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HN Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BSDG-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse HN Mouse Inquiry
BSDG-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Fv-IgG) Human Fv-IgG CD28 Mouse HN Mouse Inquiry
BABFV-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human HN Human Inquiry
BABFV-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD28 Human HN Human Inquiry
BABFV-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse HN Mouse Inquiry
BABFV-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD28 Mouse HN Mouse Inquiry
FABVC-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human HN Human Inquiry
FABVC-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD28 Human HN Human Inquiry
FABVC-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse HN Mouse Inquiry
FABVC-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD28 Mouse HN Mouse Inquiry
SCDBC-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human HN Human Inquiry
SCDBC-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD28 Human HN Human Inquiry
SCDBC-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse HN Mouse Inquiry
SCDBC-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD28 Mouse HN Mouse Inquiry
BSDBC-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human HN Human Inquiry
BSDBC-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD28 Human HN Human Inquiry
BSDBC-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse HN Mouse Inquiry
BSDBC-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD28 Mouse HN Mouse Inquiry
SCDBF-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human HN Human Inquiry
SCDBF-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD28 Human HN Human Inquiry
SCDBF-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse HN Mouse Inquiry
SCDBF-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD28 Mouse HN Mouse Inquiry
BSFVF-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human HN Human Inquiry
BSFVF-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD28 Human HN Human Inquiry
BSFVF-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse HN Mouse Inquiry
BSFVF-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD28 Mouse HN Mouse Inquiry
BSDBF-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human HN Human Inquiry
BSDBF-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD28 Human HN Human Inquiry
BSDBF-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse HN Mouse Inquiry
BSDBF-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD28 Mouse HN Mouse Inquiry
BSTF-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse HN Mouse Inquiry
BSTF-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD28 Mouse HN Mouse Inquiry
BSTF-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse HN Mouse Inquiry
BSTF-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD28 Mouse HN Mouse Inquiry
BSCFV-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse HN Mouse Inquiry
BSCFV-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (scFv-Fc) Human scFv-Fc CD28 Mouse HN Mouse Inquiry
BSCFV-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse HN Mouse Inquiry
BSCFV-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (scFv-Fc) Human scFv-Fc CD28 Mouse HN Mouse Inquiry
MNAB-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse HN Mouse Inquiry
MNAB-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (Miniantibody) Human Miniantibody CD28 Mouse HN Mouse Inquiry
MNAB-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse HN Mouse Inquiry
MNAB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Miniantibody) Human Miniantibody CD28 Mouse HN Mouse Inquiry
BSFC-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse HN Mouse Inquiry
BSFC-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD28 Mouse HN Mouse Inquiry
BSFC-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse HN Mouse Inquiry
BSFC-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD28 Mouse HN Mouse Inquiry
BSCC-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse HN Mouse Inquiry
BSCC-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD28 Mouse HN Mouse Inquiry
BSCC-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse HN Mouse Inquiry
BSCC-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD28 Mouse HN Mouse Inquiry
BIBD-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (Bibody) Human Bibody CD3 Mouse HN Mouse Inquiry
BIBD-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (Bibody) Human Bibody CD28 Mouse HN Mouse Inquiry
BIBD-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Bibody) Human Bibody CD3 Mouse HN Mouse Inquiry
BIBD-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Bibody) Human Bibody CD28 Mouse HN Mouse Inquiry
FABFV-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human HN Human Inquiry
FABFV-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 Human HN Human Inquiry
FABFV-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse HN Mouse Inquiry
FABFV-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 Mouse HN Mouse Inquiry
MiniB-H267 Recombinant Human Anti-CD3 x Human Anti-HN Bispecific Antibody (Minibody) Human Minibody CD3 Human HN Human Inquiry
MiniB-H237 Recombinant Human Anti-CD28 x Human Anti-HN Bispecific Antibody (Minibody) Human Minibody CD28 Human HN Human Inquiry
MiniB-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Minibody) Human Minibody CD3 Mouse HN Mouse Inquiry
MiniB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Minibody) Human Minibody CD28 Mouse HN Mouse Inquiry
SCDB-H265 Recombinant Human Anti-CD3 x Anti-HN Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human HN Human Inquiry
SCDB-H235 Recombinant Human Anti-CD28 x Anti-HN Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Human HN Human Inquiry
FABIG-H265 Recombinant Human Anti-CD3 x Anti-HN Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human HN Human Inquiry
FABIG-H235 Recombinant Human Anti-CD28 x Anti-HN Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Human HN Human Inquiry
TRIB-H267 Recombinant Human Anti-CD3 x Anti-HN Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human HN Human Inquiry
TRIB-H237 Recombinant Human Anti-CD28 x Anti-HN Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Human HN Human Inquiry
BSIG-H265 Human Anti-CD3 x Anti-HN Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human HN Human Inquiry
BSIG-H235 Human Anti-CD28 x Anti-HN Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Human HN Human Inquiry
CROSSAB-H265 Recombinant Human Anti-CD3 x Anti-HN Bispecific Antibody (CrossMab) Human CrossMab CD3 Human HN Human Inquiry
CROSSAB-H235 Recombinant Human Anti-CD28 x Anti-HN Bispecific Antibody (CrossMab) Human CrossMab CD28 Human HN Human Inquiry
IGFV-H265 Recombinant Human Anti-CD3 x Anti-HN Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human HN Human Inquiry
IGFV-H235 Recombinant Human Anti-CD28 x Anti-HN Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Human HN Human Inquiry
BSDB-H265 Recombinant Human Anti-CD3 x Anti-HN Bispecific Antibody (Diabody) Human Diabody CD3 Human HN Human Inquiry
BSDB-H235 Recombinant Human Anti-CD28 x Anti-HN Bispecific Antibody (Diabody) Human Diabody CD28 Human HN Human Inquiry
BSFAB-H265 Recombinant Human Anti-CD3 x Anti-HN Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human HN Human Inquiry
BSFAB-H235 Recombinant Human Anti-CD28 x Anti-HN Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Human HN Human Inquiry
BSFV-H265 Recombinant Human Anti-CD3 x Anti-HN Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human HN Human Inquiry
BSFV-H235 Recombinant Human Anti-CD28 x Anti-HN Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Human HN Human Inquiry
SCTB-064 Recombinant Anti-HN x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse HN Mouse Inquiry
SCTB-033 Recombinant Anti-HN x Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Mouse HN Mouse Inquiry
SCDB-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse HN Mouse Inquiry
SCDB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Mouse HN Mouse Inquiry
FABIG-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse HN Mouse Inquiry
FABIG-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse HN Mouse Inquiry
TRIB-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse HN Mouse Inquiry
TRIB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse HN Mouse Inquiry
BSIG-091 Anti-CD3 x Anti-HN Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse HN Mouse Inquiry
BSIG-061 Anti-CD28 x Anti-HN Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse HN Mouse Inquiry
CROSSAB-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse HN Mouse Inquiry
CROSSAB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse HN Mouse Inquiry
IGFV-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse HN Mouse Inquiry
IGFV-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse HN Mouse Inquiry
BSDB-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Diabody) Human Diabody CD3 Mouse HN Mouse Inquiry
BSDB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Diabody) Human Diabody CD28 Mouse HN Mouse Inquiry
BSFAB-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse HN Mouse Inquiry
BSFAB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse HN Mouse Inquiry
BSFV-091 Recombinant Anti-CD3 x Anti-HN Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse HN Mouse Inquiry
BSFV-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse HN Mouse Inquiry

