Fibroblast growth factors (FGFs) belong to a family of cytokines and are formed a large family of polypeptide growth factors from nematodes to humans. With a strong mitogenic and chemoattractant activity, FGFs play a part in endothelial cells (EC) recruitment and proliferation. FGFs are potent regulators of cell proliferation, differentiation and function and are critically important in normal development, tissue maintenance, wound repair and angiogenesis. Some FGFs expressed in adult tissue is crucial for neuronal signal transduction in the central and peripheral nervous systems. A subset of the FGF family is homeostatic factors and function in tissue repair and response to injury in the adult organism. Inappropriate expression of FGFs is associated with the pathogenesis of cancer. VEGFA (Vascular endothelial growth factor A), also known as VPF, VEGF or MVCD1, is the most potent growth factor for endothelial cells and belongs to the PDGF/VEGF growth factor family. In humans, it is encoded by the VEGFA gene localizing at the chromosome 6p21.1. VEGF-A, as well as VEGF-C, and -D are found in the lung. During the embryonic and pseudoglandular stages, it is expressed in epithelial and mesenchymal compartments, then becoming more restricted to the epithelium as development process. VEGFA encodes a heparin-binding protein existing as a disulfide-linked homodimer. This growth factor is involved in inducing proliferation and migration of vascular endothelial cells. It is essential for physiological and pathological angiogenesis and considered as a powerful vascular permeability-enhancing agent.