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MRP1 & CD28 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0825-JL7 Anti-MRP1 x Anti-CD28 Bispecific aptamer (RNA/RNA) Human Bispecific Aptamer MRP1 CD28 Inquiry
SCDB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Mouse CD30 Mouse Inquiry
SCDB-054 Recombinant Anti-CD28 x Anti-CD3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Mouse CD3 Mouse Inquiry
SCDB-050 Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD20 Mouse CD28 Mouse Inquiry
SCDB-040 Recombinant Anti-CD19 x Anti-CD28 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Mouse CD28 Mouse Inquiry
FABIG-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse CSPG4 Mouse Inquiry
FABIG-062 Recombinant Anti-CD28 x Anti-MUC1 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse MUC1 Mouse Inquiry
FABIG-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse HN Mouse Inquiry
FABIG-060 Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse FOLR1 Mouse Inquiry
FABIG-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse EPCAM Mouse Inquiry
FABIG-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse EGFR Mouse Inquiry
FABIG-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse CD44 Mouse Inquiry
FABIG-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse CD40 Mouse Inquiry
FABIG-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse CD30 Mouse Inquiry
FABIG-054 Recombinant Anti-CD28 x Anti-CD3 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse CD3 Mouse Inquiry
FABIG-050 Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD20 Mouse CD28 Mouse Inquiry
FABIG-040 Recombinant Anti-CD19 x Anti-CD28 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Mouse CD28 Mouse Inquiry
TRIB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse CSPG4 Mouse Inquiry
TRIB-062 Recombinant Anti-CD28 x Anti-MUC1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse MUC1 Mouse Inquiry
TRIB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse HN Mouse Inquiry
TRIB-060 Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse FOLR1 Mouse Inquiry
TRIB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse EPCAM Mouse Inquiry
TRIB-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse EGFR Mouse Inquiry
TRIB-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse CD44 Mouse Inquiry
TRIB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse CD40 Mouse Inquiry
TRIB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse CD30 Mouse Inquiry
TRIB-054 Recombinant Anti-CD28 x Anti-CD3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse CD3 Mouse Inquiry
TRIB-050 Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD20 Mouse CD28 Mouse Inquiry
TRIB-040 Recombinant Anti-CD19 x Anti-CD28 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Mouse CD28 Mouse Inquiry
BSIG-063 Anti-CD28 x Anti-CSPG4 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse CSPG4 Mouse Inquiry
BSIG-062 Anti-CD28 x Anti-MUC1 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse MUC1 Mouse Inquiry
BSIG-061 Anti-CD28 x Anti-HN Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse HN Mouse Inquiry
BSIG-060 Anti-CD28 x Anti-FOLR1 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse FOLR1 Mouse Inquiry
BSIG-059 Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse EPCAM Mouse Inquiry
BSIG-058 Anti-CD28 x Anti-EGFR Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse EGFR Mouse Inquiry
BSIG-057 Anti-CD28 x Anti-CD44 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse CD44 Mouse Inquiry
BSIG-056 Anti-CD28 x Anti-CD40 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse CD40 Mouse Inquiry
BSIG-055 Anti-CD28 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse CD30 Mouse Inquiry
BSIG-054 Anti-CD28 x Anti-CD3 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse CD3 Mouse Inquiry
BSIG-050 Anti-CD20 x Anti-CD28 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD20 Mouse CD28 Mouse Inquiry
BSIG-040 Anti-CD19 x Anti-CD28 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Mouse CD28 Mouse Inquiry
CROSSAB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse CSPG4 Mouse Inquiry
CROSSAB-062 Recombinant Anti-CD28 x Anti-MUC1 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse MUC1 Mouse Inquiry
CROSSAB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse HN Mouse Inquiry
CROSSAB-060 Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse FOLR1 Mouse Inquiry
CROSSAB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse EPCAM Mouse Inquiry
CROSSAB-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse EGFR Mouse Inquiry
CROSSAB-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse CD44 Mouse Inquiry
CROSSAB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse CD40 Mouse Inquiry
CROSSAB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse CD30 Mouse Inquiry
CROSSAB-054 Recombinant Anti-CD28 x Anti-CD3 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse CD3 Mouse Inquiry
CROSSAB-050 Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (CrossMab) Human CrossMab CD20 Mouse CD28 Mouse Inquiry
CROSSAB-040 Recombinant Anti-CD19 x Anti-CD28 Bispecific Antibody (CrossMab) Human CrossMab CD19 Mouse CD28 Mouse Inquiry
IGFV-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse CSPG4 Mouse Inquiry
IGFV-062 Recombinant Anti-CD28 x Anti-MUC1 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse MUC1 Mouse Inquiry
IGFV-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse HN Mouse Inquiry
IGFV-060 Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse FOLR1 Mouse Inquiry
IGFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse EPCAM Mouse Inquiry
IGFV-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse EGFR Mouse Inquiry
IGFV-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse CD44 Mouse Inquiry
IGFV-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse CD40 Mouse Inquiry
IGFV-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse CD30 Mouse Inquiry
IGFV-054 Recombinant Anti-CD28 x Anti-CD3 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse CD3 Mouse Inquiry
IGFV-050 Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD20 Mouse CD28 Mouse Inquiry
IGFV-040 Recombinant Anti-CD19 x Anti-CD28 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Mouse CD28 Mouse Inquiry
BSDB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse CSPG4 Mouse Inquiry
BSDB-062 Recombinant Anti-CD28 x Anti-MUC1 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse MUC1 Mouse Inquiry
BSDB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Diabody) Human Diabody CD28 Mouse HN Mouse Inquiry
BSDB-060 Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse FOLR1 Mouse Inquiry
BSDB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD28 Mouse EPCAM Mouse Inquiry
BSDB-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (Diabody) Human Diabody CD28 Mouse EGFR Mouse Inquiry
BSDB-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse CD44 Mouse Inquiry
BSDB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse CD40 Mouse Inquiry
BSDB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse CD30 Mouse Inquiry
BSDB-054 Recombinant Anti-CD28 x Anti-CD3 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse CD3 Mouse Inquiry
BSDB-050 Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Diabody) Human Diabody CD20 Mouse CD28 Mouse Inquiry
BSDB-040 Recombinant Anti-CD19 x Anti-CD28 Bispecific Antibody (Diabody) Human Diabody CD19 Mouse CD28 Mouse Inquiry
BSFAB-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse CSPG4 Mouse Inquiry
BSFAB-062 Recombinant Anti-CD28 x Anti-MUC1 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse MUC1 Mouse Inquiry
BSFAB-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse HN Mouse Inquiry
BSFAB-060 Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse FOLR1 Mouse Inquiry
BSFAB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse EPCAM Mouse Inquiry
BSFAB-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse EGFR Mouse Inquiry
BSFAB-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse CD44 Mouse Inquiry
BSFAB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse CD40 Mouse Inquiry
BSFAB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse CD30 Mouse Inquiry
BSFAB-054 Recombinant Anti-CD28 x Anti-CD3 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse CD3 Mouse Inquiry
BSFAB-050 Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD20 Mouse CD28 Mouse Inquiry
BSFAB-040 Recombinant Anti-CD19 x Anti-CD28 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Mouse CD28 Mouse Inquiry
BSFV-063 Recombinant Anti-CD28 x Anti-CSPG4 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse CSPG4 Mouse Inquiry
BSFV-062 Recombinant Anti-CD28 x Anti-MUC1 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse MUC1 Mouse Inquiry
BSFV-061 Recombinant Anti-CD28 x Anti-HN Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse HN Mouse Inquiry
BSFV-060 Recombinant Anti-CD28 x Anti-FOLR1 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse FOLR1 Mouse Inquiry
BSFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse EPCAM Mouse Inquiry
BSFV-058 Recombinant Anti-CD28 x Anti-EGFR Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse EGFR Mouse Inquiry
BSFV-057 Recombinant Anti-CD28 x Anti-CD44 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse CD44 Mouse Inquiry
BSFV-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse CD40 Mouse Inquiry
BSFV-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse CD30 Mouse Inquiry
BSFV-054 Recombinant Anti-CD28 x Anti-CD3 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse CD3 Mouse Inquiry
BSFV-050 Recombinant Anti-CD20 x Anti-CD28 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD20 Mouse CD28 Mouse Inquiry
BSFV-040 Recombinant Anti-CD19 x Anti-CD28 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Mouse CD28 Mouse Inquiry