Background

Humanin (HN) is a 24-amino acid peptide encoded by mitochondrial 16S rRNA. HN was discovered as a neuroprotective factor that specifically antagonizes AD-relevant insults. It has been evaluated as a therapeutic target for different chronic diseases. Later, it was noticed that HN regulates many pathways, including apoptosis in several diseases like growth hormone, cancer, and brain-related diseases. HN becomes an attractive candidate due to many biological progressions, including anti-apoptosis, cell stress response inflammation, and substrate metabolism. HN exhibits protective effects in several cell types, including leukocytes, germ cells, neurons, and tissues against cellular stress conditions and apoptosis through regulating various signaling mechanisms, such as the JAK/STAT pathway and interaction of BCL-2 family of proteins. It was found to protect against neuronal apoptotic insult, specifically against amyloid-b toxicity and several familial disease-causing mutations. This protein has been shown to play a role in preventing cell death among various tissues outside of the nervous system as well. One of the mechanisms by which HN exerts its action is through binding to its membrane trimeric receptor.

Fig.1 Mechanism of action of mitochondrial peptide Humanin (HN). (Zuccato, 2019) Fig.1 Mechanism of action of mitochondrial peptide Humanin (HN).1

Reference

  1. Zuccato, Camila Florencia, et al. "Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases." Expert opinion on therapeutic targets 23.2 (2019): 117-126.
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