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IL17 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BSCC-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17 Mouse TNF Mouse Inquiry
BSCC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17 Mouse IL23 Mouse Inquiry
BSCC-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL13 Mouse IL17 Mouse Inquiry
BSCC-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL BAFF Mouse IL17 Mouse Inquiry
BIBD-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Bibody) Human Bibody IL17 Human TNF Human Inquiry
BIBD-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Bibody) Human Bibody IL17 Human IL23 Human Inquiry
BIBD-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Bibody) Human Bibody IL13 Human IL17 Human Inquiry
BIBD-H199 Recombinant Human Anti-BAFF x Human Anti-IL17 Bispecific Antibody (Bibody) Human Bibody BAFF Human IL17 Human Inquiry
BIBD-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Bibody) Human Bibody IL17 Mouse TNF Mouse Inquiry
BIBD-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Bibody) Human Bibody IL17 Mouse IL23 Mouse Inquiry
BIBD-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Bibody) Human Bibody IL13 Mouse IL17 Mouse Inquiry
BIBD-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Bibody) Human Bibody BAFF Mouse IL17 Mouse Inquiry
FABFV-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Human TNF Human Inquiry
FABFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Human IL23 Human Inquiry
FABFV-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL13 Human IL17 Human Inquiry
FABFV-H199 Recombinant Human Anti-BAFF x Human Anti-IL17 Bispecific Antibody (Fab-Fv) Human Fab-Fv BAFF Human IL17 Human Inquiry
FABFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Mouse TNF Mouse Inquiry
FABFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Mouse IL23 Mouse Inquiry
FABFV-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL13 Mouse IL17 Mouse Inquiry
FABFV-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Fab-Fv) Human Fab-Fv BAFF Mouse IL17 Mouse Inquiry
MiniB-H340 Recombinant Human Anti-IL17 x Human Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 Human TNF Human Inquiry
MiniB-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Minibody) Human Minibody IL17 Human IL23 Human Inquiry
MiniB-H337 Recombinant Human Anti-IL13 x Human Anti-IL17 Bispecific Antibody (Minibody) Human Minibody IL13 Human IL17 Human Inquiry
MiniB-H199 Recombinant Human Anti-BAFF x Human Anti-IL17 Bispecific Antibody (Minibody) Human Minibody BAFF Human IL17 Human Inquiry
MiniB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Minibody) Human Minibody IL17 Mouse TNF Mouse Inquiry
MiniB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Minibody) Human Minibody IL17 Mouse IL23 Mouse Inquiry
MiniB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Minibody) Human Minibody IL13 Mouse IL17 Mouse Inquiry
MiniB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Minibody) Human Minibody BAFF Mouse IL17 Mouse Inquiry
SCDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Human TNF Human Inquiry
SCDB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Human IL23 Human Inquiry
SCDB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL13 Human IL17 Human Inquiry
SCDB-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody BAFF Human IL17 Human Inquiry
FABIG-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Human TNF Human Inquiry
FABIG-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Human IL23 Human Inquiry
FABIG-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL13 Human IL17 Human Inquiry
FABIG-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Fab-IgG) Human Fab-IgG BAFF Human IL17 Human Inquiry
TRIB-H341 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Human TNF Human Inquiry
TRIB-H340 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Human IL23 Human Inquiry
TRIB-H338 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL13 Human IL17 Human Inquiry
TRIB-H199 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv BAFF Human IL17 Human Inquiry
BSIG-H339 Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Human TNF Human Inquiry
BSIG-H338 Human Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Human IL23 Human Inquiry
BSIG-H336 Human Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL13 Human IL17 Human Inquiry
BSIG-H197 Human Anti-BAFF x Anti-IL17 Bispecific Antibody (IgG-IgG) Human IgG-IgG BAFF Human IL17 Human Inquiry
CROSSAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 Human TNF Human Inquiry
CROSSAB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (CrossMab) Human CrossMab IL17 Human IL23 Human Inquiry
CROSSAB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (CrossMab) Human CrossMab IL13 Human IL17 Human Inquiry
CROSSAB-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (CrossMab) Human CrossMab BAFF Human IL17 Human Inquiry
IGFV-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Human TNF Human Inquiry
IGFV-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Human IL23 Human Inquiry
IGFV-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL13 Human IL17 Human Inquiry
IGFV-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (IgG-scFv) Human IgG-scFv BAFF Human IL17 Human Inquiry
BSDB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 Human TNF Human Inquiry
BSDB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody) Human Diabody IL17 Human IL23 Human Inquiry
BSDB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Diabody) Human Diabody IL13 Human IL17 Human Inquiry
BSDB-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Diabody) Human Diabody BAFF Human IL17 Human Inquiry
BSFAB-H339 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Human TNF Human Inquiry
BSFAB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Human IL23 Human Inquiry
BSFAB-H336 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL13 Human IL17 Human Inquiry
BSFAB-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Tandem Fab) Human Tandem Fab BAFF Human IL17 Human Inquiry
BSFV-H337 Recombinant Human Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Human TNF Human Inquiry
BSFV-H336 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Human IL23 Human Inquiry
BSFV-H334 Recombinant Human Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL13 Human IL17 Human Inquiry
BSFV-H197 Recombinant Human Anti-BAFF x Anti-IL17 Bispecific Antibody (Tandem scFv) Human Tandem scFv BAFF Human IL17 Human Inquiry
SCDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Mouse TNF Mouse Inquiry
SCDB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Mouse IL23 Mouse Inquiry
SCDB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL13 Mouse IL17 Mouse Inquiry
SCDB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody BAFF Mouse IL17 Mouse Inquiry
FABIG-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Mouse TNF Mouse Inquiry
FABIG-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Mouse IL23 Mouse Inquiry
FABIG-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL13 Mouse IL17 Mouse Inquiry
FABIG-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Fab-IgG) Human Fab-IgG BAFF Mouse IL17 Mouse Inquiry
TRIB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Mouse TNF Mouse Inquiry
TRIB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Mouse IL23 Mouse Inquiry
TRIB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL13 Mouse IL17 Mouse Inquiry
TRIB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv BAFF Mouse IL17 Mouse Inquiry
BSIG-175 Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Mouse TNF Mouse Inquiry
BSIG-174 Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Mouse IL23 Mouse Inquiry
BSIG-172 Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL13 Mouse IL17 Mouse Inquiry
BSIG-019 Anti-BAFF x Anti-IL17 Bispecific Antibody (IgG-IgG) Human IgG-IgG BAFF Mouse IL17 Mouse Inquiry
CROSSAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (CrossMab) Human CrossMab IL17 Mouse TNF Mouse Inquiry
CROSSAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (CrossMab) Human CrossMab IL17 Mouse IL23 Mouse Inquiry
CROSSAB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (CrossMab) Human CrossMab IL13 Mouse IL17 Mouse Inquiry
CROSSAB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (CrossMab) Human CrossMab BAFF Mouse IL17 Mouse Inquiry
IGFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Mouse TNF Mouse Inquiry
IGFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Mouse IL23 Mouse Inquiry
IGFV-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL13 Mouse IL17 Mouse Inquiry
IGFV-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (IgG-scFv) Human IgG-scFv BAFF Mouse IL17 Mouse Inquiry
BSDB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Diabody) Human Diabody IL17 Mouse TNF Mouse Inquiry
BSDB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody) Human Diabody IL17 Mouse IL23 Mouse Inquiry
BSDB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Diabody) Human Diabody IL13 Mouse IL17 Mouse Inquiry
BSDB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Diabody) Human Diabody BAFF Mouse IL17 Mouse Inquiry
BSFAB-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Mouse TNF Mouse Inquiry
BSFAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Mouse IL23 Mouse Inquiry
BSFAB-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL13 Mouse IL17 Mouse Inquiry
BSFAB-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Tandem Fab) Human Tandem Fab BAFF Mouse IL17 Mouse Inquiry
BSFV-175 Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Mouse TNF Mouse Inquiry
BSFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Mouse IL23 Mouse Inquiry
BSFV-172 Recombinant Anti-IL13 x Anti-IL17 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL13 Mouse IL17 Mouse Inquiry
BSFV-019 Recombinant Anti-BAFF x Anti-IL17 Bispecific Antibody (Tandem scFv) Human Tandem scFv BAFF Mouse IL17 Mouse Inquiry

