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IL17 & IL23 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem Diabody) Human IL17 IL23 Inquiry
T-BSDB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem Diabody) Human IL17 IL23 Inquiry
SCIGG-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scIgG) Human Single chain IgGs IL17 IL23 Inquiry
SCIGG-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scIgG) Human Single chain IgGs IL17 IL23 Inquiry
FVTIG-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv4-Ig) Human Appended IgGs IL17 IL23 Inquiry
FVTIG-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv4-Ig) Human Appended IgGs IL17 IL23 Inquiry
BSSG-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-IgG) Human Appended IgGs IL17 IL23 Inquiry
BSSG-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-IgG) Human Appended IgGs IL17 IL23 Inquiry
IGLFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs IL17 IL23 Inquiry
IGLFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs IL17 IL23 Inquiry
BSGV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL17 IL23 Inquiry
BSGV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL17 IL23 Inquiry
BSDG-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Fv-IgG) Human Appended IgGs IL17 IL23 Inquiry
BSDG-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fv-IgG) Human Appended IgGs IL17 IL23 Inquiry
BABFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins IL17 IL23 Inquiry
BABFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins IL17 IL23 Inquiry
FABVC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins IL17 IL23 Inquiry
FABVC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins IL17 IL23 Inquiry
SCDBC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments IL17 IL23 Inquiry
SCDBC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments IL17 IL23 Inquiry
BSDBC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments IL17 IL23 Inquiry
BSDBC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments IL17 IL23 Inquiry
SCDBF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments IL17 IL23 Inquiry
SCDBF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments IL17 IL23 Inquiry
BSFVF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments IL17 IL23 Inquiry
BSFVF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments IL17 IL23 Inquiry
BSDBF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments IL17 IL23 Inquiry
BSDBF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments IL17 IL23 Inquiry
BSTF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments IL17 IL23 Inquiry
BSTF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments IL17 IL23 Inquiry
BSCFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments IL17 IL23 Inquiry
BSCFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments IL17 IL23 Inquiry
MNAB-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments IL17 IL23 Inquiry
MNAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments IL17 IL23 Inquiry
BSFC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments IL17 IL23 Inquiry
BSFC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments IL17 IL23 Inquiry
BSCC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments IL17 IL23 Inquiry
BSCC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments IL17 IL23 Inquiry
BIBD-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Bibody) Human Bibody IL17 IL23 Inquiry
BIBD-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Bibody) Human Bibody IL17 IL23 Inquiry
FABFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 IL23 Inquiry
FABFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 IL23 Inquiry
MiniB-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Minibody) Human Minibody IL17 IL23 Inquiry
MiniB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Minibody) Human Minibody IL17 IL23 Inquiry
SCDB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 IL23 Inquiry
FABIG-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 IL23 Inquiry
TRIB-H340 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Triple Body) Human Triple Body IL17 IL23 Inquiry
BSIG-H338 Human Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 IL23 Inquiry
CROSSAB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (CrossMab) Human CrossMab IL17 IL23 Inquiry
IGFV-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 IL23 Inquiry
BSDB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody) Human Diabody IL17 IL23 Inquiry
BSFAB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 IL23 Inquiry
BSFV-H336 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 IL23 Inquiry
SCDB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 IL23 Inquiry
FABIG-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 IL23 Inquiry
TRIB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Triple Body) Human Triple Body IL17 IL23 Inquiry
BSIG-174 Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 IL23 Inquiry
CROSSAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (CrossMab) Human CrossMab IL17 IL23 Inquiry
IGFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 IL23 Inquiry
BSDB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody) Human Diabody IL17 IL23 Inquiry
BSFAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 IL23 Inquiry
BSFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 IL23 Inquiry
MiniB-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Minibody) Human Minibody IL23 IL6 Inquiry
MiniB-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 TNF Inquiry
MiniB-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Minibody) Human Minibody IL13 IL17 Inquiry
MiniB-H199 Recombinant Human Anti-BAFF x Human Anti-IL17 Bispecific Antibody (Minibody) Human Minibody BAFF IL17 Inquiry
MiniB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Minibody) Human Minibody IL23 IL6 Inquiry
MiniB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 TNF Inquiry
MiniB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Minibody) Human Minibody IL13 IL17 Inquiry
MiniB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Minibody) Human Minibody BAFF IL17 Inquiry
SCDB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL23 IL6 Inquiry
SCDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 TNF Inquiry
SCDB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL13 IL17 Inquiry
SCDB-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody BAFF IL17 Inquiry
FABIG-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL23 IL6 Inquiry
FABIG-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 TNF Inquiry
FABIG-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL13 IL17 Inquiry
FABIG-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Fab-IgG) Human Fab-IgG BAFF IL17 Inquiry
