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IL23 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BSDG-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL23 Human IL6 Human Inquiry
BSDG-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL17 Human IL23 Human Inquiry
BSDG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL23 Mouse IL6 Mouse Inquiry
BSDG-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL17 Mouse IL23 Mouse Inquiry
BABFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL23 Human IL6 Human Inquiry
BABFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL17 Human IL23 Human Inquiry
BABFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL23 Mouse IL6 Mouse Inquiry
BABFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL17 Mouse IL23 Mouse Inquiry
FABVC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL23 Human IL6 Human Inquiry
FABVC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL17 Human IL23 Human Inquiry
FABVC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL23 Mouse IL6 Mouse Inquiry
FABVC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL17 Mouse IL23 Mouse Inquiry
SCDBC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL23 Human IL6 Human Inquiry
SCDBC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL17 Human IL23 Human Inquiry
SCDBC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL23 Mouse IL6 Mouse Inquiry
SCDBC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL17 Mouse IL23 Mouse Inquiry
BSDBC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL23 Human IL6 Human Inquiry
BSDBC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL17 Human IL23 Human Inquiry
BSDBC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL23 Mouse IL6 Mouse Inquiry
BSDBC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL17 Mouse IL23 Mouse Inquiry
SCDBF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL23 Human IL6 Human Inquiry
SCDBF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL17 Human IL23 Human Inquiry
SCDBF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL23 Mouse IL6 Mouse Inquiry
SCDBF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL17 Mouse IL23 Mouse Inquiry
BSFVF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL23 Human IL6 Human Inquiry
BSFVF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL17 Human IL23 Human Inquiry
BSFVF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL23 Mouse IL6 Mouse Inquiry
BSFVF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL17 Mouse IL23 Mouse Inquiry
BSDBF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL23 Human IL6 Human Inquiry
BSDBF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL17 Human IL23 Human Inquiry
BSDBF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL23 Mouse IL6 Mouse Inquiry
BSDBF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL17 Mouse IL23 Mouse Inquiry
BSTF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL23 Mouse IL6 Mouse Inquiry
BSTF-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL17 Mouse IL23 Mouse Inquiry
BSTF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL23 Mouse IL6 Mouse Inquiry
BSTF-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL17 Mouse IL23 Mouse Inquiry
BSCFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL23 Mouse IL6 Mouse Inquiry
BSCFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL17 Mouse IL23 Mouse Inquiry
BSCFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL23 Mouse IL6 Mouse Inquiry
BSCFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL17 Mouse IL23 Mouse Inquiry
MNAB-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Miniantibody) Human Miniantibody IL23 Mouse IL6 Mouse Inquiry
MNAB-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Miniantibody) Human Miniantibody IL17 Mouse IL23 Mouse Inquiry
MNAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Miniantibody) Human Miniantibody IL23 Mouse IL6 Mouse Inquiry
MNAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Miniantibody) Human Miniantibody IL17 Mouse IL23 Mouse Inquiry
BSFC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL23 Mouse IL6 Mouse Inquiry
BSFC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL17 Mouse IL23 Mouse Inquiry
BSFC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL23 Mouse IL6 Mouse Inquiry
BSFC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL17 Mouse IL23 Mouse Inquiry
BSCC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL23 Mouse IL6 Mouse Inquiry
BSCC-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17 Mouse IL23 Mouse Inquiry
BSCC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL23 Mouse IL6 Mouse Inquiry
BSCC-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL17 Mouse IL23 Mouse Inquiry
BIBD-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Bibody) Human Bibody IL23 Mouse IL6 Mouse Inquiry
BIBD-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Bibody) Human Bibody IL17 Mouse IL23 Mouse Inquiry
BIBD-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Bibody) Human Bibody IL23 Mouse IL6 Mouse Inquiry
BIBD-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Bibody) Human Bibody IL17 Mouse IL23 Mouse Inquiry
FABFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL23 Human IL6 Human Inquiry
