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CTLA4 & PD1 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H313 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CTLA4 Human PD1 Human Inquiry
T-BSDB-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CTLA4 Mouse PD1 Mouse Inquiry
SCIGG-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (scIgG) Human Single chain IgGs CTLA4 Human PD1 Human Inquiry
FABVC-397 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc CTLA4 Mouse PD1 llama Inquiry
BSSG-397 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (sdAb-IgG) Human sdAb-IgG CTLA4 Mouse PD1 llama Inquiry
HCAB-042 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb CTLA4 llama PD1 llama Inquiry
BIBD-397 Recombinant Anti-CTLA4 x Anti-PD1 VHH BispecificAntibody (Bibody) Human Bibody CTLA4 Mouse PD1 llama Inquiry
IGVHH-042 Recombinant Anti-CTLA4 x Anti-PD1 sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb CTLA4 Mouse PD1 llama Inquiry
BIVHH-042 Recombinant Anti-CTLA4 sdAb x Anti-PD1 sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb CTLA4 llama PD1 llama Inquiry
SCIGG-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (scIgG) Human Single chain IgGs CTLA4 Mouse PD1 Mouse Inquiry
FVTIG-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CTLA4 Human PD1 Human Inquiry
FVTIG-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CTLA4 Mouse PD1 Mouse Inquiry
BSSG-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (scFv-IgG) Human scFv-IgG CTLA4 Human PD1 Human Inquiry
BSSG-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (scFv-IgG) Human scFv-IgG CTLA4 Mouse PD1 Mouse Inquiry
IGLFV-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CTLA4 Human PD1 Human Inquiry
IGLFV-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CTLA4 Mouse PD1 Mouse Inquiry
BSGV-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (IgG-Fv) Human IgG-Fv CTLA4 Mouse PD1 Mouse Inquiry
BSGV-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (IgG-Fv) Human IgG-Fv CTLA4 Mouse PD1 Mouse Inquiry
BSDG-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Fv-IgG) Human Fv-IgG CTLA4 Human PD1 Human Inquiry
BSDG-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Fv-IgG) Human Fv-IgG CTLA4 Mouse PD1 Mouse Inquiry
BABFV-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CTLA4 Human PD1 Human Inquiry
BABFV-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CTLA4 Mouse PD1 Mouse Inquiry
FABVC-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CTLA4 Human PD1 Human Inquiry
FABVC-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CTLA4 Mouse PD1 Mouse Inquiry
SCDBC-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CTLA4 Human PD1 Human Inquiry
SCDBC-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CTLA4 Mouse PD1 Mouse Inquiry
BSDBC-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CTLA4 Human PD1 Human Inquiry
BSDBC-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CTLA4 Mouse PD1 Mouse Inquiry
SCDBF-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CTLA4 Human PD1 Human Inquiry
SCDBF-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CTLA4 Mouse PD1 Mouse Inquiry
BSFVF-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CTLA4 Human PD1 Human Inquiry
BSFVF-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CTLA4 Mouse PD1 Mouse Inquiry
BSDBF-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CTLA4 Human PD1 Human Inquiry
BSDBF-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CTLA4 Mouse PD1 Mouse Inquiry
BSTF-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CTLA4 Mouse PD1 Mouse Inquiry
BSTF-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CTLA4 Mouse PD1 Mouse Inquiry
BSCFV-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (scFv-Fc) Human scFv-Fc CTLA4 Mouse PD1 Mouse Inquiry
BSCFV-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (scFv-Fc) Human scFv-Fc CTLA4 Mouse PD1 Mouse Inquiry
MNAB-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Miniantibody) Human Miniantibody CTLA4 Mouse PD1 Mouse Inquiry
MNAB-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Miniantibody) Human Miniantibody CTLA4 Mouse PD1 Mouse Inquiry
BSFC-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CTLA4 Mouse PD1 Mouse Inquiry
BSFC-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CTLA4 Mouse PD1 Mouse Inquiry
BSCC-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CTLA4 Mouse PD1 Mouse Inquiry
BSCC-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CTLA4 Mouse PD1 Mouse Inquiry
BIBD-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Bibody) Human Bibody CTLA4 Mouse PD1 Mouse Inquiry
BIBD-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Bibody) Human Bibody CTLA4 Mouse PD1 Mouse Inquiry
