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LPA Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (Tandem Diabody) Human Tandem Diabody AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
SCIGG-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (scIgG) Human Single chain IgGs AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
FVTIG-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (scFv4-Ig) Human scFv4-Ig AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BSSG-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (scFv-IgG) Human scFv-IgG AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
IGLFV-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BSGV-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (IgG-Fv) Human IgG-Fv AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BSDG-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (Fv-IgG) Human Fv-IgG AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BABFV-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
FABVC-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
SCDBC-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BSDBC-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
SCDBF-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BSFVF-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BSDBF-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (Diabody-Fc) Human Diabody-Fc AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BSTF-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BSCFV-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (scFv-Fc) Human scFv-Fc AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
MNAB-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (Miniantibody) Human Miniantibody AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BSFC-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (scFv-CH3) Human scFv-CH3 AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BSCC-011 Recombinant Anti-AP (alkaline phosphatase) x Anti-LPA Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL AP (alkaline phosphatase) Mouse LPA Mouse Inquiry
BIBD-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (Bibody) Human Bibody AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
FABFV-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (Fab-Fv) Human Fab-Fv AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
MiniB-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (Minibody) Human Minibody AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
SCDB-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
FABIG-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (Fab-IgG) Human Fab-IgG AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
TRIB-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
BSIG-011 Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (IgG-IgG) Human IgG-IgG AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
CROSSAB-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (CrossMab) Human CrossMab AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
IGFV-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (IgG-scFv) Human IgG-scFv AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
BSDB-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (Diabody) Human Diabody AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
BSFAB-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (Tandem Fab) Human Tandem Fab AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry
BSFV-011 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-LPA Bispecific Antibody (Tandem scFv) Human Tandem scFv AP (Alkaline Phosphatase) Mouse LPA Mouse Inquiry

Background

Lipoprotein(a) (LPA) is a lipoprotein composed of a lipid-rich domain and an apo(a) binds to apolipoprotein B100 (apoB) by a single disulfide bond. LPA has been widely recognized as a key modulator for atherosclerosis, thrombosis, and aortic valve calcification. Apo(a) KIV structures type 10 can be found in the lipid phase, which provide binding sites for proatherogenic and proinflammatory oxidized phospholipids. There have been genetic and epidemiological studies jointly indicating a dose-dependent and direct correlation between levels of LPA and risks of atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valvular disease (CAVD). Based on these mechanisms, LPA has been considered as an alternative target to be added to therapeutic armamentarium against ASCVD and CAVD. Currently, there are several therapeutics directly targeting LPA undergoing preclinical or clinical trials.

Structure, properties, regulation, and relation to disease of LPA. (Reyes-Soffer, et al, 2022) Fig.1 Structure, properties, regulation, and relation to disease of LPA.1

Reference

  1. Reyes-Soffer, Gissette, et al. "Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart Association." Arteriosclerosis, thrombosis, and vascular biology 42.1 (2022): e48-e60.
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