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HER3 & IGF1R Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H333 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (Tandem Diabody) Human Tandem Diabody HER3 Human IGF1R Human Inquiry
T-BSDB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem Diabody) Human Tandem Diabody HER3 Mouse IGF1R Mouse Inquiry
SCIGG-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (scIgG) Human Single chain IgGs HER3 Human IGF1R Human Inquiry
FABVC-406 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc HER3 Mouse IGF1R llama Inquiry
BSSG-406 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (sdAb-IgG) Human sdAb-IgG HER3 Mouse IGF1R llama Inquiry
HCAB-051 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb HER3 llama IGF1R llama Inquiry
BIBD-406 Recombinant Anti-HER3 x Anti-IGF1R VHH BispecificAntibody (Bibody) Human Bibody HER3 Mouse IGF1R llama Inquiry
IGVHH-051 Recombinant Anti-HER3 x Anti-IGF1R sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb HER3 Mouse IGF1R llama Inquiry
BIVHH-051 Recombinant Anti-HER3 sdAb x Anti-IGF1R sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb HER3 llama IGF1R llama Inquiry
SCIGG-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scIgG) Human Single chain IgGs HER3 Mouse IGF1R Mouse Inquiry
FVTIG-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (scFv4-Ig) Human scFv4-Ig HER3 Human IGF1R Human Inquiry
FVTIG-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv4-Ig) Human scFv4-Ig HER3 Mouse IGF1R Mouse Inquiry
BSSG-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (scFv-IgG) Human scFv-IgG HER3 Human IGF1R Human Inquiry
BSSG-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv-IgG) Human scFv-IgG HER3 Mouse IGF1R Mouse Inquiry
IGLFV-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (IgG(L)-scFv) Human IgG (L)-scFv HER3 Human IGF1R Human Inquiry
IGLFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG(L)-scFv) Human IgG (L)-scFv HER3 Mouse IGF1R Mouse Inquiry
BSGV-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (IgG-Fv) Human IgG-Fv HER3 Mouse IGF1R Mouse Inquiry
BSGV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-Fv) Human IgG-Fv HER3 Mouse IGF1R Mouse Inquiry
BSDG-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (Fv-IgG) Human Fv-IgG HER3 Human IGF1R Human Inquiry
BSDG-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fv-IgG) Human Fv-IgG HER3 Mouse IGF1R Mouse Inquiry
BABFV-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 HER3 Human IGF1R Human Inquiry
BABFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 HER3 Mouse IGF1R Mouse Inquiry
FABVC-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc HER3 Human IGF1R Human Inquiry
FABVC-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc HER3 Mouse IGF1R Mouse Inquiry
SCDBC-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 HER3 Human IGF1R Human Inquiry
SCDBC-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 HER3 Mouse IGF1R Mouse Inquiry
BSDBC-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 HER3 Human IGF1R Human Inquiry
BSDBC-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 HER3 Mouse IGF1R Mouse Inquiry
SCDBF-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc HER3 Human IGF1R Human Inquiry
SCDBF-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc HER3 Mouse IGF1R Mouse Inquiry
BSFVF-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc HER3 Human IGF1R Human Inquiry
BSFVF-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc HER3 Mouse IGF1R Mouse Inquiry
BSDBF-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (Diabody-Fc) Human Diabody-Fc HER3 Human IGF1R Human Inquiry
BSDBF-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Diabody-Fc) Human Diabody-Fc HER3 Mouse IGF1R Mouse Inquiry
BSTF-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv HER3 Mouse IGF1R Mouse Inquiry
BSTF-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv HER3 Mouse IGF1R Mouse Inquiry
BSCFV-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (scFv-Fc) Human scFv-Fc HER3 Mouse IGF1R Mouse Inquiry
BSCFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv-Fc) Human scFv-Fc HER3 Mouse IGF1R Mouse Inquiry
MNAB-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (Miniantibody) Human Miniantibody HER3 Mouse IGF1R Mouse Inquiry
MNAB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Miniantibody) Human Miniantibody HER3 Mouse IGF1R Mouse Inquiry
BSFC-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (scFv-CH3) Human scFv-CH3 HER3 Mouse IGF1R Mouse Inquiry
BSFC-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv-CH3) Human scFv-CH3 HER3 Mouse IGF1R Mouse Inquiry
BSCC-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL HER3 Mouse IGF1R Mouse Inquiry
BSCC-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL HER3 Mouse IGF1R Mouse Inquiry
BIBD-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (Bibody) Human Bibody HER3 Mouse IGF1R Mouse Inquiry
BIBD-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Bibody) Human Bibody HER3 Mouse IGF1R Mouse Inquiry
FABFV-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (Fab-Fv) Human Fab-Fv HER3 Human IGF1R Human Inquiry
FABFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-Fv) Human Fab-Fv HER3 Mouse IGF1R Mouse Inquiry
MiniB-H334 Recombinant Human Anti-HER3 x Human Anti-IGF1R Bispecific Antibody (Minibody) Human Minibody HER3 Human IGF1R Human Inquiry
MiniB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Minibody) Human Minibody HER3 Mouse IGF1R Mouse Inquiry
BSFAB-SAR034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-SAR016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-NGB034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-NGB016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-MEL034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-MEL016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-BGN034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-BGN016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-ABR034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-ABR016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-PAP034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-PAP016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-SAP034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-SAP016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-RTA034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-RTA016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-GEL034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-GEL016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-PE034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-PE016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFAB-DT034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFAB-DT016 Recombinant Anti-HER3 x Anti-IGF1R Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-SAR034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-SAR016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-NGB034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-NGB016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-MEL034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-MEL016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-BGN034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-BGN016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-ABR034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-ABR016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
BSFV-PAP034 Recombinant Human Anti-HER3 x Human Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Human IGF1R Human Inquiry
BSFV-PAP016 Recombinant Anti-HER3 x Anti-IGF1R Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin HER3 Mouse IGF1R Mouse Inquiry
SCDB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER3 Human IGF1R Human Inquiry
FABIG-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG HER3 Human IGF1R Human Inquiry
TRIB-H335 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER3 Human IGF1R Human Inquiry
BSIG-H333 Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG HER3 Human IGF1R Human Inquiry
CROSSAB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab HER3 Human IGF1R Human Inquiry
IGFV-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv HER3 Human IGF1R Human Inquiry
BSDB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody HER3 Human IGF1R Human Inquiry
BSFAB-H333 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab HER3 Human IGF1R Human Inquiry
BSFV-H331 Recombinant Human Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv HER3 Human IGF1R Human Inquiry