FABFV-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Fab-Fv) Human Fab-Fv CTLA4 Human PD1 Human Inquiry
FABFV-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Fab-Fv) Human Fab-Fv CTLA4 Mouse PD1 Mouse Inquiry
MiniB-H315 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Bispecific Antibody (Minibody) Human Minibody CTLA4 Human PD1 Human Inquiry
MiniB-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Minibody) Human Minibody CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-SAR025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-SAR007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-NGB025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-NGB007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-MEL025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-MEL007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-BGN025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-BGN007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-ABR025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-ABR007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-PAP025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-PAP007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-SAP025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-SAP007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-RTA025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-RTA007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-GEL025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-GEL007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-PE025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-PE007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-DT025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFAB-DT007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFV-SAR025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFV-SAR007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFV-NGB025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFV-NGB007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFV-MEL025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFV-MEL007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFV-BGN025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFV-BGN007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFV-ABR025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
BSFV-ABR007 Recombinant Anti-CTLA4 x Anti-PD1 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse PD1 Mouse Inquiry
BSFV-PAP025 Recombinant Human Anti-CTLA4 x Human Anti-PD1 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human PD1 Human Inquiry
SCDB-H313 Recombinant Human Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CTLA4 Human PD1 Human Inquiry
FABIG-H313 Recombinant Human Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Fab-IgG) Human Fab-IgG CTLA4 Human PD1 Human Inquiry
TRIB-H315 Recombinant Human Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CTLA4 Human PD1 Human Inquiry
BSIG-H313 Human Anti-CTLA4 x Anti-PD1 Bispecific Antibody (IgG-IgG) Human IgG-IgG CTLA4 Human PD1 Human Inquiry
CROSSAB-H313 Recombinant Human Anti-CTLA4 x Anti-PD1 Bispecific Antibody (CrossMab) Human CrossMab CTLA4 Human PD1 Human Inquiry
IGFV-H313 Recombinant Human Anti-CTLA4 x Anti-PD1 Bispecific Antibody (IgG-scFv) Human IgG-scFv CTLA4 Human PD1 Human Inquiry
BSDB-H313 Recombinant Human Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Diabody) Human Diabody CTLA4 Human PD1 Human Inquiry
BSFAB-H313 Recombinant Human Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Tandem Fab) Human Tandem Fab CTLA4 Human PD1 Human Inquiry
BSFV-H313 Recombinant Human Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Tandem scFv) Human Tandem scFv CTLA4 Human PD1 Human Inquiry
SCDB-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CTLA4 Mouse PD1 Mouse Inquiry
FABIG-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Fab-IgG) Human Fab-IgG CTLA4 Mouse PD1 Mouse Inquiry
TRIB-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CTLA4 Mouse PD1 Mouse Inquiry
BSIG-146 Anti-CTLA4 x Anti-PD1 Bispecific Antibody (IgG-IgG) Human IgG-IgG CTLA4 Mouse PD1 Mouse Inquiry
CROSSAB-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (CrossMab) Human CrossMab CTLA4 Mouse PD1 Mouse Inquiry
IGFV-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (IgG-scFv) Human IgG-scFv CTLA4 Mouse PD1 Mouse Inquiry
BSDB-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Diabody) Human Diabody CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Tandem Fab) Human Tandem Fab CTLA4 Mouse PD1 Mouse Inquiry
