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NkG2A & BCMA Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0725-N89 Recombinant Human Anti-NkG2A x Mouse Anti-BCMA Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2A Human BCMA Mouse Inquiry
KN-0725-N53 Recombinant Human Anti-NkG2A x Mouse Anti-BCMA Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2A Human BCMA Mouse Inquiry
KN-0725-N15 Recombinant Human Anti-NkG2A x Mouse Anti-BCMA Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2A Human BCMA Mouse Inquiry
BSTF-H200 Recombinant Human Anti-BCMA x Human Anti-CD3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv BCMA Mouse CD3 Mouse Inquiry
BSTF-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv BCMA Mouse TACI Mouse Inquiry
BSTF-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv BCMA Mouse CD3 Mouse Inquiry
BSCFV-H201 Recombinant Human Anti-BCMA x Human Anti-TACI Bispecific Antibody (scFv-Fc) Human scFv-Fc BCMA Mouse TACI Mouse Inquiry
BSCFV-H200 Recombinant Human Anti-BCMA x Human Anti-CD3 Bispecific Antibody (scFv-Fc) Human scFv-Fc BCMA Mouse CD3 Mouse Inquiry
BSCFV-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (scFv-Fc) Human scFv-Fc BCMA Mouse TACI Mouse Inquiry
BSCFV-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (scFv-Fc) Human scFv-Fc BCMA Mouse CD3 Mouse Inquiry
MNAB-H201 Recombinant Human Anti-BCMA x Human Anti-TACI Bispecific Antibody (Miniantibody) Human Miniantibody BCMA Mouse TACI Mouse Inquiry
MNAB-H200 Recombinant Human Anti-BCMA x Human Anti-CD3 Bispecific Antibody (Miniantibody) Human Miniantibody BCMA Mouse CD3 Mouse Inquiry
MNAB-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Miniantibody) Human Miniantibody BCMA Mouse TACI Mouse Inquiry
MNAB-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (Miniantibody) Human Miniantibody BCMA Mouse CD3 Mouse Inquiry
BSFC-H201 Recombinant Human Anti-BCMA x Human Anti-TACI Bispecific Antibody (scFv-CH3) Human scFv-CH3 BCMA Mouse TACI Mouse Inquiry
BSFC-H200 Recombinant Human Anti-BCMA x Human Anti-CD3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 BCMA Mouse CD3 Mouse Inquiry
BSFC-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (scFv-CH3) Human scFv-CH3 BCMA Mouse TACI Mouse Inquiry
BSFC-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (scFv-CH3) Human scFv-CH3 BCMA Mouse CD3 Mouse Inquiry
BSCC-H201 Recombinant Human Anti-BCMA x Human Anti-TACI Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL BCMA Mouse TACI Mouse Inquiry
BSCC-H200 Recombinant Human Anti-BCMA x Human Anti-CD3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL BCMA Mouse CD3 Mouse Inquiry
BSCC-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL BCMA Mouse TACI Mouse Inquiry
BSCC-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL BCMA Mouse CD3 Mouse Inquiry
BIBD-H201 Recombinant Human Anti-BCMA x Human Anti-TACI Bispecific Antibody (Bibody) Human Bibody BCMA Mouse TACI Mouse Inquiry
BIBD-H200 Recombinant Human Anti-BCMA x Human Anti-CD3 Bispecific Antibody (Bibody) Human Bibody BCMA Mouse CD3 Mouse Inquiry
BIBD-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Bibody) Human Bibody BCMA Mouse TACI Mouse Inquiry
BIBD-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (Bibody) Human Bibody BCMA Mouse CD3 Mouse Inquiry
FABFV-H201 Recombinant Human Anti-BCMA x Human Anti-TACI Bispecific Antibody (Fab-Fv) Human Fab-Fv BCMA Human TACI Human Inquiry
FABFV-H200 Recombinant Human Anti-BCMA x Human Anti-CD3 Bispecific Antibody (Fab-Fv) Human Fab-Fv BCMA Human CD3 Human Inquiry
FABFV-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Fab-Fv) Human Fab-Fv BCMA Mouse TACI Mouse Inquiry
FABFV-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (Fab-Fv) Human Fab-Fv BCMA Mouse CD3 Mouse Inquiry
MiniB-H201 Recombinant Human Anti-BCMA x Human Anti-TACI Bispecific Antibody (Minibody) Human Minibody BCMA Human TACI Human Inquiry
MiniB-H200 Recombinant Human Anti-BCMA x Human Anti-CD3 Bispecific Antibody (Minibody) Human Minibody BCMA Human CD3 Human Inquiry
MiniB-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Minibody) Human Minibody BCMA Mouse TACI Mouse Inquiry
MiniB-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (Minibody) Human Minibody BCMA Mouse CD3 Mouse Inquiry
BSFAB-SAR019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-SAR001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFAB-NGB019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-NGB001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFAB-MEL019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-MEL001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFAB-BGN019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-BGN001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFAB-ABR019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-ABR001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFAB-PAP019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-PAP001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFAB-SAP019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-SAP001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-SAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFAB-RTA019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-RTA001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-RTA immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFAB-GEL019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-GEL001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-Gel immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFAB-PE019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-PE001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-PE immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFAB-DT019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFAB-DT001 Recombinant Anti-BCMA x Anti-TACI Tandem Fab-DT immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFV-SAR019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFV-SAR001 Recombinant Anti-BCMA x Anti-TACI Tandem scFv-SAR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFV-NGB019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFV-NGB001 Recombinant Anti-BCMA x Anti-TACI Tandem scFv-NGB immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFV-MEL019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFV-MEL001 Recombinant Anti-BCMA x Anti-TACI Tandem scFv-MEL immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFV-BGN019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFV-BGN001 Recombinant Anti-BCMA x Anti-TACI Tandem scFv-BGN immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFV-ABR019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
BSFV-ABR001 Recombinant Anti-BCMA x Anti-TACI Tandem scFv-ABR immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Mouse TACI Mouse Inquiry
BSFV-PAP019 Recombinant Human Anti-BCMA x Human Anti-TACI Tandem scFv-PAP immunotoxin (Bispecific Immunotoxin) Human Bispecific Immunotoxin BCMA Human TACI Human Inquiry
SCDB-H199 Recombinant Human Anti-BCMA x Anti-TACI Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody BCMA Human TACI Human Inquiry
SCDB-H198 Recombinant Human Anti-BCMA x Anti-CD3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody BCMA Human CD3 Human Inquiry
FABIG-H199 Recombinant Human Anti-BCMA x Anti-TACI Bispecific Antibody (Fab-IgG) Human Fab-IgG BCMA Human TACI Human Inquiry
FABIG-H198 Recombinant Human Anti-BCMA x Anti-CD3 Bispecific Antibody (Fab-IgG) Human Fab-IgG BCMA Human CD3 Human Inquiry
TRIB-H201 Recombinant Human Anti-BCMA x Anti-TACI Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv BCMA Human TACI Human Inquiry
TRIB-H200 Recombinant Human Anti-BCMA x Anti-CD3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv BCMA Human CD3 Human Inquiry
BSIG-H199 Human Anti-BCMA x Anti-TACI Bispecific Antibody (IgG-IgG) Human IgG-IgG BCMA Human TACI Human Inquiry
BSIG-H198 Human Anti-BCMA x Anti-CD3 Bispecific Antibody (IgG-IgG) Human IgG-IgG BCMA Human CD3 Human Inquiry
CROSSAB-H199 Recombinant Human Anti-BCMA x Anti-TACI Bispecific Antibody (CrossMab) Human CrossMab BCMA Human TACI Human Inquiry
CROSSAB-H198 Recombinant Human Anti-BCMA x Anti-CD3 Bispecific Antibody (CrossMab) Human CrossMab BCMA Human CD3 Human Inquiry
IGFV-H199 Recombinant Human Anti-BCMA x Anti-TACI Bispecific Antibody (IgG-scFv) Human IgG-scFv BCMA Human TACI Human Inquiry
IGFV-H198 Recombinant Human Anti-BCMA x Anti-CD3 Bispecific Antibody (IgG-scFv) Human IgG-scFv BCMA Human CD3 Human Inquiry
BSDB-H199 Recombinant Human Anti-BCMA x Anti-TACI Bispecific Antibody (Diabody) Human Diabody BCMA Human TACI Human Inquiry
BSDB-H198 Recombinant Human Anti-BCMA x Anti-CD3 Bispecific Antibody (Diabody) Human Diabody BCMA Human CD3 Human Inquiry
BSFAB-H199 Recombinant Human Anti-BCMA x Anti-TACI Bispecific Antibody (Tandem Fab) Human Tandem Fab BCMA Human TACI Human Inquiry
BSFAB-H198 Recombinant Human Anti-BCMA x Anti-CD3 Bispecific Antibody (Tandem Fab) Human Tandem Fab BCMA Human CD3 Human Inquiry
BSFV-H199 Recombinant Human Anti-BCMA x Anti-TACI Bispecific Antibody (Tandem scFv) Human Tandem scFv BCMA Human TACI Human Inquiry
BSFV-H198 Recombinant Human Anti-BCMA x Anti-CD3 Bispecific Antibody (Tandem scFv) Human Tandem scFv BCMA Human CD3 Human Inquiry
SCDB-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody BCMA Mouse TACI Mouse Inquiry
SCDB-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody BCMA Mouse CD3 Mouse Inquiry
FABIG-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Fab-IgG) Human Fab-IgG BCMA Mouse TACI Mouse Inquiry
FABIG-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (Fab-IgG) Human Fab-IgG BCMA Mouse CD3 Mouse Inquiry
TRIB-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv BCMA Mouse TACI Mouse Inquiry
TRIB-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv BCMA Mouse CD3 Mouse Inquiry
BSIG-021 Anti-BCMA x Anti-TACI Bispecific Antibody (IgG-IgG) Human IgG-IgG BCMA Mouse TACI Mouse Inquiry
BSIG-020 Anti-BCMA x Anti-CD3 Bispecific Antibody (IgG-IgG) Human IgG-IgG BCMA Mouse CD3 Mouse Inquiry
CROSSAB-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (CrossMab) Human CrossMab BCMA Mouse TACI Mouse Inquiry
CROSSAB-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (CrossMab) Human CrossMab BCMA Mouse CD3 Mouse Inquiry
IGFV-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (IgG-scFv) Human IgG-scFv BCMA Mouse TACI Mouse Inquiry
IGFV-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (IgG-scFv) Human IgG-scFv BCMA Mouse CD3 Mouse Inquiry
BSDB-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Diabody) Human Diabody BCMA Mouse TACI Mouse Inquiry
BSDB-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (Diabody) Human Diabody BCMA Mouse CD3 Mouse Inquiry
BSFAB-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Tandem Fab) Human Tandem Fab BCMA Mouse TACI Mouse Inquiry
BSFAB-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (Tandem Fab) Human Tandem Fab BCMA Mouse CD3 Mouse Inquiry
BSFV-021 Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Tandem scFv) Human Tandem scFv BCMA Mouse TACI Mouse Inquiry
BSFV-020 Recombinant Anti-BCMA x Anti-CD3 Bispecific Antibody (Tandem scFv) Human Tandem scFv BCMA Mouse CD3 Mouse Inquiry

