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IL12 & IL18 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H335 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL12 Human IL18 Human Inquiry
T-BSDB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL12 Mouse IL18 Mouse Inquiry
SCIGG-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scIgG) Human Single chain IgGs IL12 Human IL18 Human Inquiry
SCIGG-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scIgG) Human Single chain IgGs IL12 Mouse IL18 Mouse Inquiry
FVTIG-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL12 Human IL18 Human Inquiry
FVTIG-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL12 Mouse IL18 Mouse Inquiry
BSSG-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-IgG) Human scFv-IgG IL12 Human IL18 Human Inquiry
BSSG-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-IgG) Human scFv-IgG IL12 Mouse IL18 Mouse Inquiry
IGLFV-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL12 Human IL18 Human Inquiry
IGLFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL12 Mouse IL18 Mouse Inquiry
BSGV-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL12 Mouse IL18 Mouse Inquiry
BSGV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL12 Mouse IL18 Mouse Inquiry
BSDG-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL12 Human IL18 Human Inquiry
BSDG-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL12 Mouse IL18 Mouse Inquiry
BABFV-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL12 Human IL18 Human Inquiry
BABFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL12 Mouse IL18 Mouse Inquiry
FABVC-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL12 Human IL18 Human Inquiry
FABVC-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL12 Mouse IL18 Mouse Inquiry
SCDBC-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL12 Human IL18 Human Inquiry
SCDBC-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL12 Mouse IL18 Mouse Inquiry
BSDBC-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL12 Human IL18 Human Inquiry
BSDBC-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL12 Mouse IL18 Mouse Inquiry
SCDBF-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL12 Human IL18 Human Inquiry
SCDBF-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL12 Mouse IL18 Mouse Inquiry
BSFVF-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL12 Human IL18 Human Inquiry
BSFVF-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL12 Mouse IL18 Mouse Inquiry
BSDBF-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL12 Human IL18 Human Inquiry
BSDBF-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL12 Mouse IL18 Mouse Inquiry
BSTF-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL12 Mouse IL18 Mouse Inquiry
BSTF-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL12 Mouse IL18 Mouse Inquiry
BSCFV-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL12 Mouse IL18 Mouse Inquiry
BSCFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL12 Mouse IL18 Mouse Inquiry
MNAB-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Miniantibody) Human Miniantibody IL12 Mouse IL18 Mouse Inquiry
MNAB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Miniantibody) Human Miniantibody IL12 Mouse IL18 Mouse Inquiry
BSFC-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL12 Mouse IL18 Mouse Inquiry
BSFC-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL12 Mouse IL18 Mouse Inquiry
BSCC-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL12 Mouse IL18 Mouse Inquiry
BSCC-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL12 Mouse IL18 Mouse Inquiry
BIBD-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Bibody) Human Bibody IL12 Mouse IL18 Mouse Inquiry
BIBD-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Bibody) Human Bibody IL12 Mouse IL18 Mouse Inquiry
FABFV-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL12 Human IL18 Human Inquiry
FABFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL12 Mouse IL18 Mouse Inquiry
MiniB-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Minibody) Human Minibody IL12 Human IL18 Human Inquiry
MiniB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Minibody) Human Minibody IL12 Mouse IL18 Mouse Inquiry
SCDB-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL12 Human IL18 Human Inquiry
FABIG-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL12 Human IL18 Human Inquiry
TRIB-H337 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL12 Human IL18 Human Inquiry
BSIG-H335 Human Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL12 Human IL18 Human Inquiry
CROSSAB-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (CrossMab) Human CrossMab IL12 Human IL18 Human Inquiry
IGFV-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL12 Human IL18 Human Inquiry
BSDB-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Diabody) Human Diabody IL12 Human IL18 Human Inquiry
BSFAB-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL12 Human IL18 Human Inquiry
BSFV-H333 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL12 Human IL18 Human Inquiry
SCDB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL12 Mouse IL18 Mouse Inquiry
FABIG-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL12 Mouse IL18 Mouse Inquiry
TRIB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL12 Mouse IL18 Mouse Inquiry
BSIG-171 Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL12 Mouse IL18 Mouse Inquiry
CROSSAB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (CrossMab) Human CrossMab IL12 Mouse IL18 Mouse Inquiry
IGFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL12 Mouse IL18 Mouse Inquiry
BSDB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Diabody) Human Diabody IL12 Mouse IL18 Mouse Inquiry
BSFAB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL12 Mouse IL18 Mouse Inquiry
BSFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL12 Mouse IL18 Mouse Inquiry

Background

IL12 (Interleukin 12) and IL18 (Interleukin 18) play crucial roles in immune regulation, significantly enhancing the Th1 immune response through their synergistic mechanisms. The primary function of IL12 is to activate T cells and Natural Killer (NK) cells, prompting them to produce a large amount of Interferon-gamma, a powerful immune-regulating factor. IL18, on the other hand, plays a complementary role in stimulating the production of Interferon-gamma, acting through molecular pathways distinct from IL12. This interaction not only strengthens the cell-mediated immune response but also enhances resistance to pathogens. This synergistic effect provides a new strategy for treating some challenging diseases. Particularly in combating tumors and certain persistent infectious diseases, the combined targeting of IL12 and IL18 has shown significant potential. By targeting these two cytokines with anti-IL12&IL18 bispecific antibodies, the immune system can be activated more effectively, resulting in a stronger and more sustained immune response.

Fig.1 IL-12 and IL-18 are involved in T-cell responses.. (Nakanishi, et al., 2001) Fig.1 IL-18 stimulates Th1 or Th2 response depending on its cytokine milieu.1

Reference

  1. Nakanishi, K.; et al. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine & Growth Factor Reviews. 2001,12(1):53-72.
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