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DLL3 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0124-N1 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Tandem scFv-scFc) (BsIgG) Human BsIgG CD3 Human DLL3 Human Inquiry
T-BSDB-H250 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human DLL3 Human Inquiry
T-BSDB-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse DLL3 Mouse Inquiry
SCIGG-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human DLL3 Human Inquiry
SCIGG-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse DLL3 Mouse Inquiry
FVTIG-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human DLL3 Human Inquiry
FVTIG-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse DLL3 Mouse Inquiry
BSSG-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human DLL3 Human Inquiry
BSSG-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse DLL3 Mouse Inquiry
IGLFV-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human DLL3 Human Inquiry
IGLFV-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse DLL3 Mouse Inquiry
BSGV-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse DLL3 Mouse Inquiry
BSGV-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse DLL3 Mouse Inquiry
BSDG-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human DLL3 Human Inquiry
BSDG-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse DLL3 Mouse Inquiry
BABFV-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human DLL3 Human Inquiry
BABFV-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse DLL3 Mouse Inquiry
FABVC-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human DLL3 Human Inquiry
FABVC-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse DLL3 Mouse Inquiry
SCDBC-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human DLL3 Human Inquiry
SCDBC-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse DLL3 Mouse Inquiry
BSDBC-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human DLL3 Human Inquiry
BSDBC-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse DLL3 Mouse Inquiry
SCDBF-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human DLL3 Human Inquiry
SCDBF-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse DLL3 Mouse Inquiry
BSFVF-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human DLL3 Human Inquiry
BSFVF-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse DLL3 Mouse Inquiry
BSDBF-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human DLL3 Human Inquiry
BSDBF-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse DLL3 Mouse Inquiry
BSTF-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse DLL3 Mouse Inquiry
BSTF-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse DLL3 Mouse Inquiry
BSCFV-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse DLL3 Mouse Inquiry
BSCFV-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse DLL3 Mouse Inquiry
MNAB-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse DLL3 Mouse Inquiry
MNAB-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse DLL3 Mouse Inquiry
BSFC-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse DLL3 Mouse Inquiry
BSFC-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse DLL3 Mouse Inquiry
BSCC-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse DLL3 Mouse Inquiry
BSCC-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse DLL3 Mouse Inquiry
BIBD-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse DLL3 Mouse Inquiry
BIBD-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse DLL3 Mouse Inquiry
FABFV-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human DLL3 Human Inquiry
FABFV-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse DLL3 Mouse Inquiry
MiniB-H252 Recombinant Human Anti-CD3 x Human Anti-DLL3 Bispecific Antibody (Minibody) Human Minibody CD3 Human DLL3 Human Inquiry
MiniB-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse DLL3 Mouse Inquiry
SCTB-H147 Recombinant Human Anti-DLL3 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human DLL3 Human Inquiry
SCDB-H250 Recombinant Human Anti-CD3 x Anti-DLL3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human DLL3 Human Inquiry
FABIG-H250 Recombinant Human Anti-CD3 x Anti-DLL3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human DLL3 Human Inquiry
TRIB-H252 Recombinant Human Anti-CD3 x Anti-DLL3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human DLL3 Human Inquiry
BSIG-H250 Human Anti-CD3 x Anti-DLL3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human DLL3 Human Inquiry
CROSSAB-H250 Recombinant Human Anti-CD3 x Anti-DLL3 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human DLL3 Human Inquiry
IGFV-H250 Recombinant Human Anti-CD3 x Anti-DLL3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human DLL3 Human Inquiry
BSDB-H250 Recombinant Human Anti-CD3 x Anti-DLL3 Bispecific Antibody (Diabody) Human Diabody CD3 Human DLL3 Human Inquiry
BSFAB-H250 Recombinant Human Anti-CD3 x Anti-DLL3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human DLL3 Human Inquiry
BSFV-H250 Recombinant Human Anti-CD3 x Anti-DLL3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human DLL3 Human Inquiry
SCTB-049 Recombinant Anti-DLL3 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse DLL3 Mouse Inquiry
SCDB-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse DLL3 Mouse Inquiry
FABIG-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse DLL3 Mouse Inquiry
TRIB-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse DLL3 Mouse Inquiry
BSIG-076 Anti-CD3 x Anti-DLL3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse DLL3 Mouse Inquiry
CROSSAB-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse DLL3 Mouse Inquiry
IGFV-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse DLL3 Mouse Inquiry
BSDB-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse DLL3 Mouse Inquiry
BSFAB-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse DLL3 Mouse Inquiry
BSFV-076 Recombinant Anti-CD3 x Anti-DLL3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse DLL3 Mouse Inquiry

Background

Delta-like ligand 3 (DLL3) is a restrictive Notch ligand that demonstrates significant overexpression within neuroendocrine tumors, with its cytoplasmic manifestation found exclusively in a minimal quantity of healthy cells, such as neurons, pituitary cells, or islet cells.

The expression of DLL3 is generally regulated by transcription factor ASCL1, an imperative factor required for lung neuroendocrine cell development but also serves as a catalyst to tumorigenic progression and has been clinically observed to possess a certain correlation with tumor advancement.

DLL3 functions in inhibiting and downregulating Notch signaling pathway during the growth of neuroendocrine tumors, and promotes the migration and invasiveness of high-grade lung neuroendocrine carcinomas via control mechanisms involving Snail, the epithelial-mesenchymal transition regulatory protein.

DLL3 in cancer and targeted investigation protocols. (Owen, et al., 2019) Fig.1 DLL3 in cancer and targeted investigation protocols.1

Reference

  1. Owen, Giffin, et al. " DLL3: an emerging target in small cell lung cancer." Journal of Hematology and Oncology. 12 (2019): 61.
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