SCDB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER3 Mouse IGF1R Mouse Inquiry
FABIG-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG HER3 Mouse IGF1R Mouse Inquiry
TRIB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER3 Mouse IGF1R Mouse Inquiry
BSIG-169 Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG HER3 Mouse IGF1R Mouse Inquiry
IGFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv HER3 Mouse IGF1R Mouse Inquiry
BSDB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody HER3 Mouse IGF1R Mouse Inquiry
BSFAB-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab HER3 Mouse IGF1R Mouse Inquiry
BSFV-169 Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv HER3 Mouse IGF1R Mouse Inquiry
FABIG-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Human HER3 Human Inquiry
FABIG-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER1 Human HER3 Human Inquiry
FABIG-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Human IGF1R Human Inquiry
FABIG-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Human HER3 Human Inquiry
FABIG-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human IGF1R Human Inquiry
TRIB-H333 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Human HER3 Human Inquiry
TRIB-H331 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER1 Human HER3 Human Inquiry
TRIB-H325 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Human IGF1R Human Inquiry
TRIB-H324 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Human HER3 Human Inquiry
TRIB-H268 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human IGF1R Human Inquiry
BSIG-H331 Human Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Human HER3 Human Inquiry
BSIG-H329 Human Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER1 Human HER3 Human Inquiry
BSIG-H323 Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Human IGF1R Human Inquiry
BSIG-H322 Human Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Human HER3 Human Inquiry
BSIG-H266 Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human IGF1R Human Inquiry
CROSSAB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER2 Human HER3 Human Inquiry
CROSSAB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER1 Human HER3 Human Inquiry
CROSSAB-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab EGFR Human IGF1R Human Inquiry
CROSSAB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab EGFR Human HER3 Human Inquiry
CROSSAB-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab CD3 Human IGF1R Human Inquiry
IGFV-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Human HER3 Human Inquiry
IGFV-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER1 Human HER3 Human Inquiry
IGFV-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Human IGF1R Human Inquiry
IGFV-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Human HER3 Human Inquiry
IGFV-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human IGF1R Human Inquiry
BSDB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER2 Human HER3 Human Inquiry
BSDB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER1 Human HER3 Human Inquiry
BSDB-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody EGFR Human IGF1R Human Inquiry
BSDB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody EGFR Human HER3 Human Inquiry
BSDB-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody CD3 Human IGF1R Human Inquiry
BSFAB-H331 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Human HER3 Human Inquiry
BSFAB-H329 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER1 Human HER3 Human Inquiry
BSFAB-H323 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Human IGF1R Human Inquiry
BSFAB-H322 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Human HER3 Human Inquiry
BSFAB-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human IGF1R Human Inquiry
BSFV-H329 Recombinant Human Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Human HER3 Human Inquiry
BSFV-H327 Recombinant Human Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER1 Human HER3 Human Inquiry
BSFV-H321 Recombinant Human Anti-EGFR x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Human IGF1R Human Inquiry
BSFV-H320 Recombinant Human Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Human HER3 Human Inquiry
BSFV-H266 Recombinant Human Anti-CD3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human IGF1R Human Inquiry
SCTB-065 Recombinant Anti-IGF1R x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse IGF1R Mouse Inquiry
SCDB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER2 Mouse HER3 Mouse Inquiry
SCDB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody HER1 Mouse HER3 Mouse Inquiry
SCDB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody EGFR Mouse IGF1R Mouse Inquiry
SCDB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody EGFR Mouse HER3 Mouse Inquiry
SCDB-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse IGF1R Mouse Inquiry
FABIG-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER2 Mouse HER3 Mouse Inquiry
FABIG-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG HER1 Mouse HER3 Mouse Inquiry
FABIG-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Mouse IGF1R Mouse Inquiry
FABIG-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-IgG) Human Fab-IgG EGFR Mouse HER3 Mouse Inquiry
FABIG-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse IGF1R Mouse Inquiry
TRIB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER2 Mouse HER3 Mouse Inquiry
TRIB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv HER1 Mouse HER3 Mouse Inquiry
TRIB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse IGF1R Mouse Inquiry
TRIB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv EGFR Mouse HER3 Mouse Inquiry
TRIB-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse IGF1R Mouse Inquiry
BSIG-167 Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER2 Mouse HER3 Mouse Inquiry
BSIG-165 Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG HER1 Mouse HER3 Mouse Inquiry
BSIG-157 Anti-EGFR x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse IGF1R Mouse Inquiry
BSIG-156 Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-IgG) Human IgG-IgG EGFR Mouse HER3 Mouse Inquiry
BSIG-092 Anti-CD3 x Anti-IGF1R Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse IGF1R Mouse Inquiry
CROSSAB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER2 Mouse HER3 Mouse Inquiry
CROSSAB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (CrossMab) Human CrossMab HER1 Mouse HER3 Mouse Inquiry
CROSSAB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab EGFR Mouse IGF1R Mouse Inquiry
CROSSAB-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse IGF1R Mouse Inquiry
IGFV-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER2 Mouse HER3 Mouse Inquiry
IGFV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv HER1 Mouse HER3 Mouse Inquiry
IGFV-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse IGF1R Mouse Inquiry
IGFV-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-scFv) Human IgG-scFv EGFR Mouse HER3 Mouse Inquiry
IGFV-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse IGF1R Mouse Inquiry
BSDB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER2 Mouse HER3 Mouse Inquiry
BSDB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody HER1 Mouse HER3 Mouse Inquiry
BSDB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody EGFR Mouse IGF1R Mouse Inquiry
BSDB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Diabody) Human Diabody EGFR Mouse HER3 Mouse Inquiry
BSDB-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Diabody) Human Diabody CD3 Mouse IGF1R Mouse Inquiry
BSFAB-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER2 Mouse HER3 Mouse Inquiry
BSFAB-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab HER1 Mouse HER3 Mouse Inquiry
BSFAB-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse IGF1R Mouse Inquiry
BSFAB-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem Fab) Human Tandem Fab EGFR Mouse HER3 Mouse Inquiry
BSFAB-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse IGF1R Mouse Inquiry
BSFV-167 Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER2 Mouse HER3 Mouse Inquiry
BSFV-165 Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv HER1 Mouse HER3 Mouse Inquiry
BSFV-157 Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse IGF1R Mouse Inquiry
BSFV-156 Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Tandem scFv) Human Tandem scFv EGFR Mouse HER3 Mouse Inquiry
BSFV-092 Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse IGF1R Mouse Inquiry

