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IL2R Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H267 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human IL2R Human Inquiry
T-BSDB-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse IL2R Mouse Inquiry
SCIGG-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human IL2R Human Inquiry
SCIGG-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse IL2R Mouse Inquiry
FVTIG-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human IL2R Human Inquiry
FVTIG-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse IL2R Mouse Inquiry
BSSG-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human IL2R Human Inquiry
BSSG-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse IL2R Mouse Inquiry
IGLFV-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human IL2R Human Inquiry
IGLFV-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse IL2R Mouse Inquiry
BSGV-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Human IL2R Human Inquiry
BSGV-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse IL2R Mouse Inquiry
BSDG-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human IL2R Human Inquiry
BSDG-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse IL2R Mouse Inquiry
BABFV-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human IL2R Human Inquiry
BABFV-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse IL2R Mouse Inquiry
FABVC-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human IL2R Human Inquiry
FABVC-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse IL2R Mouse Inquiry
SCDBC-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human IL2R Human Inquiry
SCDBC-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse IL2R Mouse Inquiry
BSDBC-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human IL2R Human Inquiry
BSDBC-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse IL2R Mouse Inquiry
SCDBF-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human IL2R Human Inquiry
SCDBF-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse IL2R Mouse Inquiry
BSFVF-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human IL2R Human Inquiry
BSFVF-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse IL2R Mouse Inquiry
BSDBF-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human IL2R Human Inquiry
BSDBF-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse IL2R Mouse Inquiry
BSTF-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Human IL2R Human Inquiry
BSTF-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse IL2R Mouse Inquiry
BSCFV-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Human IL2R Human Inquiry
BSCFV-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse IL2R Mouse Inquiry
MNAB-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Human IL2R Human Inquiry
MNAB-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse IL2R Mouse Inquiry
BSFC-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Human IL2R Human Inquiry
BSFC-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse IL2R Mouse Inquiry
BSCC-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Human IL2R Human Inquiry
BSCC-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse IL2R Mouse Inquiry
BIBD-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (Bibody) Human Bibody CD3 Human IL2R Human Inquiry
BIBD-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Bibody) Human Bibody CD3 Mouse IL2R Mouse Inquiry
FABFV-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human IL2R Human Inquiry
FABFV-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse IL2R Mouse Inquiry
MiniB-H269 Recombinant Human Anti-CD3 x Human Anti-IL2R Bispecific Antibody (Minibody) Human Minibody CD3 Human IL2R Human Inquiry
MiniB-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Minibody) Human Minibody CD3 Mouse IL2R Mouse Inquiry
SCTB-H163 Recombinant Human Anti-IL2R x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human IL2R Human Inquiry
SCDB-H267 Recombinant Human Anti-CD3 x Anti-IL2R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human IL2R Human Inquiry
FABIG-H267 Recombinant Human Anti-CD3 x Anti-IL2R Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human IL2R Human Inquiry
TRIB-H269 Recombinant Human Anti-CD3 x Anti-IL2R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human IL2R Human Inquiry
BSIG-H267 Human Anti-CD3 x Anti-IL2R Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human IL2R Human Inquiry
CROSSAB-H267 Recombinant Human Anti-CD3 x Anti-IL2R Bispecific Antibody (CrossMab) Human CrossMab CD3 Human IL2R Human Inquiry
IGFV-H267 Recombinant Human Anti-CD3 x Anti-IL2R Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human IL2R Human Inquiry
BSDB-H267 Recombinant Human Anti-CD3 x Anti-IL2R Bispecific Antibody (Diabody) Human Diabody CD3 Human IL2R Human Inquiry
BSFAB-H267 Recombinant Human Anti-CD3 x Anti-IL2R Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human IL2R Human Inquiry
BSFV-H267 Recombinant Human Anti-CD3 x Anti-IL2R Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human IL2R Human Inquiry
SCTB-066 Recombinant Anti-IL2R x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse IL2R Mouse Inquiry
SCDB-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse IL2R Mouse Inquiry
FABIG-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse IL2R Mouse Inquiry
TRIB-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse IL2R Mouse Inquiry
BSIG-093 Anti-CD3 x Anti-IL2R Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse IL2R Mouse Inquiry
CROSSAB-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse IL2R Mouse Inquiry
IGFV-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse IL2R Mouse Inquiry
BSDB-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Diabody) Human Diabody CD3 Mouse IL2R Mouse Inquiry
BSFAB-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse IL2R Mouse Inquiry
BSFV-093 Recombinant Anti-CD3 x Anti-IL2R Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse IL2R Mouse Inquiry

Background

The IL2R, a high-affinity tri-molecular receptor, comprises three subunits, namely interleukin-2 receptor alpha and beta chains, and the common gamma chain. Treg expresses IL2R, also induced upon T-cell activation. Elevated levels of soluble IL-2R serve as indicators of immune response, shedding light on immune-mediated diseases during immune activation. The IL2-IL2R pathway is initiated by a cascade of signal transduction events upstream, orchestrated by the collaborative action of AP-1, NF-κB, and NF-AT. Transcription factor activation culminates in the induction of a myriad of genes, encompassing the IL2 gene. Concurrently, activation of the mTOR and MAPK pathways unfolds as integral components of this intricate cellular response.

Deciphering the intricacies of IL2-IL2R pathway signal transduction. (Damoiseaux, et al., 2020) Fig.1 Deciphering the intricacies of IL2-IL2R pathway signal transduction.1

Reference

  1. Damoiseaux, Jan. "The IL-2-IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor." Clinical Immunology 218 (2020): 108515.
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