Kit (KIT proto-oncogene receptor tyrosine kinase), also referred to CD117 or C-kit, is a receptor tyrosine kinase encoding the human homolog named c-kit, a proto-oncogene. It is also a type III transmembrane cell surface receptor for MGF (Mast cell growth factor). Kit is expressed as a 145 kDa glycosylated protein with an extracellular domain of 5 Ig-like domains, a transmembrane region, and a tyrosine kinase domain. Mutations in this gene have connections with mast cell disease, gastrointestinal stromal tumors, piebaldism and acute myelogenous leukemia. Its activation is involved in the oncogenic activity of gastrointestinal stromal tumors, lung cancer, melanomas, and others. KIT with its ligand, KITLG, play an important role in regulating cell development, survival and proliferation and function in gametogenesis hematopoiesis, and melanogenesis. Vascular cell adhesion molecule-1 (VCAM-1), also known as vascular cell adhesion protein 1 or CD106, is a transmembrane glycoprotein with the weight of 110 kDa. VCAM-1 is a cytokine-inducible surface molecule expressed only on cytokine-activated endothelium. As an immunoglobulin-like adhesion molecule, VCAM-1 plays an important part in mediating the adhesion of various leukocyte types, including lymphocytes, monocytes, and eosinophils. VCAM-1 is a ligand for α4β1 (VLA-4) and α4β7 integrins. Importantly, VCAM-1 can mediate not only rolling-type adhesion but also firm adhesion via its avidity.