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HIV-1 gp120 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H258 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human HIV-1 gp120 Human Inquiry
T-BSDB-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse HIV-1 gp120 Mouse Inquiry
SCIGG-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human HIV-1 gp120 Human Inquiry
FABVC-379 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse HIV-1 gp120 llama Inquiry
BSSG-379 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (sdAb-IgG) Human sdAb-IgG CD3 Mouse HIV-1 gp120 llama Inquiry
HCAB-024 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb CD3 llama HIV-1 gp120 llama Inquiry
BIBD-379 Recombinant Anti-CD3 x Anti-HIV-1 gp120 VHH BispecificAntibody (Bibody) Human Bibody CD3 Mouse HIV-1 gp120 llama Inquiry
TRIB-378 Recombinant Anti-CD3 x Anti-HIV-1 gp120 VHH Bispecific Antibody (Fab-sdAb-sdAb) Human Fab-sdAb-sdAb CD3 Mouse HIV-1 gp120 llama Inquiry
IGVHH-024 Recombinant Anti-CD3 x Anti-HIV-1 gp120 sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb CD3 Mouse HIV-1 gp120 llama Inquiry
BIVHH-024 Recombinant Anti-CD3 sdAb x Anti-HIV-1 gp120 sdAb Bispecific Antibody (Bi-sdAb) Human Bi-sdAb CD3 llama HIV-1 gp120 llama Inquiry
SCIGG-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse HIV-1 gp120 Mouse Inquiry
FVTIG-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human HIV-1 gp120 Human Inquiry
FVTIG-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSSG-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human HIV-1 gp120 Human Inquiry
BSSG-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse HIV-1 gp120 Mouse Inquiry
IGLFV-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human HIV-1 gp120 Human Inquiry
IGLFV-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSGV-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Human HIV-1 gp120 Human Inquiry
BSGV-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSDG-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human HIV-1 gp120 Human Inquiry
BSDG-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse HIV-1 gp120 Mouse Inquiry
BABFV-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human HIV-1 gp120 Human Inquiry
BABFV-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse HIV-1 gp120 Mouse Inquiry
FABVC-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human HIV-1 gp120 Human Inquiry
FABVC-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse HIV-1 gp120 Mouse Inquiry
SCDBC-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human HIV-1 gp120 Human Inquiry
SCDBC-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSDBC-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human HIV-1 gp120 Human Inquiry
BSDBC-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse HIV-1 gp120 Mouse Inquiry
SCDBF-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human HIV-1 gp120 Human Inquiry
SCDBF-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSFVF-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human HIV-1 gp120 Human Inquiry
BSFVF-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSDBF-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human HIV-1 gp120 Human Inquiry
BSDBF-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSTF-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Human HIV-1 gp120 Human Inquiry
BSTF-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSCFV-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Human HIV-1 gp120 Human Inquiry
BSCFV-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse HIV-1 gp120 Mouse Inquiry
MNAB-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Human HIV-1 gp120 Human Inquiry
MNAB-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSFC-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Human HIV-1 gp120 Human Inquiry
BSFC-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSCC-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Human HIV-1 gp120 Human Inquiry
BSCC-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse HIV-1 gp120 Mouse Inquiry
BIBD-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (Bibody) Human Bibody CD3 Human HIV-1 gp120 Human Inquiry
BIBD-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse HIV-1 gp120 Mouse Inquiry
FABFV-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human HIV-1 gp120 Human Inquiry
FABFV-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse HIV-1 gp120 Mouse Inquiry
MiniB-H260 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp120 Bispecific Antibody (Minibody) Human Minibody CD3 Human HIV-1 gp120 Human Inquiry
MiniB-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse HIV-1 gp120 Mouse Inquiry
SCTB-H155 Recombinant Human Anti-HIV-1 gp120 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human HIV-1 gp120 Human Inquiry
SCDB-H258 Recombinant Human Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human HIV-1 gp120 Human Inquiry
FABIG-H258 Recombinant Human Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human HIV-1 gp120 Human Inquiry
TRIB-H260 Recombinant Human Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human HIV-1 gp120 Human Inquiry
BSIG-H258 Human Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human HIV-1 gp120 Human Inquiry
CROSSAB-H258 Recombinant Human Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human HIV-1 gp120 Human Inquiry
IGFV-H258 Recombinant Human Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human HIV-1 gp120 Human Inquiry
BSDB-H258 Recombinant Human Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Diabody) Human Diabody CD3 Human HIV-1 gp120 Human Inquiry
BSFAB-H258 Recombinant Human Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human HIV-1 gp120 Human Inquiry
BSFV-H258 Recombinant Human Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human HIV-1 gp120 Human Inquiry
SCTB-057 Recombinant Anti-HIV-1 gp120 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse HIV-1 gp120 Mouse Inquiry
SCDB-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse HIV-1 gp120 Mouse Inquiry
FABIG-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse HIV-1 gp120 Mouse Inquiry
TRIB-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSIG-084 Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse HIV-1 gp120 Mouse Inquiry
CROSSAB-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse HIV-1 gp120 Mouse Inquiry
IGFV-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSDB-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSFAB-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse HIV-1 gp120 Mouse Inquiry
BSFV-084 Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse HIV-1 gp120 Mouse Inquiry

Background

HIV-1 envelope glycoprotein gp120 is an instrumental factor that mediates the attachment between the virus and human host cells, initiating a dynamic conformational transformation that is responsive to its host receptor, CD4, and co-receptor.

Initially, gp120 binds to CD4, followed by an interaction with the co-receptor CCR5. This high-affinity interaction subsequently triggers the fusion of the virus and the host cell membrane, facilitating the entry of the viral particles into the host cell. Various studies have also unveiled the crucial role of the interaction between gp120 and CD4 during virus transfer and propagation between cells, mediated by viral synapses.

Furthermore, the trimeric conformational changes of HIV-1 gp120 serve to shield recognition sites, creating a dynamic conformational landscape that not only disrupts the human immune system but also poses challenges for the development of effective therapeutic strategies.

HIV-1 entry and gp120. (Acharya, et al., 2015) Fig.1 HIV-1 entry and gp120.1

Reference

  1. Acharya, Lusvarghi, et al. " HIV-1 gp120 as a therapeutic target: Navigating a moving labyrinth." Expert Opin Ther Targets. 19 6 (2015): 765-783.
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