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DKK1 & SOST
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem Diabody) Human DKK1 SOST Inquiry
T-BSDB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem Diabody) Human DKK1 SOST Inquiry
SCIGG-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scIgG) Human Single chain IgGs DKK1 SOST Inquiry
SCIGG-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scIgG) Human Single chain IgGs DKK1 SOST Inquiry
FVTIG-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv4-Ig) Human Appended IgGs DKK1 SOST Inquiry
FVTIG-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv4-Ig) Human Appended IgGs DKK1 SOST Inquiry
BSSG-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv-IgG) Human Appended IgGs DKK1 SOST Inquiry
BSSG-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-IgG) Human Appended IgGs DKK1 SOST Inquiry
IGLFV-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs DKK1 SOST Inquiry
IGLFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs DKK1 SOST Inquiry
BSGV-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (IgG-Fv) Human IgG-Fv DKK1 SOST Inquiry
BSGV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG-Fv) Human IgG-Fv DKK1 SOST Inquiry
BSDG-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Fv-IgG) Human Appended IgGs DKK1 SOST Inquiry
BSDG-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fv-IgG) Human Appended IgGs DKK1 SOST Inquiry
BABFV-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins DKK1 SOST Inquiry
BABFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins DKK1 SOST Inquiry
FABVC-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins DKK1 SOST Inquiry
FABVC-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins DKK1 SOST Inquiry
SCDBC-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments DKK1 SOST Inquiry
SCDBC-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments DKK1 SOST Inquiry
BSDBC-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments DKK1 SOST Inquiry
BSDBC-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments DKK1 SOST Inquiry
SCDBF-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments DKK1 SOST Inquiry
SCDBF-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments DKK1 SOST Inquiry
BSFVF-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments DKK1 SOST Inquiry
BSFVF-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments DKK1 SOST Inquiry
BSDBF-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments DKK1 SOST Inquiry
BSDBF-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments DKK1 SOST Inquiry
BSTF-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments DKK1 SOST Inquiry
BSTF-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments DKK1 SOST Inquiry
BSCFV-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments DKK1 SOST Inquiry
BSCFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments DKK1 SOST Inquiry
MNAB-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments DKK1 SOST Inquiry
MNAB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments DKK1 SOST Inquiry
BSFC-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments DKK1 SOST Inquiry
BSFC-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments DKK1 SOST Inquiry
BSCC-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments DKK1 SOST Inquiry
BSCC-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments DKK1 SOST Inquiry
BIBD-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Bibody) Human Bibody DKK1 SOST Inquiry
BIBD-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Bibody) Human Bibody DKK1 SOST Inquiry
FABFV-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Fab-Fv) Human Fab-Fv DKK1 SOST Inquiry
FABFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-Fv) Human Fab-Fv DKK1 SOST Inquiry
MiniB-H317 Recombinant Human Anti-DKK1 x Human Anti-SOST Bispecific Antibody (Minibody) Human Minibody DKK1 SOST Inquiry
MiniB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Minibody) Human Minibody DKK1 SOST Inquiry
SCDB-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DKK1 SOST Inquiry
FABIG-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-IgG) Human Fab-IgG DKK1 SOST Inquiry
TRIB-H317 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Triple Body) Human Triple Body DKK1 SOST Inquiry
BSIG-H315 Human Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG-IgG) Human IgG-IgG DKK1 SOST Inquiry
CROSSAB-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (CrossMab) Human CrossMab DKK1 SOST Inquiry
IGFV-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG-scFv) Human IgG-scFv DKK1 SOST Inquiry
BSDB-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Diabody) Human Diabody DKK1 SOST Inquiry
BSFAB-H315 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem Fab) Human Tandem Fab DKK1 SOST Inquiry
BSFV-H314 Recombinant Human Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem scFv) Human Tandem scFv DKK1 SOST Inquiry
SCDB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DKK1 SOST Inquiry
FABIG-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Fab-IgG) Human Fab-IgG DKK1 SOST Inquiry
TRIB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Triple Body) Human Triple Body DKK1 SOST Inquiry
BSIG-148 Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG-IgG) Human IgG-IgG DKK1 SOST Inquiry
CROSSAB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (CrossMab) Human CrossMab DKK1 SOST Inquiry
IGFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (IgG-scFv) Human IgG-scFv DKK1 SOST Inquiry
BSDB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Diabody) Human Diabody DKK1 SOST Inquiry
BSFAB-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem Fab) Human Tandem Fab DKK1 SOST Inquiry
BSFV-148 Recombinant Anti-DKK1 x Anti-SOST Bispecific Antibody (Tandem scFv) Human Tandem scFv DKK1 SOST Inquiry

Background

DKK1 (Dickkopf Wnt signaling pathway inhibitor 1), also known as dickkopf-related protein 1, dickkopf-1 or SK, is an approximately 29 kDa soluble protein released in the bone microenvironment and detected in the circulation. It has 266 amino acids encoded by the DKK1 gene mapping at the chromosome 10q21.1. DKK1 belongs to the dickkopf family of proteins, featured by two cysteine-rich domains that mediate proteins interactions. It is a key regulator of osteoblast activity and osteoblastic bone metastasis, and may dually rely on the downregulation of its secretion from osteoblasts by tumor-produced ET-1 and prostate cancer cells. Furthermore, DKK-1 functions as a direct inhibitor of the Wnt/β-catenin signal pathway by binding Kremen and LRP5/LRP6 proteins with high affinity. Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
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