG4 Mouse Inquiry
CROSSAB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse CSPG4 Mouse Inquiry
IGFV-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (IgG-scFv) Human IgG-scFv FAS Mouse CSPG4 Mouse Inquiry
IGFV-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse CSPG4 Mouse Inquiry
IGFV-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse CSPG4 Mouse Inquiry
BSDB-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Diabody) Human Diabody FAS Mouse CSPG4 Mouse Inquiry
BSDB-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse CSPG4 Mouse Inquiry
BSDB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse CSPG4 Mouse Inquiry
BSFAB-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Tandem Fab) Human Tandem Fab FAS Mouse CSPG4 Mouse Inquiry
BSFAB-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse CSPG4 Mouse Inquiry
BSFAB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse CSPG4 Mouse Inquiry
BSFV-159 Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Tandem scFv) Human Tandem scFv FAS Mouse CSPG4 Mouse Inquiry
BSFV-094 Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse CSPG4 Mouse Inquiry
BSFV-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse CSPG4 Mouse Inquiry

Background

Chondroitin sulfate proteoglycan 4 (CSPG4) is a transmembrane protein that can be expressed on cells as an approximately 250 kDa N-linked glycoprotein or an ~ 450 kDa N-linked glycoprotein associated with proteoglycan components and plays a role in normal growth and development and disease. The functions of CSPG4 are mainly in the regulation of extracellular matrix (ECM) and cell signaling, although it also has regulatory effects on the immune system. CSPG4 plays a central role in intracellular and extracellular communication and in oncogenic pathways required for malignant tumor progression and metastasis. Scientists have explored CSPG4 in other malignant tumors such as melanoma as potential drug targets and markers. As a possible marker of malignancy in a range of tumors, CSPG4 has been used as a target for melanoma immunotherapy. CSPG4 is essential for melanoma growth by modulating integrin function and enhancing growth factor receptor regulatory pathways, including sustained activation of ERK1,2.

Fig.1 CSPG4 signalling pathways. (Chen, 2022) Fig.1 CSPG4 signalling pathways.1

Reference

  1. Chen, Kathryn, et al. "Chondroitin Sulfate Proteoglycan 4 as a Marker for Aggressive Squamous Cell Carcinoma." Cancers 14.22 (2022): 5564.
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