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HIV-1 gp41 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BSCFV-H261 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp41 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Human HIV-1 gp41 Human Inquiry
BSCFV-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSCFV-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD64 Mouse HIV-1 gp41 Mouse Inquiry
BSCFV-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse HIV-1 gp41 Mouse Inquiry
MNAB-H306 Recombinant Human Anti-CD89 x Human Anti-HIV-1 gp41 Bispecific Antibody (Miniantibody) Human Miniantibody CD89 Human HIV-1 gp41 Human Inquiry
MNAB-H301 Recombinant Human Anti-CD64 x Human Anti-HIV-1 gp41 Bispecific Antibody (Miniantibody) Human Miniantibody CD64 Human HIV-1 gp41 Human Inquiry
MNAB-H261 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp41 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Human HIV-1 gp41 Human Inquiry
MNAB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Miniantibody) Human Miniantibody CD89 Mouse HIV-1 gp41 Mouse Inquiry
MNAB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Miniantibody) Human Miniantibody CD64 Mouse HIV-1 gp41 Mouse Inquiry
MNAB-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse HIV-1 gp41 Mouse Inquiry
BSFC-H306 Recombinant Human Anti-CD89 x Human Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD89 Human HIV-1 gp41 Human Inquiry
BSFC-H301 Recombinant Human Anti-CD64 x Human Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD64 Human HIV-1 gp41 Human Inquiry
BSFC-H261 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Human HIV-1 gp41 Human Inquiry
BSFC-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSFC-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD64 Mouse HIV-1 gp41 Mouse Inquiry
BSFC-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse HIV-1 gp41 Mouse Inquiry
BSCC-H306 Recombinant Human Anti-CD89 x Human Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD89 Human HIV-1 gp41 Human Inquiry
BSCC-H301 Recombinant Human Anti-CD64 x Human Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD64 Human HIV-1 gp41 Human Inquiry
BSCC-H261 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Human HIV-1 gp41 Human Inquiry
BSCC-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSCC-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD64 Mouse HIV-1 gp41 Mouse Inquiry
BSCC-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse HIV-1 gp41 Mouse Inquiry
BIBD-H306 Recombinant Human Anti-CD89 x Human Anti-HIV-1 gp41 Bispecific Antibody (Bibody) Human Bibody CD89 Human HIV-1 gp41 Human Inquiry
BIBD-H301 Recombinant Human Anti-CD64 x Human Anti-HIV-1 gp41 Bispecific Antibody (Bibody) Human Bibody CD64 Human HIV-1 gp41 Human Inquiry
BIBD-H261 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp41 Bispecific Antibody (Bibody) Human Bibody CD3 Human HIV-1 gp41 Human Inquiry
BIBD-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Bibody) Human Bibody CD89 Mouse HIV-1 gp41 Mouse Inquiry
BIBD-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Bibody) Human Bibody CD64 Mouse HIV-1 gp41 Mouse Inquiry
BIBD-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse HIV-1 gp41 Mouse Inquiry
FABFV-H306 Recombinant Human Anti-CD89 x Human Anti-HIV-1 gp41 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD89 Human HIV-1 gp41 Human Inquiry
FABFV-H301 Recombinant Human Anti-CD64 x Human Anti-HIV-1 gp41 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD64 Human HIV-1 gp41 Human Inquiry
FABFV-H261 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp41 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human HIV-1 gp41 Human Inquiry
FABFV-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD89 Mouse HIV-1 gp41 Mouse Inquiry
FABFV-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD64 Mouse HIV-1 gp41 Mouse Inquiry
FABFV-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse HIV-1 gp41 Mouse Inquiry
MiniB-H306 Recombinant Human Anti-CD89 x Human Anti-HIV-1 gp41 Bispecific Antibody (Minibody) Human Minibody CD89 Human HIV-1 gp41 Human Inquiry
MiniB-H301 Recombinant Human Anti-CD64 x Human Anti-HIV-1 gp41 Bispecific Antibody (Minibody) Human Minibody CD64 Human HIV-1 gp41 Human Inquiry
MiniB-H261 Recombinant Human Anti-CD3 x Human Anti-HIV-1 gp41 Bispecific Antibody (Minibody) Human Minibody CD3 Human HIV-1 gp41 Human Inquiry
MiniB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Minibody) Human Minibody CD89 Mouse HIV-1 gp41 Mouse Inquiry
MiniB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Minibody) Human Minibody CD64 Mouse HIV-1 gp41 Mouse Inquiry
MiniB-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse HIV-1 gp41 Mouse Inquiry
SCTB-H195 Recombinant Human Anti-HIV-1 gp41 x Anti-CD89 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody HIV-1 gp41 Human CD89 Human Inquiry
SCTB-H190 Recombinant Human Anti-HIV-1 gp41 x Human Anti-CD64 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD64 Human HIV-1 gp41 Human Inquiry
SCTB-H156 Recombinant Human Anti-HIV-1 gp41 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human HIV-1 gp41 Human Inquiry
SCDB-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD89 Human HIV-1 gp41 Human Inquiry
SCDB-H299 Recombinant Human Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD64 Human HIV-1 gp41 Human Inquiry
SCDB-H259 Recombinant Human Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human HIV-1 gp41 Human Inquiry
FABIG-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD89 Human HIV-1 gp41 Human Inquiry
FABIG-H299 Recombinant Human Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD64 Human HIV-1 gp41 Human Inquiry
FABIG-H259 Recombinant Human Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human HIV-1 gp41 Human Inquiry
TRIB-H306 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD89 Human HIV-1 gp41 Human Inquiry
TRIB-H301 Recombinant Human Anti-CD64 x Human Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD64 Human HIV-1 gp41 Human Inquiry
TRIB-H261 Recombinant Human Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human HIV-1 gp41 Human Inquiry
BSIG-H304 Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD89 Human HIV-1 gp41 Human Inquiry
