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NkG2A & CD30 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
KN-0725-N87 Recombinant Human Anti-NkG2A x Mouse Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab NkG2A Human CD30 Mouse Inquiry
KN-0725-N51 Recombinant Human Anti-NkG2A x Mouse Anti-CD30 Bispecific Antibody (scFv-Fc) Human scFv-Fc NkG2A Human CD30 Mouse Inquiry
KN-0725-N13 Recombinant Human Anti-NkG2A x Mouse Anti-CD30 Bispecific Antibody (IgG(H)-scFv) Human IgG-scFv NkG2A Human CD30 Mouse Inquiry
BIBD-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Bibody) Human Bibody CD30 Mouse CD64 Mouse Inquiry
BIBD-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse CD30 Mouse Inquiry
BIBD-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Bibody) Human Bibody CD28 Mouse CD30 Mouse Inquiry
BIBD-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Bibody) Human Bibody CD16 Mouse CD30 Mouse Inquiry
FABFV-H286 Recombinant Human Anti-CD30 x Human Anti-CD64 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD30 Human CD64 Human Inquiry
FABFV-H241 Recombinant Human Anti-CD3 x Human Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human CD30 Human Inquiry
FABFV-H231 Recombinant Human Anti-CD28 x Human Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 Human CD30 Human Inquiry
FABFV-H211 Recombinant Human Anti-CD16 x Human Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD16 Human CD30 Human Inquiry
FABFV-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD30 Mouse CD64 Mouse Inquiry
FABFV-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse CD30 Mouse Inquiry
FABFV-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 Mouse CD30 Mouse Inquiry
FABFV-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD16 Mouse CD30 Mouse Inquiry
MiniB-H286 Recombinant Human Anti-CD30 x Human Anti-CD64 Bispecific Antibody (Minibody) Human Minibody CD30 Human CD64 Human Inquiry
MiniB-H241 Recombinant Human Anti-CD3 x Human Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD3 Human CD30 Human Inquiry
MiniB-H231 Recombinant Human Anti-CD28 x Human Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD28 Human CD30 Human Inquiry
MiniB-H211 Recombinant Human Anti-CD16 x Human Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD16 Human CD30 Human Inquiry
MiniB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Minibody) Human Minibody CD30 Mouse CD64 Mouse Inquiry
MiniB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse CD30 Mouse Inquiry
MiniB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD28 Mouse CD30 Mouse Inquiry
MiniB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Minibody) Human Minibody CD16 Mouse CD30 Mouse Inquiry
SCTB-H179 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD30 Human CD64 Human Inquiry
SCTB-H135 Recombinant Human Anti-CD30 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human CD30 Human Inquiry
SCTB-H126 Recombinant Human Anti-CD30 x Human Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Human CD30 Human Inquiry
SCTB-H111 Recombinant Human Anti-CD30 x Human Anti-CD16 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD16 Human CD30 Human Inquiry
SCDB-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD30 Human CD64 Human Inquiry
SCDB-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human CD30 Human Inquiry
SCDB-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Human CD30 Human Inquiry
SCDB-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD16 Human CD30 Human Inquiry
FABIG-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD30 Human CD64 Human Inquiry
FABIG-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human CD30 Human Inquiry
FABIG-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Human CD30 Human Inquiry
FABIG-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD16 Human CD30 Human Inquiry
TRIB-H286 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD30 Human CD64 Human Inquiry
TRIB-H241 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human CD30 Human Inquiry
TRIB-H231 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Human CD30 Human Inquiry
TRIB-H211 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD16 Human CD30 Human Inquiry
BSIG-H284 Human Anti-CD30 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD30 Human CD64 Human Inquiry
BSIG-H239 Human Anti-CD3 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human CD30 Human Inquiry
BSIG-H229 Human Anti-CD28 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Human CD30 Human Inquiry
BSIG-H209 Human Anti-CD16 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD16 Human CD30 Human Inquiry
CROSSAB-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD30 Human CD64 Human Inquiry
CROSSAB-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD3 Human CD30 Human Inquiry
CROSSAB-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD28 Human CD30 Human Inquiry
CROSSAB-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD16 Human CD30 Human Inquiry
IGFV-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD30 Human CD64 Human Inquiry
IGFV-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human CD30 Human Inquiry
IGFV-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Human CD30 Human Inquiry
IGFV-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD16 Human CD30 Human Inquiry
BSDB-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD30 Human CD64 Human Inquiry
BSDB-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD3 Human CD30 Human Inquiry
BSDB-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD28 Human CD30 Human Inquiry
BSDB-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD16 Human CD30 Human Inquiry
BSFAB-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD30 Human CD64 Human Inquiry
BSFAB-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human CD30 Human Inquiry
BSFAB-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Human CD30 Human Inquiry
BSFAB-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD16 Human CD30 Human Inquiry
BSFV-H284 Recombinant Human Anti-CD30 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD30 Human CD64 Human Inquiry
BSFV-H239 Recombinant Human Anti-CD3 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human CD30 Human Inquiry
BSFV-H229 Recombinant Human Anti-CD28 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Human CD30 Human Inquiry
BSFV-H209 Recombinant Human Anti-CD16 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD16 Human CD30 Human Inquiry
SCTB-083 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD30 Mouse CD64 Mouse Inquiry
SCTB-037 Recombinant Anti-CD30 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse CD30 Mouse Inquiry
SCTB-027 Recombinant Anti-CD30 x Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 Mouse CD30 Mouse Inquiry
SCTB-011 Recombinant Anti-CD30 x Anti-CD16 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD16 Mouse CD30 Mouse Inquiry
SCDB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD30 Mouse CD64 Mouse Inquiry
SCDB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse CD30 Mouse Inquiry
SCDB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 Mouse CD30 Mouse Inquiry
SCDB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD16 Mouse CD30 Mouse Inquiry
FABIG-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD30 Mouse CD64 Mouse Inquiry
FABIG-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse CD30 Mouse Inquiry
FABIG-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 Mouse CD30 Mouse Inquiry
FABIG-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD16 Mouse CD30 Mouse Inquiry
TRIB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD30 Mouse CD64 Mouse Inquiry
TRIB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse CD30 Mouse Inquiry
TRIB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD28 Mouse CD30 Mouse Inquiry
TRIB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD16 Mouse CD30 Mouse Inquiry
BSIG-110 Anti-CD30 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD30 Mouse CD64 Mouse Inquiry
BSIG-065 Anti-CD3 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse CD30 Mouse Inquiry
BSIG-055 Anti-CD28 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 Mouse CD30 Mouse Inquiry
BSIG-034 Anti-CD16 x Anti-CD30 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD16 Mouse CD30 Mouse Inquiry
CROSSAB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD30 Mouse CD64 Mouse Inquiry
CROSSAB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse CD30 Mouse Inquiry
CROSSAB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD28 Mouse CD30 Mouse Inquiry
CROSSAB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (CrossMab) Human CrossMab CD16 Mouse CD30 Mouse Inquiry
IGFV-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD30 Mouse CD64 Mouse Inquiry
IGFV-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse CD30 Mouse Inquiry
IGFV-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 Mouse CD30 Mouse Inquiry
IGFV-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD16 Mouse CD30 Mouse Inquiry
BSDB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD30 Mouse CD64 Mouse Inquiry
BSDB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD3 Mouse CD30 Mouse Inquiry
BSDB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD28 Mouse CD30 Mouse Inquiry
BSDB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Diabody) Human Diabody CD16 Mouse CD30 Mouse Inquiry
BSFAB-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD30 Mouse CD64 Mouse Inquiry
BSFAB-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse CD30 Mouse Inquiry
BSFAB-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 Mouse CD30 Mouse Inquiry
BSFAB-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD16 Mouse CD30 Mouse Inquiry
BSFV-110 Recombinant Anti-CD30 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD30 Mouse CD64 Mouse Inquiry
BSFV-065 Recombinant Anti-CD3 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse CD30 Mouse Inquiry
BSFV-055 Recombinant Anti-CD28 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 Mouse CD30 Mouse Inquiry
BSFV-034 Recombinant Anti-CD16 x Anti-CD30 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD16 Mouse CD30 Mouse Inquiry