Background

Interleukin 17A (alias IL17A, IL17, and CTLA8), is a 155 aa homodimeric secreted protein of the Interleukin 17 family (IL17 family) sharing a similar protein structure with other members, containing 4 highly conserved cysteine residues. IL-17A signals predominantly in non-hematopoietic cells to stimulate acute immune responses. IL17(A or F) employs TRAF6 to activate the canonical NF-κB signaling pathway, thus upregulating the expression levels of IκBζ and Bcl3, and further promoting the expression of various anti-microbial or pro-inflammatory genes modulated by IL17-NF-κB. Meanwhile, IL17-NF-κB signaling stimulates negative feedback circuits to repress NF-κB activity within a dynamic balance. Besides, IL17A can function in the pathogenesis of Crohn’s disease (CD) synergistically with IL23, inducing numerous pro-inflammatory molecules like IFNγ, TNF, lymphotoxin IL22, etc. Inhibiting IL17 as a pro-inflammatory mediator can be a promising strategy for biological therapies.

IL17 signaling pathways: transduction and amplification. (McGeachy, et al, 2019) Fig.1 IL17 signaling pathways: transduction and amplification.1

Reference

  1. McGeachy, Mandy J., Daniel J. Cua, and Sarah L. Gaffen. "The IL-17 family of cytokines in health and disease." Immunity 50.4 (2019): 892-906.
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