BSFV-146 Recombinant Anti-CTLA4 x Anti-PD1 Bispecific Antibody (Tandem scFv) Human Tandem scFv CTLA4 Mouse PD1 Mouse Inquiry
BSFAB-DT024 Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human GLUT2 Human Inquiry
BSFAB-DT006 Recombinant Anti-CTLA4 x Anti-GLUT2 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse GLUT2 Mouse Inquiry
BSFV-SAR024 Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human GLUT2 Human Inquiry
BSFV-SAR006 Recombinant Anti-CTLA4 x Anti-GLUT2 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse GLUT2 Mouse Inquiry
BSFV-NGB024 Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human GLUT2 Human Inquiry
BSFV-NGB006 Recombinant Anti-CTLA4 x Anti-GLUT2 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse GLUT2 Mouse Inquiry
BSFV-MEL024 Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human GLUT2 Human Inquiry
BSFV-MEL006 Recombinant Anti-CTLA4 x Anti-GLUT2 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse GLUT2 Mouse Inquiry
BSFV-BGN024 Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human GLUT2 Human Inquiry
BSFV-BGN006 Recombinant Anti-CTLA4 x Anti-GLUT2 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse GLUT2 Mouse Inquiry
BSFV-ABR024 Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human GLUT2 Human Inquiry
BSFV-ABR006 Recombinant Anti-CTLA4 x Anti-GLUT2 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Mouse GLUT2 Mouse Inquiry
BSFV-PAP024 Recombinant Human Anti-CTLA4 x Human Anti-GLUT2 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin CTLA4 Human GLUT2 Human Inquiry
SCTB-H167 Recombinant Human Anti-PD1 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human PD1 Human Inquiry
SCDB-H346 Recombinant Human Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody PD1 Human TIM-3 Human Inquiry
SCDB-H312 Recombinant Human Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CTLA4 Human GLUT2 Human Inquiry
SCDB-H272 Recombinant Human Anti-CD3 x Anti-PD1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human PD1 Human Inquiry
FABIG-H346 Recombinant Human Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Fab-IgG) Human Fab-IgG PD1 Human TIM-3 Human Inquiry
FABIG-H312 Recombinant Human Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Fab-IgG) Human Fab-IgG CTLA4 Human GLUT2 Human Inquiry
FABIG-H272 Recombinant Human Anti-CD3 x Anti-PD1 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human PD1 Human Inquiry
TRIB-H348 Recombinant Human Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv PD1 Human TIM-3 Human Inquiry
TRIB-H314 Recombinant Human Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CTLA4 Human GLUT2 Human Inquiry
TRIB-H274 Recombinant Human Anti-CD3 x Anti-PD1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human PD1 Human Inquiry
BSIG-H346 Human Anti-PD1 x Anti-TIM-3 Bispecific Antibody (IgG-IgG) Human IgG-IgG PD1 Human TIM-3 Human Inquiry
BSIG-H312 Human Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CTLA4 Human GLUT2 Human Inquiry
BSIG-H272 Human Anti-CD3 x Anti-PD1 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human PD1 Human Inquiry
CROSSAB-H346 Recombinant Human Anti-PD1 x Anti-TIM-3 Bispecific Antibody (CrossMab) Human CrossMab PD1 Human TIM-3 Human Inquiry
CROSSAB-H312 Recombinant Human Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (CrossMab) Human CrossMab CTLA4 Human GLUT2 Human Inquiry
CROSSAB-H272 Recombinant Human Anti-CD3 x Anti-PD1 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human PD1 Human Inquiry
IGFV-H346 Recombinant Human Anti-PD1 x Anti-TIM-3 Bispecific Antibody (IgG-scFv) Human IgG-scFv PD1 Human TIM-3 Human Inquiry
IGFV-H312 Recombinant Human Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CTLA4 Human GLUT2 Human Inquiry
IGFV-H272 Recombinant Human Anti-CD3 x Anti-PD1 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human PD1 Human Inquiry
BSDB-H346 Recombinant Human Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Diabody) Human Diabody PD1 Human TIM-3 Human Inquiry
BSDB-H312 Recombinant Human Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Diabody) Human Diabody CTLA4 Human GLUT2 Human Inquiry
BSDB-H272 Recombinant Human Anti-CD3 x Anti-PD1 Bispecific Antibody (Diabody) Human Diabody CD3 Human PD1 Human Inquiry
BSFAB-H346 Recombinant Human Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Tandem Fab) Human Tandem Fab PD1 Human TIM-3 Human Inquiry
BSFAB-H312 Recombinant Human Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CTLA4 Human GLUT2 Human Inquiry
BSFAB-H272 Recombinant Human Anti-CD3 x Anti-PD1 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human PD1 Human Inquiry
BSFV-H345 Recombinant Human Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Tandem scFv) Human Tandem scFv PD1 Human TIM-3 Human Inquiry
