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DLL4 & VEGF Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H316 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DLL4 Human VEGF Human Inquiry
T-BSDB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DLL4 Mouse VEGF Mouse Inquiry
SCIGG-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scIgG) Human Single chain IgGs DLL4 Human VEGF Human Inquiry
SCIGG-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scIgG) Human Single chain IgGs DLL4 Mouse VEGF Mouse Inquiry
FVTIG-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DLL4 Human VEGF Human Inquiry
FVTIG-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DLL4 Mouse VEGF Mouse Inquiry
BSSG-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv-IgG) Human scFv-IgG DLL4 Human VEGF Human Inquiry
BSSG-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-IgG) Human scFv-IgG DLL4 Mouse VEGF Mouse Inquiry
IGLFV-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DLL4 Human VEGF Human Inquiry
IGLFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DLL4 Mouse VEGF Mouse Inquiry
BSGV-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (IgG-Fv) Human IgG-Fv DLL4 Mouse VEGF Mouse Inquiry
BSGV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG-Fv) Human IgG-Fv DLL4 Mouse VEGF Mouse Inquiry
BSDG-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Fv-IgG) Human Fv-IgG DLL4 Human VEGF Human Inquiry
BSDG-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fv-IgG) Human Fv-IgG DLL4 Mouse VEGF Mouse Inquiry
BABFV-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DLL4 Human VEGF Human Inquiry
BABFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DLL4 Mouse VEGF Mouse Inquiry
FABVC-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DLL4 Human VEGF Human Inquiry
FABVC-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DLL4 Mouse VEGF Mouse Inquiry
SCDBC-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DLL4 Human VEGF Human Inquiry
SCDBC-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DLL4 Mouse VEGF Mouse Inquiry
BSDBC-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DLL4 Human VEGF Human Inquiry
BSDBC-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DLL4 Mouse VEGF Mouse Inquiry
SCDBF-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DLL4 Human VEGF Human Inquiry
SCDBF-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DLL4 Mouse VEGF Mouse Inquiry
BSFVF-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DLL4 Human VEGF Human Inquiry
BSFVF-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DLL4 Mouse VEGF Mouse Inquiry
BSDBF-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DLL4 Human VEGF Human Inquiry
BSDBF-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DLL4 Mouse VEGF Mouse Inquiry
BSTF-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DLL4 Mouse VEGF Mouse Inquiry
BSTF-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DLL4 Mouse VEGF Mouse Inquiry
BSCFV-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv-Fc) Human scFv-Fc DLL4 Mouse VEGF Mouse Inquiry
BSCFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-Fc) Human scFv-Fc DLL4 Mouse VEGF Mouse Inquiry
MNAB-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Miniantibody) Human Miniantibody DLL4 Mouse VEGF Mouse Inquiry
MNAB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Miniantibody) Human Miniantibody DLL4 Mouse VEGF Mouse Inquiry
BSFC-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv-CH3) Human scFv-CH3 DLL4 Mouse VEGF Mouse Inquiry
BSFC-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-CH3) Human scFv-CH3 DLL4 Mouse VEGF Mouse Inquiry
BSCC-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DLL4 Mouse VEGF Mouse Inquiry
BSCC-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DLL4 Mouse VEGF Mouse Inquiry
BIBD-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Bibody) Human Bibody DLL4 Mouse VEGF Mouse Inquiry
BIBD-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Bibody) Human Bibody DLL4 Mouse VEGF Mouse Inquiry
FABFV-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Fab-Fv) Human Fab-Fv DLL4 Human VEGF Human Inquiry
FABFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-Fv) Human Fab-Fv DLL4 Mouse VEGF Mouse Inquiry
MiniB-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Minibody) Human Minibody DLL4 Human VEGF Human Inquiry
MiniB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Minibody) Human Minibody DLL4 Mouse VEGF Mouse Inquiry
SCDB-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DLL4 Human VEGF Human Inquiry
FABIG-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG DLL4 Human VEGF Human Inquiry
TRIB-H318 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DLL4 Human VEGF Human Inquiry
BSIG-H316 Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG DLL4 Human VEGF Human Inquiry
CROSSAB-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab DLL4 Human VEGF Human Inquiry
IGFV-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv DLL4 Human VEGF Human Inquiry
BSDB-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody DLL4 Human VEGF Human Inquiry
BSFAB-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab DLL4 Human VEGF Human Inquiry
BSFV-H315 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv DLL4 Human VEGF Human Inquiry
SCDB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DLL4 Mouse VEGF Mouse Inquiry
