IL12 (Interleukin 12) is a 70 kDa heterodimeric cytokine that consists of covalently linked p35 and p40 chains. It belongs to the IL-12 family of heterodimeric cytokines, also including IL-23, IL-27, and IL-35. IL-12 is mostly produced by phagocytic cells (e.g. stimulated macrophages and neutrophils) in response to bacteria, bacterial products and intracellular parasites, and to some extent by B cells. It is essential for skewing the immunity response towards a T helper 1 (Th1) of cytokine profile. Il-12 can induce cytokine production from natural killer (NK) and T cells, primarily of interferon-gamma (IFN-γ). It functions as a critical growth factor for activated NK and T cells that can enhance the cytotoxic activity of NK cells and benefits T lymphocyte cytotoxic generation. IL18 (Interleukin 18), similar to IL-1β, is classified in the IL-1 family of cytokines. IL-18 is also referred as interferon-gamma inducing factor and first synthesized as an inactive precursor, which requires processing into an active cytokine by caspase-1. Stimulation of IL-18 acts as a pro-inflammatory cytokine by inducing cytokine called interferon-γ (IFN-γ) and type II interferon production, contributing to activating the macrophages or other cells. Together with IL-12, IL-18 binds to the interleukin-18 receptor induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). In addition, IL-18 is capable to induce severe inflammatory reactions and plays an important role in some inflammatory disorders diseases.