BSFV-H312 Recombinant Human Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CTLA4 Human GLUT2 Human Inquiry
BSFV-H272 Recombinant Human Anti-CD3 x Anti-PD1 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human PD1 Human Inquiry
SCTB-071 Recombinant Anti-PD1 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse PD1 Mouse Inquiry
SCDB-185 Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody PD1 Mouse TIM-3 Mouse Inquiry
SCDB-145 Recombinant Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CTLA4 Mouse GLUT2 Mouse Inquiry
SCDB-098 Recombinant Anti-CD3 x Anti-PD1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse PD1 Mouse Inquiry
FABIG-185 Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Fab-IgG) Human Fab-IgG PD1 Mouse TIM-3 Mouse Inquiry
FABIG-145 Recombinant Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Fab-IgG) Human Fab-IgG CTLA4 Mouse GLUT2 Mouse Inquiry
FABIG-098 Recombinant Anti-CD3 x Anti-PD1 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse PD1 Mouse Inquiry
TRIB-185 Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv PD1 Mouse TIM-3 Mouse Inquiry
TRIB-145 Recombinant Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CTLA4 Mouse GLUT2 Mouse Inquiry
TRIB-098 Recombinant Anti-CD3 x Anti-PD1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse PD1 Mouse Inquiry
BSIG-185 Anti-PD1 x Anti-TIM-3 Bispecific Antibody (IgG-IgG) Human IgG-IgG PD1 Mouse TIM-3 Mouse Inquiry
BSIG-145 Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CTLA4 Mouse GLUT2 Mouse Inquiry
BSIG-098 Anti-CD3 x Anti-PD1 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse PD1 Mouse Inquiry
CROSSAB-185 Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (CrossMab) Human CrossMab PD1 Mouse TIM-3 Mouse Inquiry
CROSSAB-145 Recombinant Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (CrossMab) Human CrossMab CTLA4 Mouse GLUT2 Mouse Inquiry
CROSSAB-098 Recombinant Anti-CD3 x Anti-PD1 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse PD1 Mouse Inquiry
IGFV-185 Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (IgG-scFv) Human IgG-scFv PD1 Mouse TIM-3 Mouse Inquiry
IGFV-145 Recombinant Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CTLA4 Mouse GLUT2 Mouse Inquiry
IGFV-098 Recombinant Anti-CD3 x Anti-PD1 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse PD1 Mouse Inquiry
BSDB-185 Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Diabody) Human Diabody PD1 Mouse TIM-3 Mouse Inquiry
BSDB-145 Recombinant Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Diabody) Human Diabody CTLA4 Mouse GLUT2 Mouse Inquiry
BSDB-098 Recombinant Anti-CD3 x Anti-PD1 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse PD1 Mouse Inquiry
BSFV-185 Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Tandem scFv) Human Tandem scFv PD1 Mouse TIM-3 Mouse Inquiry
BSFAB-185 Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (Tandem Fab) Human Tandem Fab PD1 Mouse TIM-3 Mouse Inquiry
BSFAB-145 Recombinant Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CTLA4 Mouse GLUT2 Mouse Inquiry
BSFAB-098 Recombinant Anti-CD3 x Anti-PD1 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse PD1 Mouse Inquiry
BSFV-145 Recombinant Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CTLA4 Mouse GLUT2 Mouse Inquiry
BSFV-098 Recombinant Anti-CD3 x Anti-PD1 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse PD1 Mouse Inquiry

Background

CTLA-4 and PD-1 are inhibitors of T-cell immune function. CTLA-4 suppresses potentially autoreactive T cells in lymph nodes during the early phases of naive T-cell activation. PD-1 controls previously activated T cells in the final phases of an immune response, especially in peripheral tissues. Inhibiting these targets, which results in enhanced immune system activation, has resulted in novel immunotherapies for melanoma, non-small cell lung cancer, and other malignancies. As illustrated in Figure 1, CTLA-4 inhibition promotes the activation and proliferation of additional T-cell clones while decreasing Treg-mediated immunosuppression. The PD-1 pathway is blocked, which restores the activity of dormant antitumor T lymphocytes. A dual route inhibition might result in a greater and more persistent tumor immunity.

Fig.1 CTLA-4 and PD-1 dual pathway suppression of T cells may result in increased and longer-lasting tumor immunity. (Buchbinder,et al, 2016) Fig.1 CTLA-4 and PD-1 pathway blockade.1

Reference

  1. Buchbinder, Elizabeth I., and Anupam Desai. "CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition." American Journal of Clinical Oncology 39.1 (2016): 98.
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