BSIG-H299 Human Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD64 Human HIV-1 gp41 Human Inquiry
BSIG-H259 Human Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human HIV-1 gp41 Human Inquiry
CROSSAB-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (CrossMab) Human CrossMab CD89 Human HIV-1 gp41 Human Inquiry
CROSSAB-H299 Recombinant Human Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (CrossMab) Human CrossMab CD64 Human HIV-1 gp41 Human Inquiry
CROSSAB-H259 Recombinant Human Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human HIV-1 gp41 Human Inquiry
IGFV-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD89 Human HIV-1 gp41 Human Inquiry
IGFV-H299 Recombinant Human Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD64 Human HIV-1 gp41 Human Inquiry
IGFV-H259 Recombinant Human Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human HIV-1 gp41 Human Inquiry
BSDB-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody) Human Diabody CD89 Human HIV-1 gp41 Human Inquiry
BSDB-H299 Recombinant Human Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody) Human Diabody CD64 Human HIV-1 gp41 Human Inquiry
BSDB-H259 Recombinant Human Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody) Human Diabody CD3 Human HIV-1 gp41 Human Inquiry
BSFAB-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD89 Human HIV-1 gp41 Human Inquiry
BSFAB-H299 Recombinant Human Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD64 Human HIV-1 gp41 Human Inquiry
BSFAB-H259 Recombinant Human Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human HIV-1 gp41 Human Inquiry
BSFV-H304 Recombinant Human Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD89 Human HIV-1 gp41 Human Inquiry
BSFV-H299 Recombinant Human Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD64 Human HIV-1 gp41 Human Inquiry
BSFV-H259 Recombinant Human Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human HIV-1 gp41 Human Inquiry
SCTB-101 Recombinant Anti-HIV-1 gp41 x Anti-CD89 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody HIV-1 gp41 Mouse CD89 Mouse Inquiry
SCTB-095 Recombinant Anti-HIV-1 gp41 x Anti-CD64 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD64 Mouse HIV-1 gp41 Mouse Inquiry
SCTB-058 Recombinant Anti-HIV-1 gp41 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse HIV-1 gp41 Mouse Inquiry
SCDB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD89 Mouse HIV-1 gp41 Mouse Inquiry
SCDB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD64 Mouse HIV-1 gp41 Mouse Inquiry
SCDB-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse HIV-1 gp41 Mouse Inquiry
FABIG-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD89 Mouse HIV-1 gp41 Mouse Inquiry
FABIG-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD64 Mouse HIV-1 gp41 Mouse Inquiry
FABIG-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse HIV-1 gp41 Mouse Inquiry
TRIB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD89 Mouse HIV-1 gp41 Mouse Inquiry
TRIB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD64 Mouse HIV-1 gp41 Mouse Inquiry
TRIB-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse HIV-1 gp41 Mouse Inquiry
BSIG-133 Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSIG-127 Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD64 Mouse HIV-1 gp41 Mouse Inquiry
BSIG-085 Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse HIV-1 gp41 Mouse Inquiry
CROSSAB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (CrossMab) Human CrossMab CD89 Mouse HIV-1 gp41 Mouse Inquiry
CROSSAB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (CrossMab) Human CrossMab CD64 Mouse HIV-1 gp41 Mouse Inquiry
CROSSAB-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse HIV-1 gp41 Mouse Inquiry
IGFV-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD89 Mouse HIV-1 gp41 Mouse Inquiry
IGFV-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD64 Mouse HIV-1 gp41 Mouse Inquiry
IGFV-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse HIV-1 gp41 Mouse Inquiry
BSDB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody) Human Diabody CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSDB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody) Human Diabody CD64 Mouse HIV-1 gp41 Mouse Inquiry
BSDB-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse HIV-1 gp41 Mouse Inquiry
BSFAB-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSFAB-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD64 Mouse HIV-1 gp41 Mouse Inquiry
BSFAB-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse HIV-1 gp41 Mouse Inquiry
BSFV-133 Recombinant Anti-CD89 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD89 Mouse HIV-1 gp41 Mouse Inquiry
BSFV-127 Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD64 Mouse HIV-1 gp41 Mouse Inquiry
BSFV-085 Recombinant Anti-CD3 x Anti-HIV-1 gp41 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse HIV-1 gp41 Mouse Inquiry

Background

The HIV-1 envelope glycoprotein, gp41, is an essential constituent that facilitates the viral particle attachment and infection of susceptible cells. Gp41 is structured into three distinct domains: extracellular, transmembrane, and cytoplasmic. The extracellular domain comprises both the C-terminal heptad repeat (CHR) and N-terminal heptad repeat (NHR) sequences, responsible for membrane fusion.

Following HIV-1 infection, the gp41 conformational shift is instigated by the engagement of gp120 with primary receptor CD4 or co-receptor. Upon the fusion peptide's insertion into the cell membrane, three CHR molecules eccentrically insert into the hydrophobic deep groove on the surface of the NHR trimer, culminating in the formation of a stable six-helix bundle (6-HB) core, which ensures the tight binding and fusion of the viral envelope to the target cell membrane. Present research has been leveraging the targeting of gp41 and hindrance of 6-HB structure formation as a principal approach for intervening in HIV-1 infection.

HIV-1 gp41 fusion intermediate. (Pan, et al., 2010) Fig.1 HIV-1 gp41 fusion intermediate.1

Reference

  1. Pan, Liu, et al. " HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics." Journal of the Formosan Medical Association. 109 2 (2010): 94.
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