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HER1 & HER3 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H329 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody HER1 Human HER3 Human Inquiry
T-BSDB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody HER1 Mouse HER3 Mouse Inquiry
SCIGG-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (scIgG) Human Single chain IgGs HER1 Human HER3 Human Inquiry
SCIGG-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (scIgG) Human Single chain IgGs HER1 Mouse HER3 Mouse Inquiry
FVTIG-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig HER1 Human HER3 Human Inquiry
FVTIG-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig HER1 Mouse HER3 Mouse Inquiry
BSSG-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (scFv-IgG) Human scFv-IgG HER1 Human HER3 Human Inquiry
BSSG-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (scFv-IgG) Human scFv-IgG HER1 Mouse HER3 Mouse Inquiry
IGLFV-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (IgG(L)-scFv) Human IgG (L)-scFv HER1 Human HER3 Human Inquiry
IGLFV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG(L)-scFv) Human IgG (L)-scFv HER1 Mouse HER3 Mouse Inquiry
BSGV-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (IgG-Fv) Human IgG-Fv HER1 Mouse HER3 Mouse Inquiry
BSGV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-Fv) Human IgG-Fv HER1 Mouse HER3 Mouse Inquiry
BSDG-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (Fv-IgG) Human Fv-IgG HER1 Human HER3 Human Inquiry
BSDG-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Fv-IgG) Human Fv-IgG HER1 Mouse HER3 Mouse Inquiry
BABFV-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 HER1 Human HER3 Human Inquiry
BABFV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 HER1 Mouse HER3 Mouse Inquiry
FABVC-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc HER1 Human HER3 Human Inquiry
FABVC-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc HER1 Mouse HER3 Mouse Inquiry
SCDBC-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 HER1 Human HER3 Human Inquiry
SCDBC-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 HER1 Mouse HER3 Mouse Inquiry
BSDBC-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 HER1 Human HER3 Human Inquiry
BSDBC-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 HER1 Mouse HER3 Mouse Inquiry
SCDBF-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc HER1 Human HER3 Human Inquiry
SCDBF-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc HER1 Mouse HER3 Mouse Inquiry
BSFVF-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc HER1 Human HER3 Human Inquiry
BSFVF-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc HER1 Mouse HER3 Mouse Inquiry
BSDBF-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc HER1 Human HER3 Human Inquiry
BSDBF-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc HER1 Mouse HER3 Mouse Inquiry
BSTF-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv HER1 Mouse HER3 Mouse Inquiry
BSTF-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv HER1 Mouse HER3 Mouse Inquiry
BSCFV-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (scFv-Fc) Human scFv-Fc HER1 Mouse HER3 Mouse Inquiry
BSCFV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (scFv-Fc) Human scFv-Fc HER1 Mouse HER3 Mouse Inquiry
MNAB-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (Miniantibody) Human Miniantibody HER1 Mouse HER3 Mouse Inquiry
MNAB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Miniantibody) Human Miniantibody HER1 Mouse HER3 Mouse Inquiry
BSFC-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 HER1 Mouse HER3 Mouse Inquiry
BSFC-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 HER1 Mouse HER3 Mouse Inquiry
BSCC-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL HER1 Mouse HER3 Mouse Inquiry
BSCC-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL HER1 Mouse HER3 Mouse Inquiry
BIBD-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (Bibody) Human Bibody HER1 Mouse HER3 Mouse Inquiry
BIBD-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Bibody) Human Bibody HER1 Mouse HER3 Mouse Inquiry
FABFV-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (Fab-Fv) Human Fab-Fv HER1 Human HER3 Human Inquiry
FABFV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-Fv) Human Fab-Fv HER1 Mouse HER3 Mouse Inquiry
MiniB-H330 Recombinant Human Anti-HER1 x Human Anti-HER3 Bispecific Antibody (Minibody) Human Minibody HER1 Human HER3 Human Inquiry
MiniB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Minibody) Human Minibody HER1 Mouse HER3 Mouse Inquiry
BSFAB-SAR031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-SAR013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFAB-NGB031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-NGB013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFAB-MEL031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-MEL013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFAB-BGN031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-BGN013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFAB-ABR031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-ABR013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFAB-PAP031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-PAP013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFAB-SAP031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-SAP013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFAB-RTA031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-RTA013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFAB-GEL031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-GEL013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFAB-PE031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-PE013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFAB-DT031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFAB-DT013 