FABIG-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG DLL4 Mouse VEGF Mouse Inquiry
TRIB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DLL4 Mouse VEGF Mouse Inquiry
BSIG-149 Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG DLL4 Mouse VEGF Mouse Inquiry
CROSSAB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab DLL4 Mouse VEGF Mouse Inquiry
IGFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv DLL4 Mouse VEGF Mouse Inquiry
BSDB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody DLL4 Mouse VEGF Mouse Inquiry
BSFAB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab DLL4 Mouse VEGF Mouse Inquiry
BSFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv DLL4 Mouse VEGF Mouse Inquiry
FABIG-H349 Recombinant Human Anti-VEGFB x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG VEGFB Human VEGF Human Inquiry
FABIG-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG PDGFR1 Human VEGF Human Inquiry
FABIG-H345 Recombinant Human Anti-OPN x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG OPN Human VEGF Human Inquiry
FABIG-H332 Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Human VEGF Human Inquiry
FABIG-H325 Recombinant Human Anti-FGF2 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG FGF2 Human VEGF Human Inquiry
TRIB-H351 Recombinant Human Anti-VEGFB x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv VEGFB Human VEGF Human Inquiry
TRIB-H349 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv PDGFR1 Human VEGF Human Inquiry
TRIB-H347 Recombinant Human Anti-OPN x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv OPN Human VEGF Human Inquiry
TRIB-H334 Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Human VEGF Human Inquiry
TRIB-H327 Recombinant Human Anti-FGF2 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv FGF2 Human VEGF Human Inquiry
BSIG-H349 Human Anti-VEGFB x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG VEGFB Human VEGF Human Inquiry
BSIG-H347 Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG PDGFR1 Human VEGF Human Inquiry
BSIG-H345 Human Anti-OPN x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG OPN Human VEGF Human Inquiry
BSIG-H332 Human Anti-HER2 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Human VEGF Human Inquiry
BSIG-H325 Human Anti-FGF2 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG FGF2 Human VEGF Human Inquiry
CROSSAB-H349 Recombinant Human Anti-VEGFB x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab VEGFB Human VEGF Human Inquiry
CROSSAB-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab PDGFR1 Human VEGF Human Inquiry
CROSSAB-H345 Recombinant Human Anti-OPN x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab OPN Human VEGF Human Inquiry
CROSSAB-H332 Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab HER2 Human VEGF Human Inquiry
CROSSAB-H325 Recombinant Human Anti-FGF2 x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab FGF2 Human VEGF Human Inquiry
IGFV-H349 Recombinant Human Anti-VEGFB x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv VEGFB Human VEGF Human Inquiry
IGFV-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv PDGFR1 Human VEGF Human Inquiry
IGFV-H345 Recombinant Human Anti-OPN x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv OPN Human VEGF Human Inquiry
IGFV-H332 Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Human VEGF Human Inquiry
IGFV-H325 Recombinant Human Anti-FGF2 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv FGF2 Human VEGF Human Inquiry
BSDB-H349 Recombinant Human Anti-VEGFB x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody VEGFB Human VEGF Human Inquiry
BSDB-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody PDGFR1 Human VEGF Human Inquiry
BSDB-H345 Recombinant Human Anti-OPN x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody OPN Human VEGF Human Inquiry
BSDB-H332 Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody HER2 Human VEGF Human Inquiry
BSDB-H325 Recombinant Human Anti-FGF2 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody FGF2 Human VEGF Human Inquiry
BSFAB-H349 Recombinant Human Anti-VEGFB x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab VEGFB Human VEGF Human Inquiry
BSFAB-H347 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab PDGFR1 Human VEGF Human Inquiry
BSFAB-H345 Recombinant Human Anti-OPN x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab OPN Human VEGF Human Inquiry
BSFAB-H332 Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Human VEGF Human Inquiry
BSFAB-H325 Recombinant Human Anti-FGF2 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab FGF2 Human VEGF Human Inquiry
BSFV-H349 Recombinant Human Anti-VEGFB x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv VEGFB Human VEGF Human Inquiry
BSFV-H346 Recombinant Human Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv PDGFR1 Human VEGF Human Inquiry
BSFV-H344 Recombinant Human Anti-OPN x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv OPN Human VEGF Human Inquiry
BSFV-H330 Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Human VEGF Human Inquiry
BSFV-H323 Recombinant Human Anti-FGF2 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv FGF2 Human VEGF Human Inquiry
SCDB-190 Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody VEGFB Mouse VEGF Mouse Inquiry
SCDB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody PDGFR1 Mouse VEGF Mouse Inquiry
