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IL6 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H342 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL23 Human IL6 Human Inquiry
T-BSDB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody IL23 Mouse IL6 Mouse Inquiry
SCIGG-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scIgG) Human Single chain IgGs IL23 Human IL6 Human Inquiry
SCIGG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scIgG) Human Single chain IgGs IL23 Mouse IL6 Mouse Inquiry
FVTIG-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL23 Human IL6 Human Inquiry
FVTIG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig IL23 Mouse IL6 Mouse Inquiry
BSSG-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-IgG) Human scFv-IgG IL23 Human IL6 Human Inquiry
BSSG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-IgG) Human scFv-IgG IL23 Mouse IL6 Mouse Inquiry
IGLFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL23 Human IL6 Human Inquiry
IGLFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv IL23 Mouse IL6 Mouse Inquiry
BSGV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL23 Mouse IL6 Mouse Inquiry
BSGV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-Fv) Human IgG-Fv IL23 Mouse IL6 Mouse Inquiry
BSDG-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL23 Human IL6 Human Inquiry
BSDG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fv-IgG) Human Fv-IgG IL23 Mouse IL6 Mouse Inquiry
BABFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL23 Human IL6 Human Inquiry
BABFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 IL23 Mouse IL6 Mouse Inquiry
FABVC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL23 Human IL6 Human Inquiry
FABVC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc IL23 Mouse IL6 Mouse Inquiry
SCDBC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL23 Human IL6 Human Inquiry
SCDBC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 IL23 Mouse IL6 Mouse Inquiry
BSDBC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL23 Human IL6 Human Inquiry
BSDBC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 IL23 Mouse IL6 Mouse Inquiry
SCDBF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL23 Human IL6 Human Inquiry
SCDBF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc IL23 Mouse IL6 Mouse Inquiry
BSFVF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL23 Human IL6 Human Inquiry
BSFVF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc IL23 Mouse IL6 Mouse Inquiry
BSDBF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL23 Human IL6 Human Inquiry
BSDBF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc IL23 Mouse IL6 Mouse Inquiry
BSTF-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL23 Mouse IL6 Mouse Inquiry
BSTF-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv IL23 Mouse IL6 Mouse Inquiry
BSCFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL23 Mouse IL6 Mouse Inquiry
BSCFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-Fc) Human scFv-Fc IL23 Mouse IL6 Mouse Inquiry
MNAB-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Miniantibody) Human Miniantibody IL23 Mouse IL6 Mouse Inquiry
MNAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Miniantibody) Human Miniantibody IL23 Mouse IL6 Mouse Inquiry
BSFC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL23 Mouse IL6 Mouse Inquiry
BSFC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-CH3) Human scFv-CH3 IL23 Mouse IL6 Mouse Inquiry
BSCC-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL23 Mouse IL6 Mouse Inquiry
BSCC-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL IL23 Mouse IL6 Mouse Inquiry
BIBD-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Bibody) Human Bibody IL23 Mouse IL6 Mouse Inquiry
BIBD-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Bibody) Human Bibody IL23 Mouse IL6 Mouse Inquiry
FABFV-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL23 Human IL6 Human Inquiry
FABFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-Fv) Human Fab-Fv IL23 Mouse IL6 Mouse Inquiry
MiniB-H343 Recombinant Human Anti-IL23 x Human Anti-IL6 Bispecific Antibody (Minibody) Human Minibody IL23 Human IL6 Human Inquiry
MiniB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Minibody) Human Minibody IL23 Mouse IL6 Mouse Inquiry
SCDB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL23 Human IL6 Human Inquiry
FABIG-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL23 Human IL6 Human Inquiry
TRIB-H344 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL23 Human IL6 Human Inquiry
BSIG-H342 Human Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL23 Human IL6 Human Inquiry
CROSSAB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (CrossMab) Human CrossMab IL23 Human IL6 Human Inquiry
IGFV-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL23 Human IL6 Human Inquiry
BSDB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody) Human Diabody IL23 Human IL6 Human Inquiry
BSFAB-H342 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL23 Human IL6 Human Inquiry
BSFV-H340 Recombinant Human Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL23 Human IL6 Human Inquiry
SCDB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody IL23 Mouse IL6 Mouse Inquiry
FABIG-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-IgG) Human Fab-IgG IL23 Mouse IL6 Mouse Inquiry
TRIB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv IL23 Mouse IL6 Mouse Inquiry
BSIG-178 Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-IgG) Human IgG-IgG IL23 Mouse IL6 Mouse Inquiry
CROSSAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (CrossMab) Human CrossMab IL23 Mouse IL6 Mouse Inquiry
IGFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (IgG-scFv) Human IgG-scFv IL23 Mouse IL6 Mouse Inquiry
BSDB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Diabody) Human Diabody IL23 Mouse IL6 Mouse Inquiry
BSFAB-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem Fab) Human Tandem Fab IL23 Mouse IL6 Mouse Inquiry
BSFV-178 Recombinant Anti-IL23 x Anti-IL6 Bispecific Antibody (Tandem scFv) Human Tandem scFv IL23 Mouse IL6 Mouse Inquiry

Background

Interleukin-6 (IL-6), composed of 184 amino acids, is originally identified as B-cell stimulatory factor 2 (BSF-2) that promotes immunoglobulin synthesis by activated B cells. Its complementary DNA was successfully cloned in 1986. Many factors can induce the expression of IL-6, including tumor necrosis factor (TNF), interleukin-1 (IL-1), platelet-derived growth factor (PDGF), and other cytokines. In bacterial and viral infections, microbial components such as lipopolysaccharide (LPS) are also potent inducers of IL-6. IL-6 plays an important role in host defense and is a pleiotropic cytokine that has a variety of biological activities, including stimulating B cell differentiation, activating thymus cells and T cells, triggering the macrophage, stimulating the liver cells to produce acute phase protein, activating natural killer (natural killer, NK) cells, etc. It also has anti-inflammatory properties. Currently, the most widely studied inhibitory effect of the IL-6 method is the use of monoclonal antibodies, anti-IL6 therapy has been developed for the treatment of immune disorders and cancers.

Fig.1 Basis for pharmacologic effects of IL6 antagonists. (Rossi, 2015) Fig.1 Basis for pharmacologic effects of IL6 antagonists.1

Reference

  1. Rossi, Jean-François, et al. "Interleukin-6 as a therapeutic target." Clinical Cancer Research 21.6 (2015): 1248-1257.
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