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GPNMB Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H262 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human GPNMB Human Inquiry
T-BSDB-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse GPNMB Mouse Inquiry
SCIGG-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human GPNMB Human Inquiry
FABVC-382 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse GPNMB llama Inquiry
BSSG-382 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (sdAb-IgG) Human sdAb-IgG CD3 Mouse GPNMB llama Inquiry
HCAB-027 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb CD3 llama GPNMB llama Inquiry
BIBD-382 Recombinant Anti-CD3 x Anti-GPNMB VHH BispecificAntibody (Bibody) Human Bibody CD3 Mouse GPNMB llama Inquiry
IGVHH-027 Recombinant Anti-CD3 x Anti-GPNMB sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb CD3 Mouse GPNMB llama Inquiry
BIVHH-027 Recombinant Anti-CD3 sdAb x Anti-GPNMB sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb CD3 llama GPNMB llama Inquiry
SCIGG-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse GPNMB Mouse Inquiry
FVTIG-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human GPNMB Human Inquiry
FVTIG-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse GPNMB Mouse Inquiry
BSSG-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human GPNMB Human Inquiry
BSSG-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse GPNMB Mouse Inquiry
IGLFV-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human GPNMB Human Inquiry
IGLFV-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse GPNMB Mouse Inquiry
BSGV-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse GPNMB Mouse Inquiry
BSGV-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse GPNMB Mouse Inquiry
BSDG-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human GPNMB Human Inquiry
BSDG-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse GPNMB Mouse Inquiry
BABFV-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human GPNMB Human Inquiry
BABFV-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse GPNMB Mouse Inquiry
FABVC-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human GPNMB Human Inquiry
FABVC-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse GPNMB Mouse Inquiry
SCDBC-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human GPNMB Human Inquiry
SCDBC-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse GPNMB Mouse Inquiry
BSDBC-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human GPNMB Human Inquiry
BSDBC-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse GPNMB Mouse Inquiry
SCDBF-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human GPNMB Human Inquiry
SCDBF-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse GPNMB Mouse Inquiry
BSFVF-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human GPNMB Human Inquiry
BSFVF-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse GPNMB Mouse Inquiry
BSDBF-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human GPNMB Human Inquiry
BSDBF-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse GPNMB Mouse Inquiry
BSTF-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse GPNMB Mouse Inquiry
BSTF-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse GPNMB Mouse Inquiry
BSCFV-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse GPNMB Mouse Inquiry
BSCFV-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse GPNMB Mouse Inquiry
MNAB-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse GPNMB Mouse Inquiry
MNAB-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse GPNMB Mouse Inquiry
BSFC-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse GPNMB Mouse Inquiry
BSFC-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse GPNMB Mouse Inquiry
BSCC-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse GPNMB Mouse Inquiry
BSCC-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse GPNMB Mouse Inquiry
BIBD-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (Bibody) Human Bibody CD3 Mouse GPNMB Mouse Inquiry
BIBD-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Bibody) Human Bibody CD3 Mouse GPNMB Mouse Inquiry
FABFV-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human GPNMB Human Inquiry
FABFV-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse GPNMB Mouse Inquiry
MiniB-H264 Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (Minibody) Human Minibody CD3 Human GPNMB Human Inquiry
MiniB-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Minibody) Human Minibody CD3 Mouse GPNMB Mouse Inquiry
SCTB-H159 Recombinant Human Anti-GPNMB x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human GPNMB Human Inquiry
SCDB-H262 Recombinant Human Anti-CD3 x Anti-GPNMB Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human GPNMB Human Inquiry
FABIG-H262 Recombinant Human Anti-CD3 x Anti-GPNMB Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human GPNMB Human Inquiry
TRIB-H264 Recombinant Human Anti-CD3 x Anti-GPNMB Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human GPNMB Human Inquiry
BSIG-H262 Human Anti-CD3 x Anti-GPNMB Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human GPNMB Human Inquiry
CROSSAB-H262 Recombinant Human Anti-CD3 x Anti-GPNMB Bispecific Antibody (CrossMab) Human CrossMab CD3 Human GPNMB Human Inquiry
IGFV-H262 Recombinant Human Anti-CD3 x Anti-GPNMB Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human GPNMB Human Inquiry
BSDB-H262 Recombinant Human Anti-CD3 x Anti-GPNMB Bispecific Antibody (Diabody) Human Diabody CD3 Human GPNMB Human Inquiry
BSFAB-H262 Recombinant Human Anti-CD3 x Anti-GPNMB Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human GPNMB Human Inquiry
BSFV-H262 Recombinant Human Anti-CD3 x Anti-GPNMB Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human GPNMB Human Inquiry
SCTB-061 Recombinant Anti-GPNMB x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse GPNMB Mouse Inquiry
SCDB-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse GPNMB Mouse Inquiry
FABIG-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse GPNMB Mouse Inquiry
TRIB-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse GPNMB Mouse Inquiry
BSIG-088 Anti-CD3 x Anti-GPNMB Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse GPNMB Mouse Inquiry
CROSSAB-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse GPNMB Mouse Inquiry
IGFV-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse GPNMB Mouse Inquiry
BSDB-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Diabody) Human Diabody CD3 Mouse GPNMB Mouse Inquiry
BSFAB-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse GPNMB Mouse Inquiry
BSFV-088 Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse GPNMB Mouse Inquiry

Background

GPNMB is an endogenous glycoprotein broadly expressed in an array of cells including melanocytes, dendritic cells, osteoblasts, macrophages, microglia, and osteoclasts. Its cellular functions vary significantly according to the type of cell in which it is expressed. Notably, GPNMB promotes ossification processes by inducing bone matrix mineralization and the activation of osteoblasts, impacts the proliferation and activation of fibroblasts, influences the maturation of hematopoietic and lymphatic cells, and down-regulates the activation of T lymphocytes.

Additionally, numerous studies have attested to the association of GPNMB with various types of tumors such as melanoma, glioblastoma, gastric cancer, and breast cancer. Although the exact mechanism of its participation remains to be fully elucidated, it has been suggested that GPNMB plays a protective role in specific types of cancer and could potentially be involved in cancer metastasis.

GPNMB intracellular signaling. (Saade, et al., 2021) Fig.1 GPNMB intracellular signaling.1

Reference

  1. Saade, Souza, et al. " The Role of GPNMB in Inflammation." Frontiers in Immunology. 12 (2021): 674739.
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