SCDB-183 Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody OPN Mouse VEGF Mouse Inquiry
SCDB-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER2 Mouse VEGF Mouse Inquiry
SCDB-160 Recombinant Anti-FGF2 x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody FGF2 Mouse VEGF Mouse Inquiry
FABIG-190 Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG VEGFB Mouse VEGF Mouse Inquiry
FABIG-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG PDGFR1 Mouse VEGF Mouse Inquiry
FABIG-183 Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG OPN Mouse VEGF Mouse Inquiry
FABIG-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Mouse VEGF Mouse Inquiry
FABIG-160 Recombinant Anti-FGF2 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG FGF2 Mouse VEGF Mouse Inquiry
TRIB-190 Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv VEGFB Mouse VEGF Mouse Inquiry
TRIB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv PDGFR1 Mouse VEGF Mouse Inquiry
TRIB-183 Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv OPN Mouse VEGF Mouse Inquiry
TRIB-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Mouse VEGF Mouse Inquiry
TRIB-160 Recombinant Anti-FGF2 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv FGF2 Mouse VEGF Mouse Inquiry
BSIG-190 Anti-VEGFB x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG VEGFB Mouse VEGF Mouse Inquiry
BSIG-186 Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG PDGFR1 Mouse VEGF Mouse Inquiry
BSIG-183 Anti-OPN x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG OPN Mouse VEGF Mouse Inquiry
BSIG-168 Anti-HER2 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Mouse VEGF Mouse Inquiry
BSIG-160 Anti-FGF2 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG FGF2 Mouse VEGF Mouse Inquiry
CROSSAB-190 Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab VEGFB Mouse VEGF Mouse Inquiry
CROSSAB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab PDGFR1 Mouse VEGF Mouse Inquiry
CROSSAB-183 Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab OPN Mouse VEGF Mouse Inquiry
IGFV-190 Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv VEGFB Mouse VEGF Mouse Inquiry
IGFV-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv PDGFR1 Mouse VEGF Mouse Inquiry
IGFV-183 Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv OPN Mouse VEGF Mouse Inquiry
IGFV-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Mouse VEGF Mouse Inquiry
IGFV-160 Recombinant Anti-FGF2 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv FGF2 Mouse VEGF Mouse Inquiry
BSDB-190 Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody VEGFB Mouse VEGF Mouse Inquiry
BSDB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody PDGFR1 Mouse VEGF Mouse Inquiry
BSDB-183 Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody OPN Mouse VEGF Mouse Inquiry
BSDB-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody HER2 Mouse VEGF Mouse Inquiry
BSDB-160 Recombinant Anti-FGF2 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody FGF2 Mouse VEGF Mouse Inquiry
BSFV-183 Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv OPN Mouse VEGF Mouse Inquiry
BSFAB-190 Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab VEGFB Mouse VEGF Mouse Inquiry
BSFAB-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab PDGFR1 Mouse VEGF Mouse Inquiry
BSFAB-183 Recombinant Anti-OPN x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab OPN Mouse VEGF Mouse Inquiry
BSFAB-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Mouse VEGF Mouse Inquiry
BSFAB-160 Recombinant Anti-FGF2 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab FGF2 Mouse VEGF Mouse Inquiry
BSFV-190 Recombinant Anti-VEGFB x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv VEGFB Mouse VEGF Mouse Inquiry
BSFV-186 Recombinant Anti-PDGFR1 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv PDGFR1 Mouse VEGF Mouse Inquiry
BSFV-168 Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Mouse VEGF Mouse Inquiry
BSFV-160 Recombinant Anti-FGF2 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv FGF2 Mouse VEGF Mouse Inquiry

Background

Delta-like-ligand 4 (DLL4) holds promise as a valuable target for enhancing the effects of VEGF inhibitors in cancer treatment. When both the VEGF/VEGFR and DLL4/Notch signaling pathways are simultaneously blocked, there is a synergistic anti-angiogenic effect, resulting in more potent anti-cancer effects in xenograft models. The VEFG signaling system is essential for the regression of tumor vasculature, and blocking the VEFG/VEGFR pathway prevents tumor angiogenesis that is accelerated by VEGF. In contrast, blocking DLL4/Notch slows tumor growth by increasing vascular density and decreasing functional tumor vasculature via endothelial cell hyperproliferation. Bispecific antibodies (BsAbs) that target both DLL4 and VEGF demonstrate greater potency compared to monoclonal antibodies that solely target DLL4 or VEGF. Thus, the strategic targeting of DLL4 and VEGF offers significant advantages for the development of cancer therapies.

Fig. 1 Dual tumor-targeting BsAbs modulate two pathways in the TME. (You, et al., 2021) Fig. 1 Dual tumor-targeting BsAbs in immuno-oncology.1

Reference

  1. You, Gihoon et al. "Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies." Vaccines 9.7 (2021): 724.
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