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IL12 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H335 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL12 Human IL18 Human Inquiry
T-BSDB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL12 Mouse IL18 Mouse Inquiry
SCIGG-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scIgG) Human Single chain IgGs IL12 Human IL18 Human Inquiry
SCIGG-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scIgG) Human Single chain IgGs IL12 Mouse IL18 Mouse Inquiry
FVTIG-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL12 Human IL18 Human Inquiry
FVTIG-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL12 Mouse IL18 Mouse Inquiry
BSSG-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-IgG) Human scFv-IgG IL12 Human IL18 Human Inquiry
BSSG-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-IgG) Human scFv-IgG IL12 Mouse IL18 Mouse Inquiry
IGLFV-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL12 Human IL18 Human Inquiry
IGLFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL12 Mouse IL18 Mouse Inquiry
BSGV-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL12 Mouse IL18 Mouse Inquiry
BSGV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL12 Mouse IL18 Mouse Inquiry
BSDG-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL12 Human IL18 Human Inquiry
BSDG-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL12 Mouse IL18 Mouse Inquiry
BABFV-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL12 Human IL18 Human Inquiry
BABFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL12 Mouse IL18 Mouse Inquiry
FABVC-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL12 Human IL18 Human Inquiry
FABVC-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL12 Mouse IL18 Mouse Inquiry
SCDBC-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL12 Human IL18 Human Inquiry
SCDBC-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL12 Mouse IL18 Mouse Inquiry
BSDBC-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL12 Human IL18 Human Inquiry
BSDBC-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL12 Mouse IL18 Mouse Inquiry
SCDBF-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL12 Human IL18 Human Inquiry
SCDBF-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL12 Mouse IL18 Mouse Inquiry
BSFVF-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL12 Human IL18 Human Inquiry
BSFVF-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL12 Mouse IL18 Mouse Inquiry
BSDBF-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL12 Human IL18 Human Inquiry
BSDBF-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL12 Mouse IL18 Mouse Inquiry
BSTF-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL12 Mouse IL18 Mouse Inquiry
BSTF-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL12 Mouse IL18 Mouse Inquiry
BSCFV-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL12 Mouse IL18 Mouse Inquiry
BSCFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL12 Mouse IL18 Mouse Inquiry
MNAB-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Miniantibody) Human Miniantibody IL12 Mouse IL18 Mouse Inquiry
MNAB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Miniantibody) Human Miniantibody IL12 Mouse IL18 Mouse Inquiry
BSFC-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL12 Mouse IL18 Mouse Inquiry
BSFC-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL12 Mouse IL18 Mouse Inquiry
BSCC-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL12 Mouse IL18 Mouse Inquiry
BSCC-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL12 Mouse IL18 Mouse Inquiry
BIBD-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Bibody) Human Bibody IL12 Mouse IL18 Mouse Inquiry
BIBD-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Bibody) Human Bibody IL12 Mouse IL18 Mouse Inquiry
FABFV-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL12 Human IL18 Human Inquiry
FABFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL12 Mouse IL18 Mouse Inquiry
MiniB-H336 Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Minibody) Human Minibody IL12 Human IL18 Human Inquiry
MiniB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Minibody) Human Minibody IL12 Mouse IL18 Mouse Inquiry
SCDB-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL12 Human IL18 Human Inquiry
FABIG-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL12 Human IL18 Human Inquiry
TRIB-H337 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL12 Human IL18 Human Inquiry
BSIG-H335 Human Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL12 Human IL18 Human Inquiry
CROSSAB-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (CrossMab) Human CrossMab IL12 Human IL18 Human Inquiry
IGFV-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL12 Human IL18 Human Inquiry
BSDB-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Diabody) Human Diabody IL12 Human IL18 Human Inquiry
BSFAB-H335 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL12 Human IL18 Human Inquiry
BSFV-H333 Recombinant Human Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL12 Human IL18 Human Inquiry
SCDB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL12 Mouse IL18 Mouse Inquiry
FABIG-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL12 Mouse IL18 Mouse Inquiry
TRIB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL12 Mouse IL18 Mouse Inquiry
BSIG-171 Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL12 Mouse IL18 Mouse Inquiry
CROSSAB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (CrossMab) Human CrossMab IL12 Mouse IL18 Mouse Inquiry
IGFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL12 Mouse IL18 Mouse Inquiry
BSDB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Diabody) Human Diabody IL12 Mouse IL18 Mouse Inquiry
BSFAB-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL12 Mouse IL18 Mouse Inquiry
BSFV-171 Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL12 Mouse IL18 Mouse Inquiry

Background

Interleukin 12 (IL-12) is a cytokine inherently secreted by macrophages, human B-lymphoblastoid cells, dendritic cells, and neutrophils in response to antigenic stimulation. As a member of the interleukin-12 family, which encompasses cytokines with various functions, IL-12 is recognized as a T cell-stimulating factor that can promote the differentiation, growth, and function of T cells, it also plays a role in enhancing the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. IL-12 has attracted attention for its potential as an anti-cancer drug, attributed to its capacity to induce immune responses and demonstrate anti-angiogenic activity. However, its substantial efficacy in tested tumors remains unproven to date. Additionally, there is a potential therapeutic link between IL-12 and diseases such as psoriasis and inflammatory bowel disease.

IL-12 binding receptor and related signal transduction. (Trinchieri, et al., 2003) Fig.1 IL-12 binding receptor and related signal transduction.1

Reference

  1. Trinchieri, Giorgio. "Interleukin-12 and the regulation of innate resistance and adaptive immunity." Nature Reviews Immunology 3.2 (2003): 133-146.
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