FAS (First apoptosis signal receptor), also referred to APO-1, APT1, CD95 or TNFRSF6 (Tumor necrosis factor receptor superfamily member 6), is a type I transmembrane glycoprotein with 335 amino acids encoded by the gene mapping at the chromosome 10q23.31. It is a 37.7 kDa cell surface death receptor ubiquitously expressed in human bodies. FAS belongs to the tumor necrosis factor (TNF)-receptor superfamily and producing one of the proteins important to apoptosis. Three FAS proteins group forms a trimer that interacts with other molecules to perform its signaling function, finally initiating a process of caspase cascade. It contributes to immune homeostasis, elimination of infected cells, and plays an essential role in peripheral tolerance. More recently, it has been demonstrated to promote carcinogenesis. CSPG4 (Chondroitin sulfate proteoglycan 4), also known as MCSP (Melanoma-associated chondroitin sulfate proteoglycan), NG2 (Neuron-glial antigen 2) or gp 240, is a unique glycoprotein-proteoglycan complex that in humans is encoded by the gene CSPG4. It is regarded as a well-characterized melanoma cell-surface antigen and involved in numerous aspects of melanoma cell biology. NG2 is the protein with a 250 kDa core glycoprotein which the more than 450 kDa proteoglycan component is attached to. Except human melanomas, this anti-tumor target antigen is still expressed on other tumors including gliomas, neuroblastomas, breast carcinomas, and acute leukemias. And it plays an essential role in tumor cell invasion, migration, and angiogenesis.