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DR5 & FAP Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H318 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DR5 Human FAP Human Inquiry
T-BSDB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DR5 Mouse FAP Mouse Inquiry
SCIGG-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scIgG) Human Single chain IgGs DR5 Human FAP Human Inquiry
SCIGG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scIgG) Human Single chain IgGs DR5 Mouse FAP Mouse Inquiry
FVTIG-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DR5 Human FAP Human Inquiry
FVTIG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DR5 Mouse FAP Mouse Inquiry
BSSG-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-IgG) Human scFv-IgG DR5 Human FAP Human Inquiry
BSSG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-IgG) Human scFv-IgG DR5 Mouse FAP Mouse Inquiry
IGLFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DR5 Human FAP Human Inquiry
IGLFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DR5 Mouse FAP Mouse Inquiry
BSGV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (IgG-Fv) Human IgG-Fv DR5 Mouse FAP Mouse Inquiry
BSGV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-Fv) Human IgG-Fv DR5 Mouse FAP Mouse Inquiry
BSDG-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fv-IgG) Human Fv-IgG DR5 Human FAP Human Inquiry
BSDG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fv-IgG) Human Fv-IgG DR5 Mouse FAP Mouse Inquiry
BABFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DR5 Human FAP Human Inquiry
BABFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DR5 Mouse FAP Mouse Inquiry
FABVC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DR5 Human FAP Human Inquiry
FABVC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DR5 Mouse FAP Mouse Inquiry
SCDBC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DR5 Human FAP Human Inquiry
SCDBC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DR5 Mouse FAP Mouse Inquiry
BSDBC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DR5 Human FAP Human Inquiry
BSDBC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DR5 Mouse FAP Mouse Inquiry
SCDBF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DR5 Human FAP Human Inquiry
SCDBF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DR5 Mouse FAP Mouse Inquiry
BSFVF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DR5 Human FAP Human Inquiry
BSFVF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DR5 Mouse FAP Mouse Inquiry
BSDBF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DR5 Human FAP Human Inquiry
BSDBF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DR5 Mouse FAP Mouse Inquiry
BSTF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DR5 Mouse FAP Mouse Inquiry
BSTF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DR5 Mouse FAP Mouse Inquiry
BSCFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-Fc DR5 Mouse FAP Mouse Inquiry
BSCFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-Fc DR5 Mouse FAP Mouse Inquiry
MNAB-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Miniantibody) Human Miniantibody DR5 Mouse FAP Mouse Inquiry
MNAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Miniantibody) Human Miniantibody DR5 Mouse FAP Mouse Inquiry
BSFC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 DR5 Mouse FAP Mouse Inquiry
BSFC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 DR5 Mouse FAP Mouse Inquiry
BSCC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DR5 Mouse FAP Mouse Inquiry
BSCC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DR5 Mouse FAP Mouse Inquiry
BIBD-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Bibody) Human Bibody DR5 Mouse FAP Mouse Inquiry
BIBD-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Bibody) Human Bibody DR5 Mouse FAP Mouse Inquiry
FABFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv DR5 Human FAP Human Inquiry
FABFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv DR5 Mouse FAP Mouse Inquiry
MiniB-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Minibody) Human Minibody DR5 Human FAP Human Inquiry
MiniB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Minibody) Human Minibody DR5 Mouse FAP Mouse Inquiry
SCDB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DR5 Human FAP Human Inquiry
FABIG-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG DR5 Human FAP Human Inquiry
TRIB-H320 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DR5 Human FAP Human Inquiry
BSIG-H318 Human Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG DR5 Human FAP Human Inquiry
CROSSAB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab DR5 Human FAP Human Inquiry
IGFV-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv DR5 Human FAP Human Inquiry
BSDB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody DR5 Human FAP Human Inquiry
BSFAB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab DR5 Human FAP Human Inquiry
BSFV-H317 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv DR5 Human FAP Human Inquiry
SCDB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DR5 Mouse FAP Mouse Inquiry
FABIG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG DR5 Mouse FAP Mouse Inquiry
TRIB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DR5 Mouse FAP Mouse Inquiry
BSIG-152 Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG DR5 Mouse FAP Mouse Inquiry
CROSSAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab DR5 Mouse FAP Mouse Inquiry
IGFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv DR5 Mouse FAP Mouse Inquiry
BSDB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody DR5 Mouse FAP Mouse Inquiry
BSFAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab DR5 Mouse FAP Mouse Inquiry
BSFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv DR5 Mouse FAP Mouse Inquiry
BSTF-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CEA Mouse DR5 Mouse Inquiry
BSTF-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse FAP Mouse Inquiry
BSCFV-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scFv-Fc) Human scFv-Fc CEA Mouse DR5 Mouse Inquiry
BSCFV-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse FAP Mouse Inquiry
BSCFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-Fc) Human scFv-Fc CEA Mouse DR5 Mouse Inquiry
BSCFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse FAP Mouse Inquiry
MNAB-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Miniantibody) Human Miniantibody CEA Mouse DR5 Mouse Inquiry
MNAB-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse FAP Mouse Inquiry
MNAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Miniantibody) Human Miniantibody CEA Mouse DR5 Mouse Inquiry
MNAB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse FAP Mouse Inquiry
BSFC-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CEA Mouse DR5 Mouse Inquiry
BSFC-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse FAP Mouse Inquiry
BSFC-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CEA Mouse DR5 Mouse Inquiry
BSFC-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse FAP Mouse Inquiry
BSCC-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CEA Mouse DR5 Mouse Inquiry
BSCC-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse FAP Mouse Inquiry
BSCC-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CEA Mouse DR5 Mouse Inquiry
BSCC-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse FAP Mouse Inquiry
BIBD-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Bibody) Human Bibody CEA Mouse DR5 Mouse Inquiry
BIBD-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Bibody) Human Bibody CD3 Mouse FAP Mouse Inquiry
BIBD-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Bibody) Human Bibody CEA Mouse DR5 Mouse Inquiry
BIBD-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Bibody) Human Bibody CD3 Mouse FAP Mouse Inquiry
FABFV-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Fab-Fv) Human Fab-Fv CEA Human DR5 Human Inquiry
FABFV-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human FAP Human Inquiry
FABFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-Fv) Human Fab-Fv CEA Mouse DR5 Mouse Inquiry
FABFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse FAP Mouse Inquiry
MiniB-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Minibody) Human Minibody CEA Human DR5 Human Inquiry
MiniB-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Minibody) Human Minibody CD3 Human FAP Human Inquiry
MiniB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Minibody) Human Minibody CEA Mouse DR5 Mouse Inquiry
MiniB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Minibody) Human Minibody CD3 Mouse FAP Mouse Inquiry
SCTB-H151 Recombinant Human Anti-FAP x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human FAP Human Inquiry
SCDB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CEA Human DR5 Human Inquiry
SCDB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human FAP Human Inquiry
FABIG-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA Human DR5 Human Inquiry
FABIG-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human FAP Human Inquiry
TRIB-H308 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CEA Human DR5 Human Inquiry
TRIB-H256 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human FAP Human Inquiry
BSIG-H306 Human Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA Human DR5 Human Inquiry
BSIG-H254 Human Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human FAP Human Inquiry
CROSSAB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (CrossMab) Human CrossMab CEA Human DR5 Human Inquiry
CROSSAB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab CD3 Human FAP Human Inquiry
IGFV-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA Human DR5 Human Inquiry
IGFV-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human FAP Human Inquiry
BSDB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody) Human Diabody CEA Human DR5 Human Inquiry
BSDB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody CD3 Human FAP Human Inquiry
BSFAB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA Human DR5 Human Inquiry
BSFAB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human FAP Human Inquiry
BSFV-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA Human DR5 Human Inquiry
BSFV-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human FAP Human Inquiry
SCTB-053 Recombinant Anti-FAP x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse FAP Mouse Inquiry
SCDB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CEA Mouse DR5 Mouse Inquiry
SCDB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse FAP Mouse Inquiry
FABIG-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA Mouse DR5 Mouse Inquiry
FABIG-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse FAP Mouse Inquiry
TRIB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CEA Mouse DR5 Mouse Inquiry
TRIB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse FAP Mouse Inquiry
BSIG-136 Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA Mouse DR5 Mouse Inquiry
BSIG-080 Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse FAP Mouse Inquiry
CROSSAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (CrossMab) Human CrossMab CEA Mouse DR5 Mouse Inquiry
CROSSAB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse FAP Mouse Inquiry
IGFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA Mouse DR5 Mouse Inquiry
IGFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse FAP Mouse Inquiry
BSDB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody) Human Diabody CEA Mouse DR5 Mouse Inquiry
BSDB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody CD3 Mouse FAP Mouse Inquiry
BSFAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA Mouse DR5 Mouse Inquiry
BSFAB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse FAP Mouse Inquiry
BSFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA Mouse DR5 Mouse Inquiry
BSFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse FAP Mouse Inquiry