FABFV-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Human IL23 Human Inquiry
FABFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL23 Mouse IL6 Mouse Inquiry
FABFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL17 Mouse IL23 Mouse Inquiry
MiniB-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Minibody) Human Minibody IL23 Human IL6 Human Inquiry
MiniB-H339 Recombinant Human Anti-IL17 x Human Anti-IL23 Bispecific Antibody (Minibody) Human Minibody IL17 Human IL23 Human Inquiry
MiniB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Minibody) Human Minibody IL23 Mouse IL6 Mouse Inquiry
MiniB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Minibody) Human Minibody IL17 Mouse IL23 Mouse Inquiry
SCDB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL23 Human IL6 Human Inquiry
SCDB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Human IL23 Human Inquiry
FABIG-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL23 Human IL6 Human Inquiry
FABIG-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Human IL23 Human Inquiry
TRIB-H344 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL23 Human IL6 Human Inquiry
TRIB-H340 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Human IL23 Human Inquiry
BSIG-H342 Human Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL23 Human IL6 Human Inquiry
BSIG-H338 Human Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Human IL23 Human Inquiry
CROSSAB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (CrossMab) Human CrossMab IL23 Human IL6 Human Inquiry
CROSSAB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (CrossMab) Human CrossMab IL17 Human IL23 Human Inquiry
IGFV-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL23 Human IL6 Human Inquiry
IGFV-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Human IL23 Human Inquiry
BSDB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody) Human Diabody IL23 Human IL6 Human Inquiry
BSDB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody) Human Diabody IL17 Human IL23 Human Inquiry
BSFAB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL23 Human IL6 Human Inquiry
BSFAB-H338 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Human IL23 Human Inquiry
BSFV-H340 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL23 Human IL6 Human Inquiry
BSFV-H336 Recombinant Human Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Human IL23 Human Inquiry
SCDB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL23 Mouse IL6 Mouse Inquiry
SCDB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL17 Mouse IL23 Mouse Inquiry
FABIG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL23 Mouse IL6 Mouse Inquiry
FABIG-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL17 Mouse IL23 Mouse Inquiry
TRIB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL23 Mouse IL6 Mouse Inquiry
TRIB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL17 Mouse IL23 Mouse Inquiry
BSIG-178 Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL23 Mouse IL6 Mouse Inquiry
BSIG-174 Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL17 Mouse IL23 Mouse Inquiry
CROSSAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (CrossMab) Human CrossMab IL23 Mouse IL6 Mouse Inquiry
CROSSAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (CrossMab) Human CrossMab IL17 Mouse IL23 Mouse Inquiry
IGFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL23 Mouse IL6 Mouse Inquiry
IGFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL17 Mouse IL23 Mouse Inquiry
BSDB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody) Human Diabody IL23 Mouse IL6 Mouse Inquiry
BSDB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Diabody) Human Diabody IL17 Mouse IL23 Mouse Inquiry
BSFAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL23 Mouse IL6 Mouse Inquiry
BSFAB-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL17 Mouse IL23 Mouse Inquiry
BSFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL23 Mouse IL6 Mouse Inquiry
BSFV-174 Recombinant Anti-IL17 x Anti-IL23 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL17 Mouse IL23 Mouse Inquiry

Background

Interleukin 23 (IL23) is a heterodimeric cytokine consisting of two subunits, IL12β p40 and IL23α p19. IL23 belongs to the IL12 family of cytokines that are mainly generated by macrophages, activated dendritic cells, and monocytes. The main biological effects of IL23 include stimulating the antigen presentation of dendritic cells, the differentiation of T cells to Th17 cells, and the production of interferon-y (IFN-y). IL23 also acts directly on macrophages to perform its function as a terminal effector cytokine. As a key pro-inflammatory cytokine, IL23 has been shown to play a critical role in chronic inflammatory diseases, including Crohn's disease, ulcerative colitis, and psoriasis, making it one of the most promising therapeutic targets for chronic inflammatory joint disease.

Fig. 1 Role of IL23 in chronic inflammatory diseases. (Pastor-Fernández, et al., 2020)Fig. 1 Role of IL23 in chronic inflammatory diseases.1

Reference

  1. Pastor-Fernández, G.; et al. Decoding IL-23 Signaling Cascade for New Therapeutic Opportunities. Cells. 2020, 9(9): 2044.
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