Product List
Background
Product List
Background
The glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR), a member of the TNF receptor superfamily, comprises multiple functional domains critical for immune modulation. Structurally, it contains extracellular cysteine-rich domains mediating ligand binding, a transmembrane domain, and intracellular regions with TRAF-binding motifs essential for downstream signaling cascades. Functionally, GITR exerts dual roles in immunoregulation: it enhances effector T-cell activation and survival while suppressing regulatory T-cell (Treg) immunosuppressive activity, thereby tipping the balance toward antitumor immunity. This receptor-ligand interaction triggers NF-κB and MAPK pathways, amplifying inflammatory cytokine production (e.g., IL-2, IFN-γ) and promoting cytotoxic lymphocyte proliferation. Recent therapeutic strategies exploit GITR agonism through monoclonal antibodies to overcome tumor immune evasion, particularly when combined with PD-1/PD-L1 checkpoint inhibitors, demonstrating synergistic efficacy in preclinical models. The receptor's structural complexity necessitates sophisticated antibody engineering to achieve optimal agonistic activity without excessive systemic immune activation. Current clinical development focuses on optimizing epitope specificity and Fc receptor interactions to enhance tumor microenvironment targeting while minimizing off-tumor effects.
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
Welcome! For price inquiries, we will get back to you as soon as possible.
To order, please email
INQUIRY
