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FIXa & FX Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H327 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Tandem Diabody) Human Tandem Diabody FIXa Human FX Human Inquiry
T-BSDB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Tandem Diabody) Human Tandem Diabody FIXa Mouse FX Mouse Inquiry
KN-1022-LN5 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Common light chain) (BsIgG) Human BsIgG FIXa Human FX Human Inquiry
SCIGG-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scIgG) Human Single chain IgGs FIXa Human FX Human Inquiry
SCIGG-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scIgG) Human Single chain IgGs FIXa Mouse FX Mouse Inquiry
BSAB-001 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (KIH-IgG) Human KIH-IgG FIXa Human FX Human Inquiry
FVTIG-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv4-Ig) Human scFv4-Ig FIXa Human FX Human Inquiry
FVTIG-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv4-Ig) Human scFv4-Ig FIXa Mouse FX Mouse Inquiry
BSSG-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv-IgG) Human scFv-IgG FIXa Human FX Human Inquiry
BSSG-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv-IgG) Human scFv-IgG FIXa Mouse FX Mouse Inquiry
IGLFV-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv FIXa Human FX Human Inquiry
IGLFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv FIXa Mouse FX Mouse Inquiry
BSGV-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (IgG-Fv) Human IgG-Fv FIXa Mouse FX Mouse Inquiry
BSGV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (IgG-Fv) Human IgG-Fv FIXa Mouse FX Mouse Inquiry
BSDG-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Fv-IgG) Human Fv-IgG FIXa Human FX Human Inquiry
BSDG-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fv-IgG) Human Fv-IgG FIXa Mouse FX Mouse Inquiry
BABFV-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 FIXa Human FX Human Inquiry
BABFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 FIXa Mouse FX Mouse Inquiry
FABVC-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc FIXa Human FX Human Inquiry
FABVC-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc FIXa Mouse FX Mouse Inquiry
SCDBC-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 FIXa Human FX Human Inquiry
SCDBC-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 FIXa Mouse FX Mouse Inquiry
BSDBC-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 FIXa Human FX Human Inquiry
BSDBC-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 FIXa Mouse FX Mouse Inquiry
SCDBF-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc FIXa Human FX Human Inquiry
SCDBF-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc FIXa Mouse FX Mouse Inquiry
BSFVF-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc FIXa Human FX Human Inquiry
BSFVF-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc FIXa Mouse FX Mouse Inquiry
BSDBF-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Diabody-Fc) Human Diabody-Fc FIXa Human FX Human Inquiry
BSDBF-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Diabody-Fc) Human Diabody-Fc FIXa Mouse FX Mouse Inquiry
BSTF-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv FIXa Mouse FX Mouse Inquiry
BSTF-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv FIXa Mouse FX Mouse Inquiry
BSCFV-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv-Fc) Human scFv-Fc FIXa Mouse FX Mouse Inquiry
BSCFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv-Fc) Human scFv-Fc FIXa Mouse FX Mouse Inquiry
MNAB-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Miniantibody) Human Miniantibody FIXa Mouse FX Mouse Inquiry
MNAB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Miniantibody) Human Miniantibody FIXa Mouse FX Mouse Inquiry
BSFC-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv-CH3) Human scFv-CH3 FIXa Mouse FX Mouse Inquiry
BSFC-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv-CH3) Human scFv-CH3 FIXa Mouse FX Mouse Inquiry
BSCC-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL FIXa Mouse FX Mouse Inquiry
BSCC-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL FIXa Mouse FX Mouse Inquiry
BIBD-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Bibody) Human Bibody FIXa Mouse FX Mouse Inquiry
BIBD-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Bibody) Human Bibody FIXa Mouse FX Mouse Inquiry
FABFV-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Fab-Fv) Human Fab-Fv FIXa Human FX Human Inquiry
FABFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-Fv) Human Fab-Fv FIXa Mouse FX Mouse Inquiry
MiniB-H328 Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Minibody) Human Minibody FIXa Human FX Human Inquiry
MiniB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Minibody) Human Minibody FIXa Mouse FX Mouse Inquiry
SCDB-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody FIXa Human FX Human Inquiry
FABIG-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Fab-IgG) Human Fab-IgG FIXa Human FX Human Inquiry
TRIB-H329 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv FIXa Human FX Human Inquiry
BSIG-H327 Human Anti-FIXa x Anti-FX Bispecific Antibody (IgG-IgG) Human IgG-IgG FIXa Human FX Human Inquiry
CROSSAB-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (CrossMab) Human CrossMab FIXa Human FX Human Inquiry
IGFV-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (IgG-scFv) Human IgG-scFv FIXa Human FX Human Inquiry
BSDB-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Diabody) Human Diabody FIXa Human FX Human Inquiry
BSFAB-H327 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Tandem Fab) Human Tandem Fab FIXa Human FX Human Inquiry
BSFV-H325 Recombinant Human Anti-FIXa x Anti-FX Bispecific Antibody (Tandem scFv) Human Tandem scFv FIXa Human FX Human Inquiry
SCDB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody FIXa Mouse FX Mouse Inquiry
FABIG-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-IgG) Human Fab-IgG FIXa Mouse FX Mouse Inquiry
TRIB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv FIXa Mouse FX Mouse Inquiry
BSIG-162 Anti-FIXa x Anti-FX Bispecific Antibody (IgG-IgG) Human IgG-IgG FIXa Mouse FX Mouse Inquiry
CROSSAB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (CrossMab) Human CrossMab FIXa Mouse FX Mouse Inquiry
IGFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (IgG-scFv) Human IgG-scFv FIXa Mouse FX Mouse Inquiry
BSDB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Diabody) Human Diabody FIXa Mouse FX Mouse Inquiry
BSFV-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Tandem scFv) Human Tandem scFv FIXa Mouse FX Mouse Inquiry
BSFAB-162 Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Tandem Fab) Human Tandem Fab FIXa Mouse FX Mouse Inquiry

Background

FIXa and FX are proteins involved in the blood clotting cascade, a vital process for maintaining hemostasis. FIXa is a serine protease that activates FX (also called prothrombinase), which then converts prothrombin to thrombin. Thrombin, afterward, breaks down fibrinogen into fibrin, the protein that forms the scaffold of blood clots. Anti-FIXa×anti-FX bispecific antibody (BsAb) is a type of immunotherapy designed to target both FIXa and FX, thereby blocking their interaction and inhibiting blood clot formation. This BsAb therapy shows potential in the treatment of bleeding disorders such as hemophilia and thromboembolic disorders such as deep vein thrombosis and pulmonary embolism, as well as in the prevention of thrombus formation during surgery.

Fig.1 Function of a BsAb binding to FIXa and FX. (Sampei, et al., 2013) Fig.1 A BsAb binding to FIXa and FX as well as its function.1

Reference

  1. Sampei, Zenjiro, et al. "Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity." PloS one8.2 (2013): e57479.
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