TRIB-H344 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Triple Body) Human Triple Body IL23 IL6 Inquiry
TRIB-H341 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body IL17 TNF Inquiry
TRIB-H338 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Triple Body) Human Triple Body IL13 IL17 Inquiry
TRIB-H199 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Triple Body) Human Triple Body BAFF IL17 Inquiry
BSIG-H342 Human Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL23 IL6 Inquiry
BSIG-H339 Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 TNF Inquiry
BSIG-H336 Human Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL13 IL17 Inquiry
BSIG-H197 Human Anti-BAFF x Anti-IL17 Bispecific Antibody (IgG-IgG) Human IgG-IgG BAFF IL17 Inquiry
CROSSAB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (CrossMab) Human CrossMab IL23 IL6 Inquiry
CROSSAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 TNF Inquiry
CROSSAB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (CrossMab) Human CrossMab IL13 IL17 Inquiry
CROSSAB-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (CrossMab) Human CrossMab BAFF IL17 Inquiry
IGFV-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL23 IL6 Inquiry
IGFV-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 TNF Inquiry
IGFV-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL13 IL17 Inquiry
IGFV-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (IgG-scFv) Human IgG-scFv BAFF IL17 Inquiry
BSDB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody) Human Diabody IL23 IL6 Inquiry
BSDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 TNF Inquiry
BSDB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Diabody) Human Diabody IL13 IL17 Inquiry
BSDB-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Diabody) Human Diabody BAFF IL17 Inquiry
BSFAB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL23 IL6 Inquiry
BSFAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 TNF Inquiry
BSFAB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL13 IL17 Inquiry
BSFAB-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Tandem Fab) Human Tandem Fab BAFF IL17 Inquiry
BSFV-H340 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL23 IL6 Inquiry
BSFV-H337 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 TNF Inquiry
BSFV-H334 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL13 IL17 Inquiry
BSFV-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Tandem scFv) Human Tandem scFv BAFF IL17 Inquiry
SCDB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL23 IL6 Inquiry
SCDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 TNF Inquiry
SCDB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL13 IL17 Inquiry
SCDB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody BAFF IL17 Inquiry
FABIG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL23 IL6 Inquiry
FABIG-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 TNF Inquiry
FABIG-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL13 IL17 Inquiry
FABIG-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Fab-IgG) Human Fab-IgG BAFF IL17 Inquiry
TRIB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Triple Body) Human Triple Body IL23 IL6 Inquiry
TRIB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Triple Body) Human Triple Body IL17 TNF Inquiry
TRIB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Triple Body) Human Triple Body IL13 IL17 Inquiry
TRIB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Triple Body) Human Triple Body BAFF IL17 Inquiry
BSIG-178 Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL23 IL6 Inquiry
BSIG-175 Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 TNF Inquiry
BSIG-172 Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL13 IL17 Inquiry
BSIG-019 Anti-BAFF x Anti-IL17 Bispecific Antibody (IgG-IgG) Human IgG-IgG BAFF IL17 Inquiry
CROSSAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (CrossMab) Human CrossMab IL23 IL6 Inquiry
CROSSAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 TNF Inquiry
CROSSAB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (CrossMab) Human CrossMab IL13 IL17 Inquiry
CROSSAB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (CrossMab) Human CrossMab BAFF IL17 Inquiry
IGFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL23 IL6 Inquiry
IGFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 TNF Inquiry
IGFV-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL13 IL17 Inquiry
IGFV-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (IgG-scFv) Human IgG-scFv BAFF IL17 Inquiry
BSDB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody) Human Diabody IL23 IL6 Inquiry
BSDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 TNF Inquiry
BSDB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Diabody) Human Diabody IL13 IL17 Inquiry
BSDB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Diabody) Human Diabody BAFF IL17 Inquiry
BSFAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL23 IL6 Inquiry
BSFAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 TNF Inquiry
BSFAB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL13 IL17 Inquiry
BSFAB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Tandem Fab) Human Tandem Fab BAFF IL17 Inquiry
BSFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL23 IL6 Inquiry
BSFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 TNF Inquiry
BSFV-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL13 IL17 Inquiry
BSFV-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Tandem scFv) Human Tandem scFv BAFF IL17 Inquiry

Background

IL-23 is a heterodimeric protein containing subunits p19 and p40 originally identified in 2000. IL-17, which has six members ranging from IL-17A to IL-17F, is a pro-inflammatory cytokine first identified in 1993. They are critical in stimulating the immune response in the host's defense against infections and maintaining mucosal surface barrier functions. IL-23/IL-17 pathways have important roles in the pathogenesis of Spondyloarthritis (SpA). As shown in Fig.1, Dendric cells (DCs) and macrophages create IL-23. IL-23 stimulates the synthesis of IL-17 by a variety of cells and contributes to inflammation by increasing the production of inflammatory cytokines such as IL-6 and TNF, which cause inflammation in the enthesis and joint.

Fig.1 IL-23 & IL-17 are important in SpA. (Tsukazaki, Hiroyuki, and Takashi Kaito, 2020) Fig.1 Schematic overview of the role of IL-23 and IL-17 in SpA.1

Reference

  1. Tsukazaki, Hiroyuki, and Takashi Kaito. "The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis." International Journal of Molecular Sciences 21.17 (2020): 6401.
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