Recombinant Anti-HER1 x Anti-HER3 Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFV-SAR031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFV-SAR013 Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFV-NGB031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFV-NGB013 Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFV-MEL031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFV-MEL013 Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFV-BGN031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFV-BGN013 Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFV-ABR031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFV-ABR013 Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
BSFV-PAP031 Recombinant Human Anti-HER1 x Human Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Human HER3 Human Inquiry
BSFV-PAP013 Recombinant Anti-HER1 x Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER1 Mouse HER3 Mouse Inquiry
SCDB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER1 Human HER3 Human Inquiry
FABIG-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER1 Human HER3 Human Inquiry
TRIB-H331 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER1 Human HER3 Human Inquiry
BSIG-H329 Human Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER1 Human HER3 Human Inquiry
CROSSAB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER1 Human HER3 Human Inquiry
IGFV-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER1 Human HER3 Human Inquiry
BSDB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER1 Human HER3 Human Inquiry
BSFAB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER1 Human HER3 Human Inquiry
BSFV-H327 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER1 Human HER3 Human Inquiry
SCDB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER1 Mouse HER3 Mouse Inquiry
FABIG-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER1 Mouse HER3 Mouse Inquiry
TRIB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER1 Mouse HER3 Mouse Inquiry
BSIG-165 Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER1 Mouse HER3 Mouse Inquiry
CROSSAB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER1 Mouse HER3 Mouse Inquiry
IGFV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER1 Mouse HER3 Mouse Inquiry
BSDB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER1 Mouse HER3 Mouse Inquiry
BSFAB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER1 Mouse HER3 Mouse Inquiry
BSFV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER1 Mouse HER3 Mouse Inquiry
BSFV-MEL028 Recombinant Human Anti-EGFR x Human Anti-HER3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human HER3 Human Inquiry
BSFV-MEL016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-MEL015 Recombinant Anti-HER2 x Anti-HER3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Mouse HER3 Mouse Inquiry
BSFV-MEL010 Recombinant Anti-EGFR x Anti-HER3 Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse HER3 Mouse Inquiry
BSFV-BGN034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-BGN033 Recombinant Human Anti-HER2 x Human Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Human HER3 Human Inquiry
BSFV-BGN028 Recombinant Human Anti-EGFR x Human Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human HER3 Human Inquiry
BSFV-BGN016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-BGN015 Recombinant Anti-HER2 x Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Mouse HER3 Mouse Inquiry
BSFV-BGN010 Recombinant Anti-EGFR x Anti-HER3 Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse HER3 Mouse Inquiry
BSFV-ABR034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-ABR033 Recombinant Human Anti-HER2 x Human Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Human HER3 Human Inquiry
BSFV-ABR028 Recombinant Human Anti-EGFR x Human Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human HER3 Human Inquiry
BSFV-ABR016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-ABR015 Recombinant Anti-HER2 x Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Mouse HER3 Mouse Inquiry
BSFV-ABR010 Recombinant Anti-EGFR x Anti-HER3 Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse HER3 Mouse Inquiry
BSFV-PAP034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-PAP033 Recombinant Human Anti-HER2 x Human Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Human HER3 Human Inquiry
BSFV-PAP028 Recombinant Human Anti-EGFR x Human Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Human HER3 Human Inquiry
BSFV-PAP016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-PAP015 Recombinant Anti-HER2 x Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER2 Mouse HER3 Mouse Inquiry
BSFV-PAP010 Recombinant Anti-EGFR x Anti-HER3 Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin EGFR Mouse HER3 Mouse Inquiry
SCDB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER3 Human IGF1R Human Inquiry
SCDB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER2 Human HER3 Human Inquiry
SCDB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody EGFR Human HER3 Human Inquiry