Background

Natural killer group 2A (NkG2A) is an inhibitory receptor in the NkG2 family, primarily expressed on NK cells and CD8+ T cells. It forms heterodimers with CD94 to recognize HLA-E, a non-classical MHC-I molecule overexpressed in tumors, thereby suppressing cytotoxic lymphocyte activity and enabling immune evasion. Blocking NkG2A restores NK/T-cell-mediated tumor clearance, positioning it as a promising immune checkpoint. B-cell maturation antigen (BCMA), a TNF receptor superfamily member, is expressed exclusively on plasma cells and their malignant counterparts, promoting proliferation and survival in multiple myeloma. Bispecific antibodies co-targeting NkG2A and BCMA concurrently disturb immunosuppressive signaling via NkG2A inhibition and redirect cytotoxic effector cells to BCMA+ malignancies. This dual mechanism enhances tumor-specific cytotoxicity while overcoming microenvironment-driven resistance, offering therapeutic potential in hematologic cancers and refractory solid tumors with co-expressed targets.

Signaling pathways of NkG2A and BCMA. (OA Literature)Fig.1 NkG2A and BCMA signaling pathway.1,2

References

  1. Cazzetta, Valentina et al. "NKG2A Immune Checkpoint in Vδ2 T Cells: Emerging Application in Cancer Immunotherapy." Cancers vol. 15,4 1264. 16 Feb. 2023, doi:10.3390/cancers15041264. Distributed under Open Access license CC BY 4.0. The image was modified by extracting and using only part of the original image.
  2. Yu, Bo et al. "BCMA-targeted immunotherapy for multiple myeloma." Journal of Hematology & Oncology vol. 13,1 125. 17 Sep. 2020, doi:10.1186/s13045-020-00962-7. Distributed under Open Access license CC BY 4.0, without modification.
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