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gpA33 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H260 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human gpA33 Human Inquiry
T-BSDB-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse gpA33 Mouse Inquiry
SCIGG-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human gpA33 Human Inquiry
SCIGG-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse gpA33 Mouse Inquiry
FVTIG-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human gpA33 Human Inquiry
FVTIG-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse gpA33 Mouse Inquiry
BSSG-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human gpA33 Human Inquiry
BSSG-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse gpA33 Mouse Inquiry
IGLFV-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human gpA33 Human Inquiry
IGLFV-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse gpA33 Mouse Inquiry
BSGV-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Human gpA33 Human Inquiry
BSGV-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse gpA33 Mouse Inquiry
BSDG-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human gpA33 Human Inquiry
BSDG-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse gpA33 Mouse Inquiry
BABFV-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human gpA33 Human Inquiry
BABFV-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse gpA33 Mouse Inquiry
FABVC-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human gpA33 Human Inquiry
FABVC-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse gpA33 Mouse Inquiry
SCDBC-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human gpA33 Human Inquiry
SCDBC-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse gpA33 Mouse Inquiry
BSDBC-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human gpA33 Human Inquiry
BSDBC-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse gpA33 Mouse Inquiry
SCDBF-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human gpA33 Human Inquiry
SCDBF-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse gpA33 Mouse Inquiry
BSFVF-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human gpA33 Human Inquiry
BSFVF-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse gpA33 Mouse Inquiry
BSDBF-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human gpA33 Human Inquiry
BSDBF-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse gpA33 Mouse Inquiry
BSTF-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Human gpA33 Human Inquiry
BSTF-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse gpA33 Mouse Inquiry
BSCFV-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Human gpA33 Human Inquiry
BSCFV-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse gpA33 Mouse Inquiry
MNAB-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Human gpA33 Human Inquiry
MNAB-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse gpA33 Mouse Inquiry
BSFC-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Human gpA33 Human Inquiry
BSFC-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse gpA33 Mouse Inquiry
BSCC-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Human gpA33 Human Inquiry
BSCC-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse gpA33 Mouse Inquiry
BIBD-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (Bibody) Human Bibody CD3 Human gpA33 Human Inquiry
BIBD-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse gpA33 Mouse Inquiry
FABFV-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human gpA33 Human Inquiry
FABFV-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse gpA33 Mouse Inquiry
MiniB-H262 Recombinant Human Anti-CD3 x Human Anti-gpA33 Bispecific Antibody (Minibody) Human Minibody CD3 Human gpA33 Human Inquiry
MiniB-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse gpA33 Mouse Inquiry
SCTB-H157 Recombinant Human Anti-gpA33 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human gpA33 Human Inquiry
SCDB-H260 Recombinant Human Anti-CD3 x Anti-gpA33 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human gpA33 Human Inquiry
FABIG-H260 Recombinant Human Anti-CD3 x Anti-gpA33 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human gpA33 Human Inquiry
TRIB-H262 Recombinant Human Anti-CD3 x Anti-gpA33 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human gpA33 Human Inquiry
BSIG-H260 Human Anti-CD3 x Anti-gpA33 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human gpA33 Human Inquiry
CROSSAB-H260 Recombinant Human Anti-CD3 x Anti-gpA33 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human gpA33 Human Inquiry
IGFV-H260 Recombinant Human Anti-CD3 x Anti-gpA33 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human gpA33 Human Inquiry
BSDB-H260 Recombinant Human Anti-CD3 x Anti-gpA33 Bispecific Antibody (Diabody) Human Diabody CD3 Human gpA33 Human Inquiry
BSFAB-H260 Recombinant Human Anti-CD3 x Anti-gpA33 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human gpA33 Human Inquiry
BSFV-H260 Recombinant Human Anti-CD3 x Anti-gpA33 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human gpA33 Human Inquiry
SCTB-059 Recombinant Anti-gpA33 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse gpA33 Mouse Inquiry
SCDB-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse gpA33 Mouse Inquiry
FABIG-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse gpA33 Mouse Inquiry
TRIB-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse gpA33 Mouse Inquiry
BSIG-086 Anti-CD3 x Anti-gpA33 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse gpA33 Mouse Inquiry
CROSSAB-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse gpA33 Mouse Inquiry
IGFV-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse gpA33 Mouse Inquiry
BSDB-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse gpA33 Mouse Inquiry
BSFAB-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse gpA33 Mouse Inquiry
BSFV-086 Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse gpA33 Mouse Inquiry

Background

Glycoprotein A33 (gpA33) is a cell surface differentiation antigen that exhibits an extensive homology with CD2. Predominantly expressed in normal intestinal tissue and the majority of colorectal tumors whilst possessing minimal presence in other tissues, it is considered a significant target for colorectal cancer detection and the development of immunotherapeutic interventions. Current research exemplifies the utilization of bifunctional antibodies specific to both gpA33 and CD3 as a means of facilitating the activation of T cells to target tumor tissues.

gpA33 is confirmed to correlate with immune dysregulation. Its genetic polymorphisms demonstrate genetic associations with various autoimmune diseases, and any deficiency in its expression could potentially affect inflammatory responses. Additionally, recent findings indicate a notable presence of gpA33 on several types of leukocytes, suggesting its involvement in immune regulation.

Expression of gpA33. (Opstelten, et al., 2021) Fig.1 Expression of gpA33.1

Reference

  1. Opstelten, Suwandi, et al. " gpA33 is expressed on multiple human blood cell types and distinguishes CD4+ central memory T cells with and without effector function." European Journal of Immunology. 51 (2021): 1377.
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