Background

Natural killer group 2A (NkG2A) is an inhibitory receptor expressed on NK and cytotoxic T cells, suppressing immune activation by blocking HLA-E signaling pathways. Cluster of differentiation 30 (CD30), a TNF receptor superfamily member, is overexpressed in Hodgkin's lymphoma and select T-cell malignancies, functioning as a tumor-specific antigen and therapeutic vulnerability. Dual-targeting NkG2A/CD30 bispecific antibodies synergize immune activation and tumor-directed cytotoxicity. By blocking NkG2A-mediated immunosuppression while engaging CD30 on malignant cells, these molecules enhance NK/T-cell effector functions through redirected ADCC and direct apoptotic signaling. Their bifunctional design addresses resistance mechanisms in CD30-positive lymphomas, particularly relapsed/refractory Hodgkin's disease, by coupling checkpoint inhibition with tumor antigen-specific targeting. This dual mechanism broadens therapeutic potential across hematologic malignancies with unmet needs.

NKG2A/CD94 signalings in NK cells and T cells, and CD30/CD30L signaling via trogocytosis. (OA Literature)Fig.1 NKG2A/CD94 and CD30/CD30L signalings.1,2,3

References

  1. Wang, Xiaotong et al. "Implications of NKG2A in immunity and immune-mediated diseases." Frontiers in Immunology vol. 13 960852. 10 Aug. 2022, doi:10.3389/fimmu.2022.960852.
  2. Nakashima, Makoto, and Kaoru Uchimaru. "CD30 Expression and Its Functions during the Disease Progression of Adult T-Cell Leukemia/Lymphoma." International Journal of Molecular Sciences vol. 24,10 8731. 13 May. 2023, doi:10.3390/ijms24108731.
  3. Distributed under Open Access license CC BY 4.0. The image was modified by extracting and using only part of the original image.
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