FABIG-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG HER3 Human IGF1R Human Inquiry
FABIG-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Human HER3 Human Inquiry
FABIG-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Human HER3 Human Inquiry
TRIB-H335 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER3 Human IGF1R Human Inquiry
TRIB-H333 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Human HER3 Human Inquiry
TRIB-H324 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Human HER3 Human Inquiry
BSIG-H333 Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG HER3 Human IGF1R Human Inquiry
BSIG-H331 Human Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Human HER3 Human Inquiry
BSIG-H322 Human Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Human HER3 Human Inquiry
CROSSAB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab HER3 Human IGF1R Human Inquiry
CROSSAB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER2 Human HER3 Human Inquiry
CROSSAB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab EGFR Human HER3 Human Inquiry
IGFV-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv HER3 Human IGF1R Human Inquiry
IGFV-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Human HER3 Human Inquiry
IGFV-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Human HER3 Human Inquiry
BSDB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody HER3 Human IGF1R Human Inquiry
BSDB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER2 Human HER3 Human Inquiry
BSDB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody EGFR Human HER3 Human Inquiry
BSFAB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab HER3 Human IGF1R Human Inquiry
BSFAB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Human HER3 Human Inquiry
BSFAB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Human HER3 Human Inquiry
BSFV-H331 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv HER3 Human IGF1R Human Inquiry
BSFV-H329 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Human HER3 Human Inquiry
BSFV-H320 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Human HER3 Human Inquiry
SCDB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER3 Mouse IGF1R Mouse Inquiry
SCDB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER2 Mouse HER3 Mouse Inquiry
SCDB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody EGFR Mouse HER3 Mouse Inquiry
FABIG-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG HER3 Mouse IGF1R Mouse Inquiry
FABIG-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Mouse HER3 Mouse Inquiry
FABIG-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Mouse HER3 Mouse Inquiry
TRIB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER3 Mouse IGF1R Mouse Inquiry
TRIB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Mouse HER3 Mouse Inquiry
TRIB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse HER3 Mouse Inquiry
BSIG-169 Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG HER3 Mouse IGF1R Mouse Inquiry
BSIG-167 Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Mouse HER3 Mouse Inquiry
BSIG-156 Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse HER3 Mouse Inquiry
CROSSAB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER2 Mouse HER3 Mouse Inquiry
IGFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv HER3 Mouse IGF1R Mouse Inquiry
IGFV-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Mouse HER3 Mouse Inquiry
IGFV-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse HER3 Mouse Inquiry
BSDB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody HER3 Mouse IGF1R Mouse Inquiry
BSDB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER2 Mouse HER3 Mouse Inquiry
BSDB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody EGFR Mouse HER3 Mouse Inquiry
BSFAB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab HER3 Mouse IGF1R Mouse Inquiry
BSFAB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Mouse HER3 Mouse Inquiry
BSFAB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse HER3 Mouse Inquiry
BSFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv HER3 Mouse IGF1R Mouse Inquiry
BSFV-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Mouse HER3 Mouse Inquiry
BSFV-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse HER3 Mouse Inquiry

Background

Fig. 1 Schematic diagram of HER1 & HER3. (Schaefer, et al, 2011)Fig. 1 The structure of HER1 and HER3 proteins.1

HER1 (EGFR) and HER3 belong to the HER family. HER1 can induce tumor proliferation through homodimerization. HER1 is overexpressed in many solid tumors, including lung, colon, and breast cancers. HER3 works by forming active heterodimers with other HER members, mainly HER1 or HER2. High HER3 expression is correlated with cancer progression and/or poor prognosis, making it an important marker for poor overall survival in diverse solid tumors. In addition, HER3 has been demonstrated associated with resistance mechanisms to HER1 therapy. Simultaneous targeting of multiple HER family targets becomes a possible approach to address HER1 resistance. The anti-HER1 x anti-HER3 bispecific antibody (BsAb) can target both HER1 and HER3, which is expected to improve HER1 resistance. This BsAb can be used in therapeutic studies for breast, ovarian, and colon cancers.

Reference

  1. Schaefer, G.; et al. A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell. 2011, 20(4): 472-86.
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