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IL23 & IL6 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H342 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL23 Human IL6 Human Inquiry
T-BSDB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL23 Mouse IL6 Mouse Inquiry
SCIGG-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scIgG) Human Single chain IgGs IL23 Human IL6 Human Inquiry
SCIGG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scIgG) Human Single chain IgGs IL23 Mouse IL6 Mouse Inquiry
FVTIG-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL23 Human IL6 Human Inquiry
FVTIG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL23 Mouse IL6 Mouse Inquiry
BSSG-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-IgG) Human scFv-IgG IL23 Human IL6 Human Inquiry
BSSG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-IgG) Human scFv-IgG IL23 Mouse IL6 Mouse Inquiry
IGLFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL23 Human IL6 Human Inquiry
IGLFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL23 Mouse IL6 Mouse Inquiry
BSGV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL23 Mouse IL6 Mouse Inquiry
BSGV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL23 Mouse IL6 Mouse Inquiry
BSDG-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL23 Human IL6 Human Inquiry
BSDG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL23 Mouse IL6 Mouse Inquiry
BABFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL23 Human IL6 Human Inquiry
BABFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL23 Mouse IL6 Mouse Inquiry
FABVC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL23 Human IL6 Human Inquiry
FABVC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL23 Mouse IL6 Mouse Inquiry
SCDBC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL23 Human IL6 Human Inquiry
SCDBC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL23 Mouse IL6 Mouse Inquiry
BSDBC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL23 Human IL6 Human Inquiry
BSDBC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL23 Mouse IL6 Mouse Inquiry
SCDBF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL23 Human IL6 Human Inquiry
SCDBF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL23 Mouse IL6 Mouse Inquiry
BSFVF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL23 Human IL6 Human Inquiry
BSFVF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL23 Mouse IL6 Mouse Inquiry
BSDBF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL23 Human IL6 Human Inquiry
BSDBF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL23 Mouse IL6 Mouse Inquiry
BSTF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL23 Mouse IL6 Mouse Inquiry
BSTF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL23 Mouse IL6 Mouse Inquiry
BSCFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL23 Mouse IL6 Mouse Inquiry
BSCFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL23 Mouse IL6 Mouse Inquiry
MNAB-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Miniantibody) Human Miniantibody IL23 Mouse IL6 Mouse Inquiry
MNAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Miniantibody) Human Miniantibody IL23 Mouse IL6 Mouse Inquiry
BSFC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL23 Mouse IL6 Mouse Inquiry
BSFC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL23 Mouse IL6 Mouse Inquiry
BSCC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL23 Mouse IL6 Mouse Inquiry
BSCC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL23 Mouse IL6 Mouse Inquiry
BIBD-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Bibody) Human Bibody IL23 Mouse IL6 Mouse Inquiry
BIBD-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Bibody) Human Bibody IL23 Mouse IL6 Mouse Inquiry
FABFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL23 Human IL6 Human Inquiry
FABFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL23 Mouse IL6 Mouse Inquiry
MiniB-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Minibody) Human Minibody IL23 Human IL6 Human Inquiry
MiniB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Minibody) Human Minibody IL23 Mouse IL6 Mouse Inquiry
SCDB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL23 Human IL6 Human Inquiry
FABIG-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL23 Human IL6 Human Inquiry
TRIB-H344 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL23 Human IL6 Human Inquiry
BSIG-H342 Human Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL23 Human IL6 Human Inquiry
CROSSAB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (CrossMab) Human CrossMab IL23 Human IL6 Human Inquiry
IGFV-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL23 Human IL6 Human Inquiry
BSDB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody) Human Diabody IL23 Human IL6 Human Inquiry
BSFAB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL23 Human IL6 Human Inquiry
BSFV-H340 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL23 Human IL6 Human Inquiry
SCDB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL23 Mouse IL6 Mouse Inquiry
FABIG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL23 Mouse IL6 Mouse Inquiry
TRIB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL23 Mouse IL6 Mouse Inquiry
BSIG-178 Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL23 Mouse IL6 Mouse Inquiry
CROSSAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (CrossMab) Human CrossMab IL23 Mouse IL6 Mouse Inquiry
IGFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL23 Mouse IL6 Mouse Inquiry
BSDB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody) Human Diabody IL23 Mouse IL6 Mouse Inquiry
BSFAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL23 Mouse IL6 Mouse Inquiry
BSFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL23 Mouse IL6 Mouse Inquiry
BSDG-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL17 Human IL23 Human Inquiry
BSDG-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL17 Mouse IL23 Mouse Inquiry
BABFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL17 Human IL23 Human Inquiry
BABFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL17 Mouse IL23 Mouse Inquiry
FABVC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL17 Human IL23 Human Inquiry
FABVC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL17 Mouse IL23 Mouse Inquiry
SCDBC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL17 Human IL23 Human Inquiry
SCDBC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL17 Mouse IL23 Mouse Inquiry
BSDBC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL17 Human IL23 Human Inquiry
BSDBC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL17 Mouse IL23 Mouse Inquiry
SCDBF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL17 Human IL23 Human Inquiry
SCDBF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL17 Mouse IL23 Mouse Inquiry
BSFVF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL17 Human IL23 Human Inquiry
BSFVF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL17 Mouse IL23 Mouse Inquiry
BSDBF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL17 Human IL23 Human Inquiry
BSDBF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL17 Mouse IL23 Mouse Inquiry
BSTF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL17 Mouse IL23 Mouse Inquiry
BSTF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL17 Mouse IL23 Mouse Inquiry
BSCFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL17 Mouse IL23 Mouse Inquiry
BSCFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL17 Mouse IL23 Mouse Inquiry
MNAB-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Miniantibody) Human Miniantibody IL17 Mouse IL23 Mouse Inquiry
MNAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Miniantibody) Human Miniantibody IL17 Mouse IL23 Mouse Inquiry
BSFC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL17 Mouse IL23 Mouse Inquiry
BSFC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL17 Mouse IL23 Mouse Inquiry
BSCC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17 Mouse IL23 Mouse Inquiry
BSCC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17 Mouse IL23 Mouse Inquiry
BIBD-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Bibody) Human Bibody IL17 Mouse IL23 Mouse Inquiry
BIBD-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Bibody) Human Bibody IL17 Mouse IL23 Mouse Inquiry
FABFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Human IL23 Human Inquiry
FABFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Mouse IL23 Mouse Inquiry
MiniB-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Minibody) Human Minibody IL17 Human IL23 Human Inquiry
MiniB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Minibody) Human Minibody IL17 Mouse IL23 Mouse Inquiry
SCDB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Human IL23 Human Inquiry
FABIG-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Human IL23 Human Inquiry
TRIB-H340 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Human IL23 Human Inquiry
BSIG-H338 Human Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Human IL23 Human Inquiry
CROSSAB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (CrossMab) Human CrossMab IL17 Human IL23 Human Inquiry
IGFV-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Human IL23 Human Inquiry
BSDB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody) Human Diabody IL17 Human IL23 Human Inquiry
BSFAB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Human IL23 Human Inquiry
BSFV-H336 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Human IL23 Human Inquiry
SCDB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Mouse IL23 Mouse Inquiry
FABIG-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Mouse IL23 Mouse Inquiry
TRIB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Mouse IL23 Mouse Inquiry
BSIG-174 Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Mouse IL23 Mouse Inquiry
CROSSAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (CrossMab) Human CrossMab IL17 Mouse IL23 Mouse Inquiry
IGFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Mouse IL23 Mouse Inquiry
BSDB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody) Human Diabody IL17 Mouse IL23 Mouse Inquiry
BSFAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Mouse IL23 Mouse Inquiry
BSFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Mouse IL23 Mouse Inquiry

