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IL17A & IL17F Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H340 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL17A Human IL17F Human Inquiry
T-BSDB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL17A Mouse IL17F Mouse Inquiry
SCIGG-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scIgG) Human Single chain IgGs IL17A Human IL17F Human Inquiry
SCIGG-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scIgG) Human Single chain IgGs IL17A Mouse IL17F Mouse Inquiry
BIVHH-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Bi-sdAb) Human Bi-sdAb IL17A llama IL17F llama Inquiry
FVTIG-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL17A Human IL17F Human Inquiry
FVTIG-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL17A Mouse IL17F Mouse Inquiry
BSSG-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv-IgG) Human scFv-IgG IL17A Human IL17F Human Inquiry
BSSG-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv-IgG) Human scFv-IgG IL17A Mouse IL17F Mouse Inquiry
IGLFV-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL17A Human IL17F Human Inquiry
IGLFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL17A Mouse IL17F Mouse Inquiry
BSGV-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (IgG-Fv) Human IgG-Fv IL17A Mouse IL17F Mouse Inquiry
BSGV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG-Fv) Human IgG-Fv IL17A Mouse IL17F Mouse Inquiry
BSDG-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Fv-IgG) Human Fv-IgG IL17A Human IL17F Human Inquiry
BSDG-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fv-IgG) Human Fv-IgG IL17A Mouse IL17F Mouse Inquiry
BABFV-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL17A Human IL17F Human Inquiry
BABFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL17A Mouse IL17F Mouse Inquiry
FABVC-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL17A Human IL17F Human Inquiry
FABVC-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL17A Mouse IL17F Mouse Inquiry
SCDBC-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL17A Human IL17F Human Inquiry
SCDBC-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL17A Mouse IL17F Mouse Inquiry
BSDBC-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL17A Human IL17F Human Inquiry
BSDBC-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL17A Mouse IL17F Mouse Inquiry
SCDBF-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL17A Human IL17F Human Inquiry
SCDBF-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL17A Mouse IL17F Mouse Inquiry
BSFVF-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL17A Human IL17F Human Inquiry
BSFVF-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL17A Mouse IL17F Mouse Inquiry
BSDBF-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL17A Human IL17F Human Inquiry
BSDBF-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL17A Mouse IL17F Mouse Inquiry
BSTF-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL17A Mouse IL17F Mouse Inquiry
BSTF-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL17A Mouse IL17F Mouse Inquiry
BSCFV-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv-Fc) Human scFv-Fc IL17A Mouse IL17F Mouse Inquiry
BSCFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv-Fc) Human scFv-Fc IL17A Mouse IL17F Mouse Inquiry
MNAB-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Miniantibody) Human Miniantibody IL17A Mouse IL17F Mouse Inquiry
MNAB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Miniantibody) Human Miniantibody IL17A Mouse IL17F Mouse Inquiry
BSFC-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL17A Mouse IL17F Mouse Inquiry
BSFC-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL17A Mouse IL17F Mouse Inquiry
BSCC-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17A Mouse IL17F Mouse Inquiry
BSCC-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17A Mouse IL17F Mouse Inquiry
BIBD-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Bibody) Human Bibody IL17A Mouse IL17F Mouse Inquiry
BIBD-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Bibody) Human Bibody IL17A Mouse IL17F Mouse Inquiry
FABFV-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17A Human IL17F Human Inquiry
FABFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17A Mouse IL17F Mouse Inquiry
MiniB-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Minibody) Human Minibody IL17A Human IL17F Human Inquiry
MiniB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Minibody) Human Minibody IL17A Mouse IL17F Mouse Inquiry
SCDB-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17A Human IL17F Human Inquiry
FABIG-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17A Human IL17F Human Inquiry
TRIB-H342 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17A Human IL17F Human Inquiry
BSIG-H340 Human Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17A Human IL17F Human Inquiry
CROSSAB-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (CrossMab) Human CrossMab IL17A Human IL17F Human Inquiry
IGFV-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17A Human IL17F Human Inquiry
BSDB-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Diabody) Human Diabody IL17A Human IL17F Human Inquiry
BSFAB-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17A Human IL17F Human Inquiry
BSFV-H338 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17A Human IL17F Human Inquiry
SCDB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17A Mouse IL17F Mouse Inquiry
FABIG-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17A Mouse IL17F Mouse Inquiry
TRIB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17A Mouse IL17F Mouse Inquiry
BSIG-176 Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17A Mouse IL17F Mouse Inquiry
CROSSAB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (CrossMab) Human CrossMab IL17A Mouse IL17F Mouse Inquiry
IGFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17A Mouse IL17F Mouse Inquiry
BSDB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Diabody) Human Diabody IL17A Mouse IL17F Mouse Inquiry
BSFAB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17A Mouse IL17F Mouse Inquiry
BSFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17A Mouse IL17F Mouse Inquiry

Background

IL-17A and IL-17F belong to the Interleukin 17 (IL-17) family and serve as its principal pro-inflammatory cytokines, marked by a high degree of sequential homogeneity. Both IL-17A and IL-17F are expressed by Th17 cells or other immune cells, binding to the same receptor complex.

Despite substantial functional overlap, IL-17A is commonly believed to possess higher biological activity. IL-17A and IL-17F constitute a bridge between adaptive and innate immunity systems, the activation of which can guide the transduction of the NF-κB pathway, trigger inflammation mediators, and induce chemokine production, thereby soliciting inflammatory cells thus offering protection against pathogens and the maintenance of epithelial barrier functions.

Extensive pathological research suggests the involvement of IL-17A and IL-17F in post-transplantation immune responses. Besides, their overexpression is implicated in the pathogenic mechanism of chronic immune-mediated inflammatory diseases.

Signaling of IL-17 family. (Compan, et al., 2023) Fig.1 IL-17 and receptor family.1

Reference

  1. Compan, Puig, et al. " The paradigm of IL-23 independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases" The Journal of Pathology: Clinical Research. 14 (2023): 1191782.
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