Background

HER3, known as Human Epidermal Growth Factor Receptor 3 and situated on the cellular membrane, is identified as a member of the tyrosine kinase receptor family. Despite its relatively weak intrinsic kinase activity, HER3 can activate key signaling pathways, such as PI3K/AKT, when it forms complexes with other receptors like HER2, thereby effectively promoting the growth and survival of tumor cells. IGF1R (Insulin-like Growth Factor 1 Receptor) contributes to the regulation of cellular growth and metabolic processes. By initiating signaling pathways like PI3K/AKT and MAPK, it significantly affects the proliferation and anti-apoptotic capabilities of tumor cells. Therefore, HER3 and IGF1R play complementary and partially overlapping roles in the survival, proliferation, and metabolism of tumor cells. Combined targeted therapy against HER3 and IGF1R using bispecific antibodies can more comprehensively interfere with the biological mechanisms of tumor cells, especially showing greater therapeutic potential for tumors that express both these receptors.

Fig.1 Left: Pathway involving HER3. (Cao, et al., 2017) Right: Pathway involving IGF1R. (Christopoulos, et al., 2015) Fig.1 Left: The function mechanism of HER2-HER3 co-expression.1 Right: Schematic representation of the crosstalk between the IGF-1 system and estrogens in breast cancer. 2

References

  1. Cao, GD.; Chen, K.; et al. Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients. BMC Cancer. 2017, 17(1):841.
  2. Christopoulos, PF.; Msaouel, P.; et al The role of the insulin-like growth factor-1 system in breast cancer. Molecular Cancer. 2015, 14:43.
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