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MSLN & CD47 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
KN-1022-LN2 Recombinant Anti-MSLN x Anti-CD47 Bispecific Antibody (Common heavy chain) (BsIgG) Human BsIgG MSLN CD47 Inquiry
BABFV-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins CD20 CD47 Inquiry
BABFV-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins CD19 CD47 Inquiry
BABFV-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins CD20 CD47 Inquiry
BABFV-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins CD19 CD47 Inquiry
FABVC-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins CD20 CD47 Inquiry
FABVC-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins CD19 CD47 Inquiry
FABVC-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins CD20 CD47 Inquiry
FABVC-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins CD19 CD47 Inquiry
SCDBC-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments CD20 CD47 Inquiry
SCDBC-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments CD19 CD47 Inquiry
SCDBC-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments CD20 CD47 Inquiry
SCDBC-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments CD19 CD47 Inquiry
BSDBC-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments CD20 CD47 Inquiry
BSDBC-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments CD19 CD47 Inquiry
BSDBC-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments CD20 CD47 Inquiry
BSDBC-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments CD19 CD47 Inquiry
SCDBF-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments CD20 CD47 Inquiry
SCDBF-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments CD19 CD47 Inquiry
SCDBF-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments CD20 CD47 Inquiry
SCDBF-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments CD19 CD47 Inquiry
BSFVF-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments CD20 CD47 Inquiry
BSFVF-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments CD19 CD47 Inquiry
BSFVF-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments CD20 CD47 Inquiry
BSFVF-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments CD19 CD47 Inquiry
BSDBF-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments CD20 CD47 Inquiry
BSDBF-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments CD19 CD47 Inquiry
BSDBF-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments CD20 CD47 Inquiry
BSDBF-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments CD19 CD47 Inquiry
BSTF-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CD20 CD47 Inquiry
BSTF-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CD19 CD47 Inquiry
BSTF-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CD20 CD47 Inquiry
BSTF-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CD19 CD47 Inquiry
BSCFV-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD20 CD47 Inquiry
BSCFV-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD19 CD47 Inquiry
BSCFV-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD20 CD47 Inquiry
BSCFV-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD19 CD47 Inquiry
MNAB-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD20 CD47 Inquiry
MNAB-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD19 CD47 Inquiry
MNAB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD20 CD47 Inquiry
MNAB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD19 CD47 Inquiry
BSFC-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD20 CD47 Inquiry
BSFC-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD19 CD47 Inquiry
BSFC-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD20 CD47 Inquiry
BSFC-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD19 CD47 Inquiry
BSCC-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD20 CD47 Inquiry
BSCC-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD19 CD47 Inquiry
BSCC-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD20 CD47 Inquiry
BSCC-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD19 CD47 Inquiry
BIBD-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Bibody) Human Bibody CD20 CD47 Inquiry
BIBD-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Bibody) Human Bibody CD19 CD47 Inquiry
BIBD-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Bibody) Human Bibody CD20 CD47 Inquiry
BIBD-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Bibody) Human Bibody CD19 CD47 Inquiry
FABFV-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD20 CD47 Inquiry
FABFV-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 CD47 Inquiry
FABFV-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD20 CD47 Inquiry
FABFV-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 CD47 Inquiry
MiniB-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Minibody) Human Minibody CD20 CD47 Inquiry
MiniB-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Minibody) Human Minibody CD19 CD47 Inquiry
MiniB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Minibody) Human Minibody CD20 CD47 Inquiry
MiniB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Minibody) Human Minibody CD19 CD47 Inquiry
SCTB-H125 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD20 CD47 Inquiry
SCTB-H117 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 CD47 Inquiry
SCDB-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD20 CD47 Inquiry
SCDB-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 CD47 Inquiry
FABIG-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD20 CD47 Inquiry
FABIG-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 CD47 Inquiry
TRIB-H229 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Triple Body) Human Triple Body CD20 CD47 Inquiry
TRIB-H219 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Triple Body) Human Triple Body CD19 CD47 Inquiry
BSIG-H227 Human Anti-CD20 x Anti-CD47 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD20 CD47 Inquiry
BSIG-H217 Human Anti-CD19 x Anti-CD47 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 CD47 Inquiry
CROSSAB-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (CrossMab) Human CrossMab CD20 CD47 Inquiry
CROSSAB-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (CrossMab) Human CrossMab CD19 CD47 Inquiry
IGFV-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD20 CD47 Inquiry
IGFV-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 CD47 Inquiry
BSDB-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Diabody) Human Diabody CD20 CD47 Inquiry
BSDB-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Diabody) Human Diabody CD19 CD47 Inquiry
BSFAB-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD20 CD47 Inquiry
BSFAB-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 CD47 Inquiry
BSFV-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD20 CD47 Inquiry
BSFV-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 CD47 Inquiry
SCTB-026 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD20 CD47 Inquiry
SCTB-017 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 CD47 Inquiry
SCDB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD20 CD47 Inquiry
SCDB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 CD47 Inquiry
FABIG-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD20 CD47 Inquiry
FABIG-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 CD47 Inquiry
TRIB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Triple Body) Human Triple Body CD20 CD47 Inquiry
TRIB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Triple Body) Human Triple Body CD19 CD47 Inquiry
BSIG-052 Anti-CD20 x Anti-CD47 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD20 CD47 Inquiry
BSIG-042 Anti-CD19 x Anti-CD47 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 CD47 Inquiry
CROSSAB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (CrossMab) Human CrossMab CD20 CD47 Inquiry
CROSSAB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (CrossMab) Human CrossMab CD19 CD47 Inquiry
IGFV-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD20 CD47 Inquiry
IGFV-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 CD47 Inquiry
BSDB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Diabody) Human Diabody CD20 CD47 Inquiry
BSDB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Diabody) Human Diabody CD19 CD47 Inquiry
BSFAB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD20 CD47 Inquiry
BSFAB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 CD47 Inquiry
BSFV-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD20 CD47 Inquiry
BSFV-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 CD47 Inquiry

Background

MSLN, also know as mesothelin, is a GPI-anchored membrane glycoprotein. It is proposed that MSLN may be involved in cell adhesion. MSLN is expressed on mesothelial cells, and overexpressed in various human tumor cells, including mesothelioma, ovarian cancer, cholangiocarcinoma, lung adenocarcinoma, and pancreatic adenocarcinoma. Given this, MSLN is a potential target for cancer therapy. CD47 molecule, also referred to IAP (Integrin associated protein), OA3 or MER6, is a 35 kDa transmembrane glycoprotein of 323 amino acids and belongs to the immunoglobulin (Ig) superfamily. In humans, this ubiquitously expressed cell surface protein is encoded by the gene mapping at the chromosome 3q13.12. CD47 plays a pivotal role in self-recognition and regulates the innate immunity by acting as an inhibitory signal for phagocytosis through macrophages, neutrophils, and dendritic cells. One critical mechanism under CD47-mediated immune evasion is that it can interact with SIRPα (Signal regulatory protein-alpha) expressed on myeloid cells, ultimately delivering an anti-phagocytic signal. Various solid and hematologic carcinomas exploit CD47 expression so as to escape immunological eradication. And its overexpression is clinically associated with poor prognoses.
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