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IL17F Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H340 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL17A Human IL17F Human Inquiry
T-BSDB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL17A Mouse IL17F Mouse Inquiry
SCIGG-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scIgG) Human Single chain IgGs IL17A Human IL17F Human Inquiry
SCIGG-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scIgG) Human Single chain IgGs IL17A Mouse IL17F Mouse Inquiry
BIVHH-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Bi-sdAb) Human Bi-sdAb IL17A llama IL17F llama Inquiry
FVTIG-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL17A Human IL17F Human Inquiry
FVTIG-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL17A Mouse IL17F Mouse Inquiry
BSSG-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv-IgG) Human scFv-IgG IL17A Human IL17F Human Inquiry
BSSG-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv-IgG) Human scFv-IgG IL17A Mouse IL17F Mouse Inquiry
IGLFV-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL17A Human IL17F Human Inquiry
IGLFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL17A Mouse IL17F Mouse Inquiry
BSGV-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (IgG-Fv) Human IgG-Fv IL17A Human IL17F Human Inquiry
BSGV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG-Fv) Human IgG-Fv IL17A Mouse IL17F Mouse Inquiry
BSDG-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Fv-IgG) Human Fv-IgG IL17A Human IL17F Human Inquiry
BSDG-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fv-IgG) Human Fv-IgG IL17A Mouse IL17F Mouse Inquiry
BABFV-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL17A Human IL17F Human Inquiry
BABFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL17A Mouse IL17F Mouse Inquiry
FABVC-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL17A Human IL17F Human Inquiry
FABVC-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL17A Mouse IL17F Mouse Inquiry
SCDBC-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL17A Human IL17F Human Inquiry
SCDBC-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL17A Mouse IL17F Mouse Inquiry
BSDBC-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL17A Human IL17F Human Inquiry
BSDBC-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL17A Mouse IL17F Mouse Inquiry
SCDBF-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL17A Human IL17F Human Inquiry
SCDBF-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL17A Mouse IL17F Mouse Inquiry
BSFVF-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL17A Human IL17F Human Inquiry
BSFVF-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL17A Mouse IL17F Mouse Inquiry
BSDBF-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL17A Human IL17F Human Inquiry
BSDBF-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL17A Mouse IL17F Mouse Inquiry
BSTF-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL17A Human IL17F Human Inquiry
BSTF-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL17A Mouse IL17F Mouse Inquiry
BSCFV-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv-Fc) Human scFv-Fc IL17A Human IL17F Human Inquiry
BSCFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv-Fc) Human scFv-Fc IL17A Mouse IL17F Mouse Inquiry
MNAB-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Miniantibody) Human Miniantibody IL17A Human IL17F Human Inquiry
MNAB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Miniantibody) Human Miniantibody IL17A Mouse IL17F Mouse Inquiry
BSFC-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL17A Human IL17F Human Inquiry
BSFC-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL17A Mouse IL17F Mouse Inquiry
BSCC-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17A Human IL17F Human Inquiry
BSCC-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17A Mouse IL17F Mouse Inquiry
BIBD-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Bibody) Human Bibody IL17A Human IL17F Human Inquiry
BIBD-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Bibody) Human Bibody IL17A Mouse IL17F Mouse Inquiry
FABFV-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17A Human IL17F Human Inquiry
FABFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17A Mouse IL17F Mouse Inquiry
MiniB-H341 Recombinant Human Anti-IL17A x Human Anti-IL17F Bispecific Antibody (Minibody) Human Minibody IL17A Human IL17F Human Inquiry
MiniB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Minibody) Human Minibody IL17A Mouse IL17F Mouse Inquiry
SCDB-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17A Human IL17F Human Inquiry
FABIG-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17A Human IL17F Human Inquiry
TRIB-H342 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17A Human IL17F Human Inquiry
BSIG-H340 Human Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17A Human IL17F Human Inquiry
CROSSAB-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (CrossMab) Human CrossMab IL17A Human IL17F Human Inquiry
IGFV-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17A Human IL17F Human Inquiry
BSDB-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Diabody) Human Diabody IL17A Human IL17F Human Inquiry
BSFAB-H340 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17A Human IL17F Human Inquiry
BSFV-H338 Recombinant Human Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17A Human IL17F Human Inquiry
SCDB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17A Mouse IL17F Mouse Inquiry
FABIG-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17A Mouse IL17F Mouse Inquiry
TRIB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17A Mouse IL17F Mouse Inquiry
BSIG-176 Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17A Mouse IL17F Mouse Inquiry
CROSSAB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (CrossMab) Human CrossMab IL17A Mouse IL17F Mouse Inquiry
IGFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17A Mouse IL17F Mouse Inquiry
BSDB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Diabody) Human Diabody IL17A Mouse IL17F Mouse Inquiry
BSFAB-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17A Mouse IL17F Mouse Inquiry
BSFV-176 Recombinant Anti-IL17A x Anti-IL17F Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17A Mouse IL17F Mouse Inquiry

Background

Fig. 1 Signal transduction of IL17F. (Goepfert, et al., 2020)Fig. 1 Signal transduction of IL17F.1

Interleukin 17F (IL17F) is a member of the IL17 family cytokines derived mainly from differentiated TH17 cells, lamina propria T cells, memory CD4+ T cells, γδ T cells, and natural killer T (NKT) cells. IL17F has the strongest homology with IL17A. Many in vitro studies have confirmed that IL17F has a pro-inflammatory function similar to IL17A, and thus it may contribute to host defense and autoimmunity of TH17 cells. IL17F exists in vivo as a homodimer (IL17F-F) or heterodimer (IL17F-A). By signaling through dimeric receptors composed of IL17RA or IL17RC, IL17F promotes the expression of other pro-inflammatory cytokines (e.g., IL-6, IL-1β, and IL-20 family cytokines) and effector proteins, leading to further activation of neutrophils, macrophages, epithelial cells, and fibroblasts. IL17F plays an important role in many autoimmune disorders, including psoriasis, ankylosing spondylitis, and ulcerative colitis.

Reference

  1. Goepfert, A.; et al. Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. Immunity. 2020, 52(3): 499-512.e5.
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