Background

IL-23, an inflammatory cytokine principally expressed by dendritic cells, macrophages, or monocytes, binds with numerous other cells via their IL-23R surface receptors, thus initiating downstream signals. Primarily, the signaling of IL-23 activates IL-17 and other effector cytokines, thereby propelling a protective immune response against fungal and bacterial infections in the host.

Regarded as a primary regulator of health and disease intervention, IL-6 is an immune modulatory cytokine. IL-6 signaling transduction pathways invariably engage the JAK/STAT3 downstream pathway, thereby stimulating the production of anti-inflammatory cytokines, marshaling immune cells, and impeding the DNA damage of malignant tumor cells.

While IL-23 is implicated in various chronic immune-mediated inflammations, aberrations in the function or expression of IL-6 are thought to catalyze the onset of tumors. Moreover, pathways of IL-23/STAT3 and IL-6/STAT3 play a significant role in influencing the differentiation of Th17 cells and are considered to be risk alleles for multiple sclerosis. Bispecific antibodies targeting both IL23 and IL6 targets are considered a potential inflammatory intervention strategy.

Diseases involved with both IL-23 and IL-6. (Schinocca, et al., 2021) Fig.1 IL-23 and IL-6-correlated diseases.1

Reference

  1. Schinocca, Rizzo, et al. " Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview" Frontiers in Immunology. 12 (2021): 637829.
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