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IL1α Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H341 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL1α Human IL1β Human Inquiry
T-BSDB-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL1α Mouse IL1β Mouse Inquiry
SCIGG-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scIgG) Human Single chain IgGs IL1α Human IL1β Human Inquiry
SCIGG-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scIgG) Human Single chain IgGs IL1α Mouse IL1β Mouse Inquiry
FVTIG-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL1α Human IL1β Human Inquiry
FVTIG-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL1α Mouse IL1β Mouse Inquiry
BSSG-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scFv-IgG) Human scFv-IgG IL1α Human IL1β Human Inquiry
BSSG-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scFv-IgG) Human scFv-IgG IL1α Mouse IL1β Mouse Inquiry
IGLFV-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL1α Human IL1β Human Inquiry
IGLFV-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL1α Mouse IL1β Mouse Inquiry
BSGV-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (IgG-Fv) Human IgG-Fv IL1α Human IL1β Human Inquiry
BSGV-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (IgG-Fv) Human IgG-Fv IL1α Mouse IL1β Mouse Inquiry
BSDG-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (Fv-IgG) Human Fv-IgG IL1α Human IL1β Human Inquiry
BSDG-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Fv-IgG) Human Fv-IgG IL1α Mouse IL1β Mouse Inquiry
BABFV-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL1α Human IL1β Human Inquiry
BABFV-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL1α Mouse IL1β Mouse Inquiry
FABVC-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL1α Human IL1β Human Inquiry
FABVC-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL1α Mouse IL1β Mouse Inquiry
SCDBC-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL1α Human IL1β Human Inquiry
SCDBC-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL1α Mouse IL1β Mouse Inquiry
BSDBC-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL1α Human IL1β Human Inquiry
BSDBC-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL1α Mouse IL1β Mouse Inquiry
SCDBF-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL1α Human IL1β Human Inquiry
SCDBF-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL1α Mouse IL1β Mouse Inquiry
BSFVF-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL1α Human IL1β Human Inquiry
BSFVF-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL1α Mouse IL1β Mouse Inquiry
BSDBF-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL1α Human IL1β Human Inquiry
BSDBF-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL1α Mouse IL1β Mouse Inquiry
BSTF-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL1α Human IL1β Human Inquiry
BSTF-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL1α Mouse IL1β Mouse Inquiry
BSCFV-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scFv-Fc) Human scFv-Fc IL1α Human IL1β Human Inquiry
BSCFV-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scFv-Fc) Human scFv-Fc IL1α Mouse IL1β Mouse Inquiry
MNAB-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (Miniantibody) Human Miniantibody IL1α Human IL1β Human Inquiry
MNAB-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Miniantibody) Human Miniantibody IL1α Mouse IL1β Mouse Inquiry
BSFC-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL1α Human IL1β Human Inquiry
BSFC-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL1α Mouse IL1β Mouse Inquiry
BSCC-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL1α Human IL1β Human Inquiry
BSCC-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL1α Mouse IL1β Mouse Inquiry
BIBD-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (Bibody) Human Bibody IL1α Human IL1β Human Inquiry
BIBD-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Bibody) Human Bibody IL1α Mouse IL1β Mouse Inquiry
FABFV-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (Fab-Fv) Human Fab-Fv IL1α Human IL1β Human Inquiry
FABFV-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Fab-Fv) Human Fab-Fv IL1α Mouse IL1β Mouse Inquiry
MiniB-H342 Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (Minibody) Human Minibody IL1α Human IL1β Human Inquiry
MiniB-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Minibody) Human Minibody IL1α Mouse IL1β Mouse Inquiry
SCDB-H341 Recombinant Human Anti-IL1α x Anti-IL1β Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL1α Human IL1β Human Inquiry
FABIG-H341 Recombinant Human Anti-IL1α x Anti-IL1β Bispecific Antibody (Fab-IgG) Human Fab-IgG IL1α Human IL1β Human Inquiry
TRIB-H343 Recombinant Human Anti-IL1α x Anti-IL1β Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL1α Human IL1β Human Inquiry
BSIG-H341 Human Anti-IL1α x Anti-IL1β Bispecific Antibody (IgG-IgG) Human IgG-IgG IL1α Human IL1β Human Inquiry
CROSSAB-H341 Recombinant Human Anti-IL1α x Anti-IL1β Bispecific Antibody (CrossMab) Human CrossMab IL1α Human IL1β Human Inquiry
IGFV-H341 Recombinant Human Anti-IL1α x Anti-IL1β Bispecific Antibody (IgG-scFv) Human IgG-scFv IL1α Human IL1β Human Inquiry
BSDB-H341 Recombinant Human Anti-IL1α x Anti-IL1β Bispecific Antibody (Diabody) Human Diabody IL1α Human IL1β Human Inquiry
BSFAB-H341 Recombinant Human Anti-IL1α x Anti-IL1β Bispecific Antibody (Tandem Fab) Human Tandem Fab IL1α Human IL1β Human Inquiry
BSFV-H339 Recombinant Human Anti-IL1α x Anti-IL1β Bispecific Antibody (Tandem scFv) Human Tandem scFv IL1α Human IL1β Human Inquiry
SCDB-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL1α Mouse IL1β Mouse Inquiry
FABIG-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Fab-IgG) Human Fab-IgG IL1α Mouse IL1β Mouse Inquiry
TRIB-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL1α Mouse IL1β Mouse Inquiry
BSIG-177 Anti-IL1α x Anti-IL1β Bispecific Antibody (IgG-IgG) Human IgG-IgG IL1α Mouse IL1β Mouse Inquiry
CROSSAB-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (CrossMab) Human CrossMab IL1α Mouse IL1β Mouse Inquiry
IGFV-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (IgG-scFv) Human IgG-scFv IL1α Mouse IL1β Mouse Inquiry
BSDB-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Diabody) Human Diabody IL1α Mouse IL1β Mouse Inquiry
BSFAB-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Tandem Fab) Human Tandem Fab IL1α Mouse IL1β Mouse Inquiry
BSFV-177 Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (Tandem scFv) Human Tandem scFv IL1α Mouse IL1β Mouse Inquiry

Background

The IL-1-driven inflammatory loop. (Cavalli, et al., 2021)Fig.1 The IL-1-driven inflammatory loop.1

IL-1α, a pro-inflammatory cytokine and a member of the interleukin-1 family, plays a crucial role in immune responses and inflammation regulation. It is generated by many kinds of cells including monocytes, epithelial cells, and macrophages. By binding to its specific receptor, IL1R, IL1α triggers intracellular signaling cascades that activate transcription factors and gene expression. IL1α can help in the defense against infections by encouraging the immune cells to recruit and mentactivation. Moreover, it promotes wound healing, tissue regeneration, and angiogenesis. On the other hand, dysregulated IL1α activity has been connected to cancer, autoimmune diseases, and chronic inflammation. Many fields are investigating the potential of IL1α modulation as a therapeutic strategy. Targeting IL1 signaling, for example, has shown promise in the treatment of inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis. Furthermore, IL1α-based immunotherapies are being investigated as potential anti-cancer strategies due to their role in tumor progression and immune evasion.

Reference

  1. Cavalli, Giulio, et al. “Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases.” Autoimmunity reviews vol. 20,3 (2021).
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