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CXCR5 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H249 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human CXCR5 Human Inquiry
T-BSDB-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse CXCR5 Mouse Inquiry
SCIGG-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human CXCR5 Human Inquiry
SCIGG-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse CXCR5 Mouse Inquiry
FVTIG-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human CXCR5 Human Inquiry
FVTIG-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse CXCR5 Mouse Inquiry
BSSG-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human CXCR5 Human Inquiry
BSSG-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse CXCR5 Mouse Inquiry
IGLFV-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human CXCR5 Human Inquiry
IGLFV-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse CXCR5 Mouse Inquiry
BSGV-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse CXCR5 Mouse Inquiry
BSGV-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse CXCR5 Mouse Inquiry
BSDG-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human CXCR5 Human Inquiry
BSDG-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse CXCR5 Mouse Inquiry
BABFV-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human CXCR5 Human Inquiry
BABFV-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse CXCR5 Mouse Inquiry
FABVC-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human CXCR5 Human Inquiry
FABVC-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse CXCR5 Mouse Inquiry
SCDBC-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human CXCR5 Human Inquiry
SCDBC-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse CXCR5 Mouse Inquiry
BSDBC-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human CXCR5 Human Inquiry
BSDBC-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse CXCR5 Mouse Inquiry
SCDBF-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human CXCR5 Human Inquiry
SCDBF-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse CXCR5 Mouse Inquiry
BSFVF-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human CXCR5 Human Inquiry
BSFVF-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse CXCR5 Mouse Inquiry
BSDBF-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human CXCR5 Human Inquiry
BSDBF-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse CXCR5 Mouse Inquiry
BSTF-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse CXCR5 Mouse Inquiry
BSTF-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse CXCR5 Mouse Inquiry
BSCFV-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse CXCR5 Mouse Inquiry
BSCFV-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse CXCR5 Mouse Inquiry
MNAB-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse CXCR5 Mouse Inquiry
MNAB-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse CXCR5 Mouse Inquiry
BSFC-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse CXCR5 Mouse Inquiry
BSFC-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse CXCR5 Mouse Inquiry
BSCC-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse CXCR5 Mouse Inquiry
BSCC-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse CXCR5 Mouse Inquiry
BIBD-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse CXCR5 Mouse Inquiry
BIBD-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse CXCR5 Mouse Inquiry
FABFV-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human CXCR5 Human Inquiry
FABFV-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse CXCR5 Mouse Inquiry
MiniB-H251 Recombinant Human Anti-CD3 x Human Anti-CXCR5 Bispecific Antibody (Minibody) Human Minibody CD3 Human CXCR5 Human Inquiry
MiniB-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse CXCR5 Mouse Inquiry
SCTB-H146 Recombinant Human Anti-CXCR5 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human CXCR5 Human Inquiry
SCDB-H249 Recombinant Human Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human CXCR5 Human Inquiry
FABIG-H249 Recombinant Human Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human CXCR5 Human Inquiry
TRIB-H251 Recombinant Human Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human CXCR5 Human Inquiry
BSIG-H249 Human Anti-CD3 x Anti-CXCR5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human CXCR5 Human Inquiry
CROSSAB-H249 Recombinant Human Anti-CD3 x Anti-CXCR5 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human CXCR5 Human Inquiry
IGFV-H249 Recombinant Human Anti-CD3 x Anti-CXCR5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human CXCR5 Human Inquiry
BSDB-H249 Recombinant Human Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Diabody) Human Diabody CD3 Human CXCR5 Human Inquiry
BSFAB-H249 Recombinant Human Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human CXCR5 Human Inquiry
BSFV-H249 Recombinant Human Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human CXCR5 Human Inquiry
SCTB-048 Recombinant Anti-CXCR5 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse CXCR5 Mouse Inquiry
SCDB-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse CXCR5 Mouse Inquiry
FABIG-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse CXCR5 Mouse Inquiry
TRIB-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse CXCR5 Mouse Inquiry
BSIG-075 Anti-CD3 x Anti-CXCR5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse CXCR5 Mouse Inquiry
CROSSAB-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse CXCR5 Mouse Inquiry
IGFV-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse CXCR5 Mouse Inquiry
BSDB-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse CXCR5 Mouse Inquiry
BSFAB-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse CXCR5 Mouse Inquiry
BSFV-075 Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse CXCR5 Mouse Inquiry

Background

The chemokine C-X-C motif ligand 13 (CXCL13) is a B cell-attracting chemokine that interfaces with its receptor, CXCR5, to constitute a complex biological signaling network exerting pivotal functions under physiological conditions while also participating in the pathophysiology of inflammatory conditions, autoimmune disorders, neurological ailments, and neoplasms.

CXCL13 acts solely as a chemoattractant in coordination with CXCR5, but not other receptors. The prime functions credited to the CXCL13-CXCR5 interaction are:

  • Involvement in B cell differentiation and promotion of lymph follicle formation.
  • Enhancement of the production of natural antibodies and mucosal immunity.
  • Connecting inflammation and TLO, thus potentially modulating immune diseases.
  • Promotion of tumor initiation and pathological progression either through direct influence or by manipulating the immune environment.

CXCL13-CXCR5 axis. (Quintero, et al., 2022) Fig.1 CXCL13-CXCR5 axis.1

Reference

  1. Quintero, Wilson, et al. " CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer." Reviews on Cancer. 1877 (2022): 188799.
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