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MSLN & CD47 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-1022-LN2 Recombinant Anti-MSLN x Anti-CD47 Bispecific Antibody (Common heavy chain) (BsIgG) Human BsIgG MSLN Human CD47 Human Inquiry
BABFV-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD20 Human CD47 Human Inquiry
BABFV-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD19 Human CD47 Human Inquiry
BABFV-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD20 Mouse CD47 Mouse Inquiry
BABFV-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD19 Mouse CD47 Mouse Inquiry
FABVC-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD20 Human CD47 Human Inquiry
FABVC-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD19 Human CD47 Human Inquiry
FABVC-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD20 Mouse CD47 Mouse Inquiry
FABVC-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD19 Mouse CD47 Mouse Inquiry
SCDBC-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD20 Human CD47 Human Inquiry
SCDBC-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD19 Human CD47 Human Inquiry
SCDBC-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD20 Mouse CD47 Mouse Inquiry
SCDBC-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD19 Mouse CD47 Mouse Inquiry
BSDBC-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD20 Human CD47 Human Inquiry
BSDBC-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD19 Human CD47 Human Inquiry
BSDBC-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD20 Mouse CD47 Mouse Inquiry
BSDBC-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD19 Mouse CD47 Mouse Inquiry
SCDBF-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD20 Human CD47 Human Inquiry
SCDBF-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD19 Human CD47 Human Inquiry
SCDBF-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD20 Mouse CD47 Mouse Inquiry
SCDBF-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD19 Mouse CD47 Mouse Inquiry
BSFVF-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD20 Human CD47 Human Inquiry
BSFVF-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD19 Human CD47 Human Inquiry
BSFVF-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD20 Mouse CD47 Mouse Inquiry
BSFVF-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD19 Mouse CD47 Mouse Inquiry
BSDBF-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD20 Human CD47 Human Inquiry
BSDBF-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD19 Human CD47 Human Inquiry
BSDBF-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD20 Mouse CD47 Mouse Inquiry
BSDBF-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD19 Mouse CD47 Mouse Inquiry
BSTF-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD20 Mouse CD47 Mouse Inquiry
BSTF-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD19 Mouse CD47 Mouse Inquiry
BSTF-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD20 Mouse CD47 Mouse Inquiry
BSTF-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD19 Mouse CD47 Mouse Inquiry
BSCFV-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD20 Mouse CD47 Mouse Inquiry
BSCFV-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD19 Mouse CD47 Mouse Inquiry
BSCFV-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD20 Mouse CD47 Mouse Inquiry
BSCFV-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD19 Mouse CD47 Mouse Inquiry
MNAB-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Miniantibody) Human Miniantibody CD20 Mouse CD47 Mouse Inquiry
MNAB-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Miniantibody) Human Miniantibody CD19 Mouse CD47 Mouse Inquiry
MNAB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Miniantibody) Human Miniantibody CD20 Mouse CD47 Mouse Inquiry
MNAB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Miniantibody) Human Miniantibody CD19 Mouse CD47 Mouse Inquiry
BSFC-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD20 Mouse CD47 Mouse Inquiry
BSFC-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD19 Mouse CD47 Mouse Inquiry
BSFC-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD20 Mouse CD47 Mouse Inquiry
BSFC-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD19 Mouse CD47 Mouse Inquiry
BSCC-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD20 Mouse CD47 Mouse Inquiry
BSCC-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD19 Mouse CD47 Mouse Inquiry
BSCC-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD20 Mouse CD47 Mouse Inquiry
BSCC-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD19 Mouse CD47 Mouse Inquiry
BIBD-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Bibody) Human Bibody CD20 Mouse CD47 Mouse Inquiry
BIBD-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Bibody) Human Bibody CD19 Mouse CD47 Mouse Inquiry
BIBD-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Bibody) Human Bibody CD20 Mouse CD47 Mouse Inquiry
BIBD-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Bibody) Human Bibody CD19 Mouse CD47 Mouse Inquiry
FABFV-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD20 Human CD47 Human Inquiry
FABFV-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 Human CD47 Human Inquiry
FABFV-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD20 Mouse CD47 Mouse Inquiry
FABFV-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 Mouse CD47 Mouse Inquiry
MiniB-H229 Recombinant Human Anti-CD20 x Human Anti-CD47 Bispecific Antibody (Minibody) Human Minibody CD20 Human CD47 Human Inquiry
MiniB-H219 Recombinant Human Anti-CD19 x Human Anti-CD47 Bispecific Antibody (Minibody) Human Minibody CD19 Human CD47 Human Inquiry
MiniB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Minibody) Human Minibody CD20 Mouse CD47 Mouse Inquiry
MiniB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Minibody) Human Minibody CD19 Mouse CD47 Mouse Inquiry
SCTB-H125 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD20 Human CD47 Human Inquiry
SCTB-H117 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 Human CD47 Human Inquiry
SCDB-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD20 Human CD47 Human Inquiry
SCDB-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Human CD47 Human Inquiry
FABIG-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD20 Human CD47 Human Inquiry
FABIG-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Human CD47 Human Inquiry
TRIB-H229 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD20 Human CD47 Human Inquiry
TRIB-H219 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Human CD47 Human Inquiry
BSIG-H227 Human Anti-CD20 x Anti-CD47 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD20 Human CD47 Human Inquiry
BSIG-H217 Human Anti-CD19 x Anti-CD47 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Human CD47 Human Inquiry
CROSSAB-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (CrossMab) Human CrossMab CD20 Human CD47 Human Inquiry
CROSSAB-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (CrossMab) Human CrossMab CD19 Human CD47 Human Inquiry
IGFV-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD20 Human CD47 Human Inquiry
IGFV-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Human CD47 Human Inquiry
BSDB-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Diabody) Human Diabody CD20 Human CD47 Human Inquiry
BSDB-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Diabody) Human Diabody CD19 Human CD47 Human Inquiry
BSFAB-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD20 Human CD47 Human Inquiry
BSFAB-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Human CD47 Human Inquiry
BSFV-H227 Recombinant Human Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD20 Human CD47 Human Inquiry
BSFV-H217 Recombinant Human Anti-CD19 x Anti-CD47 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Human CD47 Human Inquiry
SCTB-026 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD20 Mouse CD47 Mouse Inquiry
SCTB-017 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 Mouse CD47 Mouse Inquiry
SCDB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD20 Mouse CD47 Mouse Inquiry
SCDB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Mouse CD47 Mouse Inquiry
FABIG-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD20 Mouse CD47 Mouse Inquiry
FABIG-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Mouse CD47 Mouse Inquiry
TRIB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD20 Mouse CD47 Mouse Inquiry
TRIB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Mouse CD47 Mouse Inquiry
BSIG-052 Anti-CD20 x Anti-CD47 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD20 Mouse CD47 Mouse Inquiry
BSIG-042 Anti-CD19 x Anti-CD47 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Mouse CD47 Mouse Inquiry
CROSSAB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (CrossMab) Human CrossMab CD20 Mouse CD47 Mouse Inquiry
CROSSAB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (CrossMab) Human CrossMab CD19 Mouse CD47 Mouse Inquiry
IGFV-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD20 Mouse CD47 Mouse Inquiry
IGFV-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Mouse CD47 Mouse Inquiry
BSDB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Diabody) Human Diabody CD20 Mouse CD47 Mouse Inquiry
BSDB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Diabody) Human Diabody CD19 Mouse CD47 Mouse Inquiry
BSFAB-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD20 Mouse CD47 Mouse Inquiry
BSFAB-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Mouse CD47 Mouse Inquiry
BSFV-052 Recombinant Anti-CD20 x Anti-CD47 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD20 Mouse CD47 Mouse Inquiry
BSFV-042 Recombinant Anti-CD19 x Anti-CD47 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Mouse CD47 Mouse Inquiry

