The molecule designated as KIT (CD117) is identified as a transmembrane tyrosine kinase growth factor, primarily ligated by the stem cell factor (SCF). KIT and associated downstream pathways can be activated by both soluble and membrane-bound SCF. The activity of KIT is paramount in the life cycle, proliferation, and differentiation of bone marrow hematopoietic stem cells, particularly mast cells. There exists evidence indicative of the involvement of KIT signaling in immune responses.
Fig.1 KIT signaling pathway.1
Vascular cell adhesion molecule-1 (VCAM-1) is a critical endothelial adhesion receptor, whose ligands encompass VLA-4, a9b1, a4b7, aMb2, and other integrins. VCAM-1 is involved in the cellular immunological processes of leukocyte recruitment, adhesion, and trans-endothelial cell migration. Researchers have confirmed VCAM-1 plays a pivotal role in the pathogenesis of cardiovascular diseases, infectious conditions, autoimmune diseases, and tumors.
The dual-specific antibodies targeting both Kit and VCAM-1 may represent a potential generation of disease intervention strategies.
Reference
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