MRP1 Bispecific Antibodies - Creative Biolabs

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Product List

CAT#	Product Name	Species Reactivity	BsAb Type	Target 1	Host Animal 1	Target 2	Host Animal 2	INQUIRY
KN-0825-JL7	Anti-MRP1 x Anti-CD28 Bispecific aptamer (RNA/RNA)	Human	Bispecific Aptamer	MRP1		CD28		Inquiry

Background

Multidrug resistance protein 1 (MRP1/ABCC1) is an ATP-binding cassette transporter that mediates the efflux of glutathione-conjugated xenobiotics, chemotherapeutic agents, and endogenous metabolites, contributing to multidrug resistance in cancer therapy. Its mechanism involves ATP hydrolysis to drive substrate translocation across cellular membranes, regulating detoxification pathways and cellular redox balance. MRP1 is extensively studied in oncology for its role in reducing chemotherapeutic efficacy, as well as in neurology and toxicology for modulating neurotoxicant accumulation and oxidative stress responses. Additionally, MRP1 is a critical target for developing inhibitors to overcome drug resistance and enhance therapeutic outcomes.

Schematic diagram of the secondary structure of human MRP1 highlighting CL4. (OA Literature) Fig.1 Schematic of the secondary structure of human MRP1.¹

Reference

Conseil, Gwenaëlle, and Susan P C Cole. "The First Cytoplasmic Loop in the Core Structure of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Contains Multiple Amino Acids Essential for Its Expression." International Journal of Molecular Sciences vol. 22,18 9710. 8 Sep. 2021, doi:10.3390/ijms22189710. Distributed under Open Access license CC BY 4.0, without modification.

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