Background

MSLN (Mesothelin) is a glycosylphosphatidylinositol-anchored cell surface glycoprotein that is overexpressed in various cancers, including mesothelioma, ovarian cancer, and pancreatic cancer. CD47, on the other hand, is a protein found on the surface of normal cells that acts as a 'don't eat me' signal, preventing phagocytosis by immune cells. Anti-MSLN×anti-CD47 bispecific antibody (BsAb) is a novel therapeutic agent that involves binding to both MSLN and CD47 simultaneously. This binding blocks the inhibitory signal of the CD47/SIRPα axis, allowing immune cells such as macrophages to recognize and engulf cancer cells expressing MSLN. This promotes cancer cell death and boosts the immune response to tumors. The application fields of this BsAb include solid tumors like ovarian cancer and pancreatic cancer. Clinical trials are ongoing to evaluate its efficacy and safety, offering promising prospects for cancer treatment.

Fig.1 MSLN and CD47 structures. (Zhang, et al., 2015; https://commons.wikimedia.org/wiki/File:Protein_CD47_PDB_2JJS.png) Fig.1 Structures of MSLN and CD47.1,2

References

  1. Zhang, Yi-Fan, et al. "New high affinity monoclonal antibodies recognize non-overlapping epitopes on mesothelin for monitoring and treating mesothelioma." Scientific reports 5.1 (2015): 9928.
  2. From Wikipedia: By Pleiotrope - Own work, Public Domain, https://commons.wikimedia.org/wiki/File:Protein_CD47_PDB_2JJS.png
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