Background

Death receptor 5 (DR5) and fibroblast-activation protein (FAP) are both instrumental regulators involved with different processes of tumors. DR5, a member of the TNF-receptor superfamily, is initially recognized as a cell receptor of TRAIL. DR5 participates in apoptosis via the formation of death-inducing signaling complexes, thus triggering multiple downstream signaling pathways. As inducing apoptosis in cancer cells has long been a popular drug R&D strategy for various cancers, DR5 attracts much attention as a promising target. FAP is a homodimeric membrane protein possessing high expression levels in reactive stromal fibroblasts of most epithelial malignancies. It plays important roles in the development, growth, and metastasis of tumors and is also regarded as an ideal target for cancer therapeutics.

DR5&FAP bispecific antibodies (BsAbs) can synchronously target DR5 on tumor cells and FAP on cancer-associated fibroblasts in tumor stroma, exhibiting the ability to activate potent tumor cell apoptosis in vitro and in vivo in preclinical tumor models.

Signaling pathways of DR5 (a) and FAP (b). (Dubuisson, et al, 2017; Fitzgerald, et al, 2020) Fig.1 DR5 pathway (a) and FAP pathway (b).1, 2

References

  1. Dubuisson, Agathe, and Olivier Micheau. "Antibodies and derivatives targeting DR4 and DR5 for cancer therapy." Antibodies 6.4 (2017): 16.
  2. Fitzgerald, Allison A., and Louis M. Weiner. "The role of fibroblast activation protein in health and malignancy." Cancer and Metastasis Reviews 39.3 (2020): 783-803.
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