Background

MRP1, an ATP-binding cassette transporter, extrudes chemotherapeutics via glutathione-conjugated substrates, contributing to multidrug resistance (MDR) in cancers like leukemia and pancreatic carcinoma, where elevated MRP1 correlates with poor prognosis and chemoresistance. CD28, a T-cell co-stimulatory receptor, enhances antitumor immunity by amplifying TCR-mediated activation. Dual-targeting bispecific antibodies (BsAbs) against MRP1 and CD28 synergize with chemosensitization and immunomodulation. By blocking MRP1-mediated drug efflux, these BsAbs restore intracellular drug accumulation, while CD28 engagement activates cytotoxic T-cells to target resistant tumor cells. This strategy is transformative for hematological malignancies and solid tumors with MDR phenotypes, particularly in relapsed/refractory settings. Such BsAbs exemplify precision therapeutics bridging chemotherapy efficacy and immune checkpoint modulation.

Structure of MRP1 and CD28. (OA Literature)Fig.1 Schematic of MRP1 and CD28 structure.1,2

References

  1. Conseil, Gwenaëlle, and Susan P C Cole. "The First Cytoplasmic Loop in the Core Structure of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Contains Multiple Amino Acids Essential for Its Expression." International Journal of Molecular Sciences vol. 22,18 9710. 8 Sep. 2021, doi:10.3390/ijms22189710. Distributed under Open Access license CC BY 4.0, without modification.
  2. Chandler, Nicholas J et al. "T Cell Activation Machinery: Form and Function in Natural and Engineered Immune Receptors." International Journal of Molecular Sciences vol. 21,19 7424. 8 Oct. 2020, doi:10.3390/ijms21197424. Distributed under Open Access license CC BY 4.0. The image was modified by extracting and using only part of the original image.
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