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DLL4 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H316 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DLL4 Human VEGF Human Inquiry
T-BSDB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DLL4 Mouse VEGF Mouse Inquiry
SCIGG-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scIgG) Human Single chain IgGs DLL4 Human VEGF Human Inquiry
SCIGG-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scIgG) Human Single chain IgGs DLL4 Mouse VEGF Mouse Inquiry
FVTIG-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DLL4 Human VEGF Human Inquiry
FVTIG-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DLL4 Mouse VEGF Mouse Inquiry
BSSG-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv-IgG) Human scFv-IgG DLL4 Human VEGF Human Inquiry
BSSG-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-IgG) Human scFv-IgG DLL4 Mouse VEGF Mouse Inquiry
IGLFV-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DLL4 Human VEGF Human Inquiry
IGLFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DLL4 Mouse VEGF Mouse Inquiry
BSGV-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (IgG-Fv) Human IgG-Fv DLL4 Human VEGF Human Inquiry
BSGV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG-Fv) Human IgG-Fv DLL4 Mouse VEGF Mouse Inquiry
BSDG-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Fv-IgG) Human Fv-IgG DLL4 Human VEGF Human Inquiry
BSDG-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fv-IgG) Human Fv-IgG DLL4 Mouse VEGF Mouse Inquiry
BABFV-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DLL4 Human VEGF Human Inquiry
BABFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DLL4 Mouse VEGF Mouse Inquiry
FABVC-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DLL4 Human VEGF Human Inquiry
FABVC-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DLL4 Mouse VEGF Mouse Inquiry
SCDBC-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DLL4 Human VEGF Human Inquiry
SCDBC-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DLL4 Mouse VEGF Mouse Inquiry
BSDBC-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DLL4 Human VEGF Human Inquiry
BSDBC-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DLL4 Mouse VEGF Mouse Inquiry
SCDBF-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DLL4 Human VEGF Human Inquiry
SCDBF-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DLL4 Mouse VEGF Mouse Inquiry
BSFVF-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DLL4 Human VEGF Human Inquiry
BSFVF-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DLL4 Mouse VEGF Mouse Inquiry
BSDBF-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DLL4 Human VEGF Human Inquiry
BSDBF-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DLL4 Mouse VEGF Mouse Inquiry
BSTF-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DLL4 Human VEGF Human Inquiry
BSTF-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DLL4 Mouse VEGF Mouse Inquiry
BSCFV-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv-Fc) Human scFv-Fc DLL4 Human VEGF Human Inquiry
BSCFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-Fc) Human scFv-Fc DLL4 Mouse VEGF Mouse Inquiry
MNAB-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Miniantibody) Human Miniantibody DLL4 Human VEGF Human Inquiry
MNAB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Miniantibody) Human Miniantibody DLL4 Mouse VEGF Mouse Inquiry
BSFC-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv-CH3) Human scFv-CH3 DLL4 Human VEGF Human Inquiry
BSFC-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-CH3) Human scFv-CH3 DLL4 Mouse VEGF Mouse Inquiry
BSCC-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DLL4 Human VEGF Human Inquiry
BSCC-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DLL4 Mouse VEGF Mouse Inquiry
BIBD-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Bibody) Human Bibody DLL4 Human VEGF Human Inquiry
BIBD-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Bibody) Human Bibody DLL4 Mouse VEGF Mouse Inquiry
FABFV-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Fab-Fv) Human Fab-Fv DLL4 Human VEGF Human Inquiry
FABFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-Fv) Human Fab-Fv DLL4 Mouse VEGF Mouse Inquiry
MiniB-H318 Recombinant Human Anti-DLL4 x Human Anti-VEGF Bispecific Antibody (Minibody) Human Minibody DLL4 Human VEGF Human Inquiry
MiniB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Minibody) Human Minibody DLL4 Mouse VEGF Mouse Inquiry
SCDB-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DLL4 Human VEGF Human Inquiry
FABIG-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG DLL4 Human VEGF Human Inquiry
TRIB-H318 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DLL4 Human VEGF Human Inquiry
BSIG-H316 Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG DLL4 Human VEGF Human Inquiry
CROSSAB-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab DLL4 Human VEGF Human Inquiry
IGFV-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv DLL4 Human VEGF Human Inquiry
BSDB-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody DLL4 Human VEGF Human Inquiry
BSFAB-H316 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab DLL4 Human VEGF Human Inquiry
BSFV-H315 Recombinant Human Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv DLL4 Human VEGF Human Inquiry
SCDB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DLL4 Mouse VEGF Mouse Inquiry
FABIG-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-IgG) Human Fab-IgG DLL4 Mouse VEGF Mouse Inquiry
TRIB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DLL4 Mouse VEGF Mouse Inquiry
BSIG-149 Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG-IgG) Human IgG-IgG DLL4 Mouse VEGF Mouse Inquiry
CROSSAB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (CrossMab) Human CrossMab DLL4 Mouse VEGF Mouse Inquiry
IGFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (IgG-scFv) Human IgG-scFv DLL4 Mouse VEGF Mouse Inquiry
BSDB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Diabody) Human Diabody DLL4 Mouse VEGF Mouse Inquiry
BSFAB-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem Fab) Human Tandem Fab DLL4 Mouse VEGF Mouse Inquiry
BSFV-149 Recombinant Anti-DLL4 x Anti-VEGF Bispecific Antibody (Tandem scFv) Human Tandem scFv DLL4 Mouse VEGF Mouse Inquiry

Background

Delta-like protein 4 (DLL4), is encoded by the DLL4 gene in humans, also known as AOS6 or hdelta2. This protein plays a critical role as a Notch ligand essential for vascular development. The predicted protein sequences of DLL4 exhibit characteristic features of the Delta family of Notch ligands. DLL4 is associated with angiogenesis, which activates NOTCH1 and NOTCH4. DLL4 exerts a negative modulatory effect on endothelial cell angiogenic sprouting, proliferation, and migration. DLL4 exhibits enhanced NOTCH signaling activation in T Cells, directing Th1 and Th17 differentiation. What's more, DLL4 expression has been identified in cervical cancer, and plays a crucial role in retinal progenitor proliferation.

Role of DLL4+ dendritic cells as critical regulators in effector T cell responses via Notch signaling. (Meng, et al., 2016) Fig.1 Role of DLL4+ dendritic cells as critical regulators in effector T cell responses via Notch signaling.1

Reference

  1. Meng, Lijun, et al. "DLL4+ dendritic cells: key regulators of Notch Signaling in effector T cell responses." Pharmacological research 113 (2016): 449-457.
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